Ca2+ signaling by cholinergic and α1-adrenergic agonists is up- regulated in lacrimal and submandibular glands in a murine model of Sjogren's syndrome

Clinical Immunology and Immunopathology

Volumn 89, Issue 2, 1998, Pages 134-140

  Zoukhri, Driss ^a   Hodges, Robin R ^a   Rawe, Ian M ^a   Dartt, Darlene A ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

Animal models; Exocrine tissue; Inflammation; Second messengers; Signal transduction

Indexed keywords

ACETYLCHOLINE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM CHANNEL; CALCIUM ION; CHOLINERGIC RECEPTOR STIMULATING AGENT; DIACYLGLYCEROL; FURA 2; INOSITOL TRISPHOSPHATE; INTERLEUKIN 1BETA; INTERLEUKIN 6; NORADRENALIN; PHOSPHOLIPASE C; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM;

ALPHA ADRENERGIC STIMULATION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC DENERVATION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHOLINERGIC STIMULATION; CONTROLLED STUDY; DRY EYE; HISTOPATHOLOGY; INFLAMMATION; LACRIMAL GLAND DISEASE; LACRIMATION; LYMPHOCYTIC INFILTRATION; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PARASYMPATHETIC INNERVATION; PRIORITY JOURNAL; SALIVARY GLAND DISEASE; SECOND MESSENGER; SENSORY NERVE; SIGNAL TRANSDUCTION; SJOEGREN SYNDROME; STIMULUS RESPONSE; SYMPATHETIC INNERVATION; XEROSTOMIA; ANIMAL; CHEMISTRY; CYTOLOGY; DACRYOCYSTITIS; DISEASE MODEL; DRUG EFFECT; LACRIMAL APPARATUS; LYMPHOCYTE; METABOLISM; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SUBMANDIBULAR GLAND; UPREGULATION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CALCIUM; CHOLINERGIC AGONISTS; DACRYOCYSTITIS; DISEASE MODELS, ANIMAL; LACRIMAL APPARATUS; LYMPHOCYTES; MICE; MICE, INBRED MRL LPR; SIGNAL TRANSDUCTION; SJOGREN'S SYNDROME; SUBMANDIBULAR GLAND; UP-REGULATION;

EID: 0031595736     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1998.4598     Document Type: Article

References (25)

1. Putney J. W. Phosphoinositides and alpha-1 adrenergic receptors. The Alpha-1 Adrenergic Receptor. 1987;Humana, Clifton. p. 189-208.
2. Putney J. W. A model for receptor-regulated calcium entry. Cell Calcium. 7:1986;1-12.
3. Fleming N., Bilan P. T., Sliwinski-Lis E., Carvalho V. Muscarinic, alpha 1-adrenergic and peptidergic agonists stimulate phosphoinositide hydrolysis and regulate mucin secretion in rat submandibular gland cells. Pflugers Arch. 409:1987;416-421.
4. Petersen O. H. Stimulus-secretion coupling: Cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells. J. Physiol. (London). 448:1992;1-51.
5. Dartt D. A., Dicker D. M., Ronco L. V., Kjeldsen I. M., Hodges R. R., Murphy S. A. Lacrimal gland inositol trisphosphate isomer and tetrakisphosphate production. Am. J. Physiol. (Gastrintest. Liver Physiol.). 259:1990;G274-G281.
6. Doughney C., Dormer R. L., McPherson M. A. Adrenergic regulation of formation of inositol phosphates in rat submandibular acini. Biochem. J. 241:1987;705-709.
7. 1. Am. J. Physiol. 262:1992;G1087-G1096.
8. Talal, N. Moutsopoulos, H. M. Kassan, S. S. Sjögren's Syndrome. Clinical and Immunological Aspects, Springer-Verlag, Berlin.
9. Fox R. I. Pathogenesis of Sjögren's syndrome. Rheum. Dis. Clin. North Am. 18:1992;517-538.
10. Holly F. J. Tear film physiology. Int. Ophthalmol. Clin. 27:1987;2-6.
11. Saito I., Terauchi K., Shimuta M., Nishiimura S., Yoshino K., Takeuchi T., Tsubota K., Miyasaka N. Expression of cell adhesion molecules in the salivary and lacrimal glands of Sjögren's syndrome. J. Clin. Lab Anal. 7:1993;180-187.
12. Sato E. H., Ariga H., Sullivan D. A. Impact of androgen therapy in Sjögren's syndrome: Hormonal influence on lymphocyte populations and Ia expression in lacrimal glands of MRL/Mp-lpr/lpr mice. Invest. Ophthalmol. Vis. Sci. 33:1992;2537-2545.
13. Andrews B. S., Eisenberg R. A., Theofilopoulos A. N., Izui S., Wilson C. B., McConahey P. J., Murphy E. D., Roths J. B., Dixon F. J. Spontaneous murine lupus-like syndromes: Clinical and immunopathological manifestations in several strains. J. Exp. Med. 149:1978;1198-1215.
14. Theofilopoulos A. N., Dixon F. J. Murine models of systemic lupus erythematosus. Adv. Immunol. 37:1985;269-390.
15. Yamamoto H., Sims N. E., Macauley S. P., Nguyen K. H., Nakagawa Y., Humphreys-Beher M. G. Alterations in the secretory response of non-obese diabetic (NOD) mice to muscarinic receptor stimulation. Clin. Immunol. Immunopathol. 78:1996;245-255.
16. Hurst S., Collins S. M. Interleukin-1β modulation of norepinephrine release from rat myenteric nerves. Am. J. Physiol. (Gastrointest. Liver Physiol.). 264:1993;G30-G35.
17. Main C., Blennerhassett P., Collins S. M. Human recombinant interleukin 1β suppresses acetylcholine release from rat myenteric plexus. Gastroenterology. 104:1993;1648-1654.
18. Fleming W. W., McPhillips J. J., Westfall D. P. Postjunctional supersensitivity of excitable tissues to drugs. Ergeb. Physiol. 68:1973;55-119.
19. Hasegawa N., Imaizumi Y., Wantanabe M. Parasympathetic denervation supersensitivity in the rat iris sphincter muscle: Anin vitro. Jpn. J. Pharmacol. 43:1987;143-151.
20. Maes J. P. The effect of the removal of the superior cervical ganglion on lachrymal secretion. Am. J. Physiol. 123:1938;359-363.
21. de Haas E. B. H. Lacrimal gland response to parasympathicomimetics after parasympathetic denervation. Arch. Ophthal. 64:1960;34-43.
22. Hoffman R. W., Alspaugh M. A., Waggie K. S., Durham B., Walker S. E. Sjögren's syndrome in MRL/l and MRL/n mice. Arthritis Rheum. 27:1984;157-165.
23. Verhagen C., Rowshani T., Willekens B., Van Haeringen N. J. Spontaneous development of corneal crystaline deposits in MRL/Mp mice. Invest. Ophthalmol. Vis. Sci. 36:1995;454-461.
24. Jabs D. A., Alexander E. L., Green W. R. Ocular inflammation in autoimmune MRL/Mp mice. Invest. Ophthalmol. Vis. Sci. 26:1985;1223-1229.
25. Jabs D. A., Prendergast R. A. Ocular inflammation in MRL/Mp-lpr/lpr mice. Invest. Ophthalmol. Vis. Sci. 32:1991;1944-1947.