The M2 muscarinic receptor antagonist methoctramine activates mast cells via pertussis toxin-sensitive G proteins

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 357, Issue 4, 1998, Pages 357-362

  Chahdi, Ahmed ^a   Daeffler, Laurent ^a   Bueb, Jean Luc ^b   Gies, Jean Pierre ^a   Landry, Yves ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b Neuroimmunologie et Inflammation   (Luxembourg)

Author keywords

G proteins; Inositol phosphates generation; Mast cell secretion; Methoctramine; Muscarinic receptor antagonists; Receptor independent activation

Indexed keywords

BENZALKONIUM CHLORIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; HISTAMINE; INOSITOL PHOSPHATE; METHOCTRAMINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITIDE; BORDETELLA VIRULENCE FACTOR; DIAMINE; N ACETYLNEURAMINIC ACID; SIALIDASE;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; EXOCYTOSIS; HYDROLYSIS; MAST CELL; NONHUMAN; PERITONEUM MAST CELL; RAT; ANIMAL; COMPARATIVE STUDY; DRUG EFFECT; HISTAMINE RELEASE; MALE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; DIAMINES; GTP-BINDING PROTEINS; HISTAMINE RELEASE; INOSITOL PHOSPHATES; MALE; MAST CELLS; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; PERTUSSIS TOXIN; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; VIRULENCE FACTORS, BORDETELLA;

EID: 0031596855     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005179     Document Type: Article

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