Apneic threshold for CO2 in the anesthetized rat: Fundamental properties under steady-state conditions

Journal of Applied Physiology

Volumn 85, Issue 3, 1998, Pages 898-907

  Boden, A G ^a   Harris, M C ^a   Parkes, M J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Breathing; Carbon dioxide; Hypocapnia

Indexed keywords

CARBON DIOXIDE; OXYGEN;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; APNEA; ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DIAPHRAGM MUSCLE; ELECTROMYOGRAM; HYPERVENTILATION; LUNG INFLATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE; VAGOTOMY; ANESTHESIA; ANIMAL; BLOOD; BREATHING MECHANICS; ELECTROMYOGRAPHY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANESTHESIA; ANIMALS; APNEA; CARBON DIOXIDE; ELECTROMYOGRAPHY; MALE; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY MECHANICS; VAGOTOMY;

EID: 0031595534     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.85.3.898     Document Type: Article

References (39)

1. Altose, M. D., R. J. Castele, A. F. Connors, and A. F. Dimarco. Effects of volume and frequency of mechanical ventilation on respiratory activity in humans. Respir. Physiol. 66: 171-180, 1986.
2. Bainton, C. R., and R. A. Mitchell. Posthyperventilation apnea in awake man. J. Appl. Physiol. 21: 411-415, 1966.
3. 2 and results of vagal cooling. Respir. Physiol. 34: 121-134, 1978.
4. Bellville, J. W., B. J. Whipp, R. D. Kaufman, G. D. Swanson, K. A. Aqleh, and D. M. Wiberg. Central and peripheral chemoreflex loop gain in normal and carotid body-resected subjects. J. Appl. Physiol. 46: 843-853, 1979.
5. 2 in the urethane anaesthetised rat (Abstract). J. Physiol. (Lond.) 493: 33-P, 1996.
6. Cilley, R. E., J. Y. Wang, and A. G. Coran. Lung injury produced by moderate lung overinflation in rats. J. Pediatr. Surg. 28: 488-493, 1993.
7. Cragg, P. A., and D. B. Drysdale. Interaction of hypoxia and hypercapnia on ventilation, tidal volume and respiratory frequency in the anaesthetized rat. J. Physiol. (Lond.) 341: 477-493, 1983.
8. Datta, A. K., S. A. Shea, R. L. Horner, and A. Guz. The influence of induced hypocapnia and sleep on the endogenous respiratory rhythm in humans. J. Physiol. (Lond.) 440: 17-33, 1991.
9. DeGoede, J., A. Berkenbosch, C. N. Olievier, and P. H. Quanjer. Ventilatory response to carbon dioxide and apnoeic thresholds. Respir. Physiol. 45: 185-199, 1981.
10. Eldridge, F. L. Central neural respiratory stimulatory effect of active respiration. J. Appl. Physiol. 37: 723-735, 1974.
11. Favier, R., and A. Lacaisse. Hypoxic chemoreflex drive of ventilation in the awake rat. J. Physiol. Paris 74: 411-417, 1978.
12. Feldman, J. L., and H. Gautier. Interaction of pulmonary afferents and pneumotaxic center in control of respiratory pattern in cats. J. Neurophysiol. 39: 31-44, 1976.
13. Fialova, E., M. Vizek, and F. Palecek. Inflation reflex in the rat. Physiol. Bohemoslov. 24: 23-29, 1975.
14. Fukuda, Y. Difference in glossopharyngeal and phrenic inspiratory activities of rats during hypocapnia and hypoxia. Neurosci. Lett. 137: 261-264, 1992.
15. 2 in anaesthetised man. Anesthesiology 22: 393-397, 1961.
16. Henke, K. G., A. Arias, J. B. Skatrud, and J. A. Dempsey. Inhibition of inspiratory muscle activity during sleep. Am. Rev. Respir. Dis. 138: 8-15, 1988.
17. Holub, D., and R. Frank. A system for rapid measurement of lung function in small animals. J. Appl. Physiol. 46: 394-398, 1979.
18. 2 dependence on arterial pH for the respiratory system of dogs. J. Appl. Physiol. 17: 866-890, 1962.
19. 2 for respiratory system in acute hypoxia of dogs. J. Appl. Physiol. 18: 1053-1056, 1963.
20. 2 responsiveness. Am. J. Respir. Dis. 144: 1125-1129, 1991.
21. 2 stimulus threshold for carotid chemoreceptors and breathing. Respir. Physiol. 34: 359-375, 1978.
22. 2 exposure in the rat. J. Appl. Physiol. 45: 611-618, 1978.
23. Leevers, A. M., P. M. Simon, L. Xi, and J. A. Dempsey. Apnoea following normocapnic mechanical ventilation in awake mammals: a demonstration of control system inertia. J. Physiol. (Lond.) 472: 749-768, 1993.
24. 2. J. Auton. Nerv. Syst. 10: 43-54, 1984.
25. Lofaso, F., G. Simonneau, F. L. Ladurie, J. Cerrina, A. Chapelier, F. Brenot, P. Dartevelle, and P. Herve. Frequency of mechanical ventilation and respiratory activity after double lung transplantation. Respir. Physiol. 92: 319-327, 1993.
26. Matsuoka, T., C. Saiki, and J. P. Mortola. Metabolic and ventilatory responses to anemic hypoxia in conscious rats. J. Appl. Physiol. 77: 1067-1072, 1994.
27. Meah, M. S., and W. N. Gardner. Post-hyperventilation apnoea in conscious humans. J. Physiol. (Lond.) 477: 527-538, 1994.
28. Mitchell, R. A., C. R. Bainton, and G. Edelist. Posthyperventilation apnea in awake dogs during metabolic acidosis and hypoxia. J. Appl. Physiol. 21: 1363-1367, 1966.
29. Palecek, F. Measurement of ventilatory mechanics in the rat. J. Appl. Physiol. 27: 149-156, 1969.
30. Phillipson, E. A., R. F. Hickey, C. R. Bainton, and J. A. Nadel. Effect of vagal blockade on regulation of breathing in conscious dogs. J. Appl. Physiol. 29: 475-479, 1970.
31. Prechter, G. C., S. B. Nelson, and R. D. Hubmayr. The ventilatory recruitment threshold for carbon dioxide. Am. Rev. Respir. Dis. 141: 758-764, 1990.
32. Schwieger, I. M., M. Jorge-Costa, G. P. Pizzolato, A. Forster, and D. R. Morel. Intrathecal midazolam reduces isoflurane MAC and increases the apnoeic threshold in rats. Can. J. Anaesth. 41: 144-148, 1994.
33. Shea, S. A. Behavioural and arousal-related influences on breathing in humans. Exp. Physiol. 81: 1-26, 1996.
34. Simon, P. M., D. M. Griffin, D. M. Landry, and J. B. Skatrud. Inhibition of respiratory activity during passive ventilation: a role for intercostal afferents? Respir. Physiol. 92: 53-64, 1993.
35. Simon, P. M., J. B. Skatrud, M. S. Badr, D. M. Griffin, C. Iber, and J. A. Dempsey. Role of airway mechanoreceptors in the inhibition of inspiration during mechanical ventilation in humans. Am. Rev. Respir. Dis. 144: 1033-1041, 1991.
36. Simon, P. M., B. H. Taha, J. A. Dempsey, J. B. Skatrud, and C. Iber. Role of vagal feedback from the lung in hypoxic-induced tachycardia in humans. J. Appl. Physiol. 78: 1522-1530, 1995.
37. Skatrud, J. B., and J. A. Dempsey. Interaction of sleep state and chemical stimuli in sustaining rhythmic ventilation. J. Appl. Physiol. 55: 813-822, 1983.
38. 2-dependent drive of the sympathetic discharge? J. Auton. Nerv. Syst. 3: 401-420, 1981.
39. Yamamoto, W. S., and M. W. Edwards. Homeostasis of carbon dioxide during intravenous infusion of carbon dioxide. J. Appl. Physiol. 15: 807-818, 1960.