Mutation of Thr115 in MyoD positively regulates function in murine fibroblasts and human rhabdomyosarcoma cells

Cell Growth and Differentiation

Volumn 9, Issue 9, 1998, Pages 699-711

  Liu, Linda N ^a   Dias, Peter ^a,b   Houghton, Peter J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b Medinox Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; MUTANT PROTEIN; MYOGENIN; OLIGONUCLEOTIDE; PROTEIN KINASE C; PROTEIN P21; REGULATOR PROTEIN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; GROWTH PROMOTOR; HYBRID PROTEIN; MYOD PROTEIN; THREONINE; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CANCER CELL; CELL DIFFERENTIATION; CELL FUSION; CELL GROWTH; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION REGULATION; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS; ADENOVIRUS; AMINO ACID SUBSTITUTION; ANIMAL; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; GENE VECTOR; GENETICS; GIANT CELL; HUMAN; METABOLISM; MOLECULAR CLONING; MUTATION; PATHOLOGY; PHYSIOLOGY; RHABDOMYOSARCOMA;

ADENOVIRIDAE; ADENOVIRUS E1 PROTEINS; ADENOVIRUS E3 PROTEINS; AMINO ACID SUBSTITUTION; ANIMALS; CELL DIFFERENTIATION; CLONING, MOLECULAR; CULTURE MEDIA; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FIBROBLASTS; GENETIC VECTORS; GIANT CELLS; GROWTH SUBSTANCES; HUMANS; MUTATION; MYOD PROTEIN; RECOMBINANT FUSION PROTEINS; RHABDOMYOSARCOMA; THREONINE;

