The influence of the antidepressant pirlindole and its dehydro- derivative on the activity of monoamine oxidase A and GABA(A) receptor binding

Journal of Neural Transmission, Supplement

Volumn , Issue 52, 1998, Pages 337-342

  Medvedev, A E ^a,d   Shvedov, V I ^b   Chulkova, T M ^a   Fedotova, O A ^b   Saederup, E ^c   Squires, R F ^c  

^a INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^b Institute of Pharmaceutical Technology   (Russian Federation)

^c NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^d INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; DEHYDROPIRLINDOLE; MONOAMINE OXIDASE A INHIBITOR; PIRLINDOLE; UNCLASSIFIED DRUG; 3,3A DEHYDROPYRAZIDOL; 3,3A-DEHYDROPYRAZIDOL; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; 4' CHLORODIAZEPAM; 4'-CHLORODIAZEPAM; AMINE OXIDASE (FLAVIN CONTAINING); ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; CARBAZOLE DERIVATIVE; CARBOLINE DERIVATIVE; CLOZAPINE; ISOENZYME; METHYL 6,7-DIMETHOXY-4-ETHYL-BETA-CARBOLINE-3-CARBOXYLATE; MONOAMINE OXIDASE INHIBITOR;

ANIMAL TISSUE; ARTICLE; BRAIN; DRUG RECEPTOR BINDING; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; NONHUMAN; PLACENTA; PRIORITY JOURNAL; RAT; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FEMALE; KINETICS; LIVER MITOCHONDRION; METABOLISM; MITOCHONDRION; PREGNANCY;

ANIMALS; ANTIDEPRESSIVE AGENTS; BENZODIAZEPINONES; BRAIN; CARBAZOLES; CARBOLINES; CLOZAPINE; FEMALE; GABA ANTAGONISTS; HUMANS; ISOENZYMES; KINETICS; MITOCHONDRIA; MITOCHONDRIA, LIVER; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PLACENTA; PREGNANCY; RATS; RECEPTORS, GABA-A;

EID: 0031596708     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6499-0_36     Document Type: Article

References (19)

1. Anderson M, Tipton KF (1994) Estimation of monoamine oxidase concentration in soluble and membrane-bound preparations by inhibitor binding. J Neural Transm [Suppl] 41: 47-53
2. Anderson M, Waldmeier P, Tipton KF (1991) The inhibition of monoamine oxidase by brofaromine. Biochem Pharmacol 41: 1871-1877
3. Baumanis EA, Birska IA, Reikhman GO, Shvedov VI, Gorkin VZ (1987) On the mechanism of modification by pyrazidol of the catalytic activity of mitochondrial monoamine oxidase. Probl Med Chem N6: 90-96
4. Dvoryantseva GG, Pol'shakov VI, Sheikner YuN, Shvedov VI, Grynev AN, Mashkovsky MD, Karapetyan HA, Strukov YT (1985) Structure-activity relationship in pyrazino[3,2,1-j,k] carbazole derivatives. Eur J Med Chem-Chem Ther 230: 414-418
5. Gorkin VZ (1985) Studies on the nature and specific inhibition of monoamine oxidases. In: Kelemen K, Magyar K, Vizi ES (eds) Neuropharmacology-85. Akademiai Kiado, Budapest, pp 9-14
6. Keller HH, Kettler R, Keller G, Da Prada M (1987) Short-acting novel MAO inhibitors: In vitro evidence for the reversibility of MAO inhibition by moclobemide and Ro 1606491. Naunyn Schmiedebergs Arch Pharmacol 335: 12-20
7. Kuksgaus NE, Golovina SM, Adnreeva NI (1991) The influence of the Soviet antidepressants pyrazidol and incazan on the effect of clonidine. Farmacol Toksikol 54(1): 11-14
8. Luque JM, Erat R, Kettler R, Cesura A, Da Prada M, Richards JG (1994) Radioautographic evidence that the GABA A receptor antagonist SR 95531 is a substrate inhibitor of MAO A in the rat and human locus coerulens. Eur J Neurosci 6: 1038-1049
9. Martorana PA, Heucke O, Nitz R-E (1979) The new antidepressant pirlindole. Antagonism of acute overdose in the mouse. Arzneimittelforschung/Drug Res 29: 950-952
10. Mashkovsky MD (1993) Drugs: reference book for clinicians, vol 1. Meditzina, Moscow, pp 110-116
11. Mashkovsky MD, Gorkin VZ, Veryovkina IV, Asnina VV, Tupikina SM (1981) Selective inhibition of type A monoamine oxidase by pyrazidol. Buyl Eksper Biol Med N2: 169-171
12. Medvedev A, Gorkin V, Shvedov V, Fedotova O, Fedotova I, Semiokhina A (1992) Efficacy of pirlindole, a highly selective reversible inhibitor of monoamine oxidase type A, in the prevention of experimentally induced epileptic seizures. Drug Invest 4: 501-507
13. Medvedev AE, Kirkel AZ, Kamyhanskaya NS, Moskvitina TA, Axenova LN, Gorkin VZ, Andreeva NI, Golovina SM, Mashkovsky MD (1994) Monoamine oxidase inhibition by novel antidepressant tetrindole. Biochem Pharmacol 47: 303-308
14. Simon P, Poncelet M, Chermat R (1985) Persistence of central effects of pirindole, a short-acting monoamine oxidase inhibitor, in the presence of monoamine oxidase inhibitor. Drug Dev Res 5: 323-326
15. Singer TP (1985) Inhibitors of FAD-containing monoamine oxidases. In: Mondovi B (ed) Structure and funcitons of amine oxidases. CRC Press, Boca Raton, pp 219-229
16. 35S]TBPS binding. Brain Res 414: 357-364
17. 35-S-t-butylbiscyclophosphothionate binding sites in rat brain. Brain Res 441: 15-22
18. 35S]t-Butylbicyclophosphorothionate binds with high affinity to brain-specific coupled γ-aminobutyric acid-A and ion recognition sites. Mol Pharmacol 23: 326-336
19. Verstakova OL, Gerchikov LN, Chicherina LA, Sharova SA, Liberman SS (1985) Toxicological characteristics of the Soviet antidepressant pyrazidol. Farmacol Toksikol 48: 57-60