A new polymorphism in the promotor of the Interleukin 5 receptor alpha subunit (IL-5RA) gene

Immunogenetics

Volumn 48, Issue 1, 1998, Pages 65-66

  Kollintza, A ^a   Worthington, J ^a   John, S ^a   Ollier, W E R ^a   Hajeer, A H ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

IL 5R ; Polymorphism; Promoter; RFLP

Indexed keywords

DNA; INTERLEUKIN 5 RECEPTOR; INTERLEUKIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; DELETION MUTANT; DNA POLYMORPHISM; GENE MAPPING; HUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR GENE; SINGLE STRAND CONFORMATION POLYMORPHISM; ALLELE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; MOLECULAR GENETICS;

ALLELES; GENE FREQUENCY; HUMANS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROMOTER REGIONS (GENETICS); RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-5;

EID: 0031596857     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510050402     Document Type: Article

References (10)

1. Bohjanen, P.R., Okajima, M., and Hodes, R.J. Differential regulation of interleukin 4 and interleukin 5 gene expression: a comparison of T-cell gene induction by anti-CD3 antibody or by exogenous lymphokines. Proc Natl Acad Sci USA 87: 5283-5287, 1990
2. Clutterbuck, E.J., Hirst, E.M., and Sanderson, C.J. Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GM-CSF. Blood 73: 1504-1512, 1989
3. Fujisawa, T., Abu-Ghazaleh, R., Kita, H., Sanderson, C.J., and Gleich, G.J. Regulatory effect of cytokines on eosinophil degranulation. J Immunol 144: 642-646, 1990
4. Isobe, M., Kumura, Y., Murata, Y., Takaki, S., Tominaga, A., Takatsu, K., and Ogita, Z. Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics 14: 755-758, 1992
5. Sun, Z., Yergeau, D.A., Tuypens, T., Tavernier, J., Paul, C.C., Baumann, M.A., Tenen, D.G., and Ackerman, S.J. Identification and characterisation of a functional promoter region in the IL-5 receptor alpha subunit gene. J Biol Chem 270: 1462-1471, 1995
6. Takaki, S., Kanazawa, H., Shiiba, M., and Takatsu, K. A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor α-chain and its function in IL-5-mediated growth signal transduction. Mol Cell Biol 14: 7404-7413, 1994
7. Tavernier, J., Devos, R., Cornelis, S., Tuypens, T., Van der Heyden, J., Fiers, W., and Plaetinck, G. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific chain and a chain shared with the receptor for GM-CSF. Cell 66: 1175-1184, 1991
8. Walsh, G.M., Hartnell, A., Wardlaw, A.J., Kurihara, K., Sanderson, C.J., and Kay, A.B. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. Immunology. 71: 258-265, 1990
9. Wang, J.M., Rambaldi, A., Biondi, A., Chen, Z.G., Sanderson, C.J., and Mantovani, A. Recombinant human interleukin 5 is a selective eosinophil chemoattractant. Eur J Immunol 19: 701-705, 1990
10. Yamaguchi, Y., Hayashi, Y., Sugama, Y. Miura, Y., Kasahara, T., Kitamura, S., Torisu, M., Mita, S., Tominaga, A., Takatsu, K., Suda, T. Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor. J Exp Med 167: 1737-1742, 1988