EID: 0031595038     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Emerson, C. P. Myogenesis and developmental control genes. Curr. Biol., 2: 1065-1075, 1990.
2. Lassar, A., and Munsterberg, A. Wiring diagram: regulation circuits and the control of skeletal myogenesis. Curr. Biol., 6: 432-442, 1994.
3. Olson, E. N. Interplay between proliferation and differentiation within the myogenic lineage. Dev. Biol., 154: 261-272, 1992.
4. Weintraub, H., Davis, R., Tapscott, S., Thayer, M., Krause, M., Benezra, R., Blackwell, T. K., Turner, D., Rupp, R., Hollenberg, S., Zhuang, Y., and Lassar, A. The MyoD gene family: nodal point during specification of muscle cell lineage. Science (Washington DC), 251: 761-766, 1991.
5. Weintraub, H. The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell, 75: 1241-1244, 1993.
6. Davis, R. L., Weintraub, H., and Lassar, A. B. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell, 51: 987-1000, 1987.
7. Weintraub, H., Tapscott, S. J., Davis, R. L., Thayer, M. J., Adam, M. A., Lassar, A. B., and Miller, A. D. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc. Natl. Acad. Sci. USA, 86: 5434-5438, 1989.
8. Davis, R. L., Chang, P-F., Lassar, A. B., and Weintraub, H. The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation. Cell, 60: 733-746, 1990.
9. Lassar, A. B., Buskin, J. M., Lockshon, D., Davis, R. L., Apone, S., Hauschka, S. D., and Weintraub, H. MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer. Cell, 58: 823-831, 1989.
10. Hu, J. S., Olson, E. N., and Kingston R. E. HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA binding ability of myogenic regulatory factors. Mol. Cell. Biol., 72: 1031-1042, 1992.
11. Lassar, A. B., Davis, R. L., Wright, W. E., Kadesch, T., Murre, C., Voronova, A., Baltimore, D., and Weintraub, H. Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like protein in vivo. Cell, 66: 305-315, 1991.
12. Halvey, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D., and Lassar, A. B. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science (Washington DC), 267: 1018-1021, 1995.
13. Guo, K., Wang, J., Andres, V., Smith, R. C., and Walsh, K. MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation. Mol. Cell. Biol., 15: 3823-3829, 1995.
14. Olson, E. N. MyoD family: a paradigm for development? Genes Dev., 4: 1454-1461, 1990.
15. Vaidya, T. B., Rhodes, S. J., Taparowsky, E. J., and Konieczny, S. F. Fibroblast growth factor and transforming growth factor β represses transcription of the myogenic regulatory gene MyoD1. Mol. Cell. Biol., 9: 3576-3579, 1989.
16. Alema, S., and Tato, F. Oncogenes and muscle differentiation: multiple mechanisms of interference. Semin. Cancer Biol., 5: 147-156, 1994.
17. Bengal, E., Ransone, L., Scharfmann, R., Dwarki, V. J., Tapscott, S. J., Weintraub, H., and Verma, I. M. Functional antagonism between c-Jun and MyoD proteins: a direct physical association. Cell, 68: 507-519, 1992.
18. Li, L., Chambard, J. C., Karin, M., and Olson, E. N. Fos and Jun repress transcriptional activation by myogenin and myoD: the amino terminus of Jun can mediate repression. Genes Dev., 6: 676-689, 1992.
19. Benezra, R., Davis, R. L., Lockshon, D., Turner, D. L., and Weintraub, H. The protein Id: a negative regulator of helix-loop-helix DNA binding protein. Cell, 61: 49-59, 1990.
20. Christy, B. A., Sanders, L. K., Lau, L. F., Copeland, N. G., Jenkins, N. A., and Nathans, D. An Id-related helix-loop-helix protein encoded by growth factor-inducible gene. Proc. Natl. Acad. Sci. USA, 88: 1815-1819, 1991.
21. Jen, Y., Weintraub, H., and Benezra, R. Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins. Genes Dev., 6: 1466-1479, 1992.
22. Sun, X. H., Copeland, N. G., Jenkins, N. A., and Baltimore, D. Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol. Cell. Biol., 11: 5603-5611, 1991.
23. Spicer, D. B., James, R., Cheung, W. L., and Lassar, A. B. Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist. Science (Washington DC), 272: 1476-1480, 1996.
24. Chen, C. M. A., Kraut, N., Groudine, M., and Weintraub, H. l-mf, a novel myogenic repressor, interacts with members of the MyoD family. Cell, 86: 731-741, 1996.
25. Bennett, A. M., and Tonkes, N. K. Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases. Science (Washington DC), 278: 1288-1291, 1997.
26. Enkemann, S. A., Konieczny, S. F., and Taparowsky, E. J. Adenovirus 5 E1 a represses muscle-specific enhancers and inhibits expression of the myogenic regulatory factor genes. MyoD1 and myogenin. Cell Growth Differ., 1: 628-640, 1990.
27. Sandmoller, A., Meents, H., and Arnold, H. H. A novel E1A domain mediates skeletal-muscle-specific enhancer repression independently of pRB and p300 binding. Mol. Cell. Biol., 16: 5846-5856, 1996.
28. Lassar, A. B., Thayer, M. J., Overell, R. W., and Weintraub, H. Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1. Cell, 58: 659-667, 1989.
29. val inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix-loop-helix factors. Mol. Cell. Biol., 15: 5205-5213, 1995.
30. Biegel, J. A., Nyum, L. M., Valentine, V., Barr, F. G., and Shapiro, D. N. Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization. Genes Chromosomes Cancer, 12: 186-192, 1995.
31. Scheildler, S., Fredericks, W. J., Rauscher, F. J., III, Barr, F. G., and Vogt, P. K. The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture. Proc. Natl. Acad. Sci. USA, 93: 9805-9809, 1996.
32. Epstein, J. A., Lam, P., Jepeal, L., Maas, R. L., and Shapiro, D. N. Pax3 inhibits myogenic differentiation of cultured myoblast cells. J. Biol. Chem., 270: 11719-11722, 1995.
33. Li, L., Zhou, J., James, G., Heller-Harrison, R., Czech, M. P., and Olson, E. N. FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains. Cell, 77: 1181-1194, 1992.
34. Ma, P. C. M., Rould, M. A., Weintraub, H., and Pabo, C. O. Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation. Cell, 77: 451-459, 1994.
35. Douglass, E. C., Valentine, M., Etcubanas, E., Parham, D., Webber, B. L., Houghton, P. J., Houghton, J. A., and Green, A. A. A specific chromosomal abnormality in rhabdomyosarcoma. Cytogenet. Cell Genet., 45: 148-155, 1987.
36. Zhang, W-W., Kock, P. E., and Roth, J. A. Detection of wild-type contamination in a recombinant adenoviral preparation by PCR. BioTechniques, 18: 444-447, 1995.
37. Dias, P., Pharham, D. M., Shapiro, D. N., Tapscott, S. J., and Houghton, P. J. Monoclonal antibodies to the myogenic regulatory protein MyoD1: epitope mapping and diagnostic utility. Cancer Res., 52: 6431-6439, 1992.
38. Skapek, S. X., Rhee, J., Spicer, D. B., and Lassar, A. B. Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science (Washington DC), 267: 1022-1024, 1995.
39. Dias, P., Pharham, D. M., Shapiro, D. N., Webber, B. L., and Houghton, P. J. Myogenic regulatory protein (MyoD1) expression in childhood solid tumors: diagnostic utility in rhabdomyosarcomas. Am. J. Pathol., 137: 1283-1291, 1990.
40. Anand, G., Shapiro, D. N., Dickman, P. S., and Prochownik, E. V. Rhabdomyosarcomas do not contain mutations in the DNA binding domains of myogenic transcription factors. J. Clin. Investig., 93: 5-9, 1994.
41. Otten, A. D., Firpo, E. J., Gerber, A. N., Brody, L. L., Roberts, J. M., and Tapscott, S. J. Inactivation of MyoD-mediated expression of p21 in tumor cell lines. Cell Growth Differ., 8: 1151-1160, 1997.
42. Hardy, S., Kong, Y., and Konieczny, S. F. Fibroblast growth factor inhibits MRF4 activity independently of the phosphorylation status of a conserved threonine residue within the DNA-binding domain. Mol. Cell. Biol., 13: 5943-5956, 1993.
43. Tapscott, S. J., Thayer, M. J., and Weintraub, H. Deficiency in rhabdomyosarcomas of a factor required for MyoD activity and myogenesis. Science (Washington DC), 259: 1450-1453, 1993.
44. Hiti, A. L., