Modulation of 17α-hydroxylase/17,20-lyase activity of guinea pig cytochrome P450c17 by site-directed mutagenesis

DNA and Cell Biology

Volumn 17, Issue 8, 1998, Pages 707-715

  Beaudoin, Claude ^a   Lavallée, Bernard ^a   Tremblay, Yves ^a   Hum, Dean W ^a   Breton, Rock ^a   De Launoit, Yvan ^b   Bélanger, Alain ^a  

^a LAVAL UNIVERSITY   (Canada)

^b INSTITUT PASTEUR DE LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

17 HYDROXYPREGNENOLONE; CYTOCHROME P450 ISOENZYME; CYTOCHROME P450C17; HYDROXYPROGESTERONE; PRASTERONE; PREGNENOLONE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; UNCLASSIFIED DRUG; MULTIENZYME COMPLEX; RECOMBINANT PROTEIN; STEROID;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; SITE DIRECTED MUTAGENESIS; STEROIDOGENESIS; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; COMPARATIVE STUDY; GENETICS; GUINEA PIG; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; PROTEIN PROCESSING; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE;

ANIMALIA; ASTEROIDEA; BOVINAE; CAVIA PORCELLUS; SUIDAE; SUS SCROFA;

17-ALPHA-HYDROXYPREGNENOLONE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DEHYDROEPIANDROSTERONE; EVOLUTION, MOLECULAR; GUINEA PIGS; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; STEROID 17-ALPHA-HYDROXYLASE; STEROIDS; SUBSTRATE SPECIFICITY;

EID: 0031596424     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.1998.17.707     Document Type: Article

References (17)

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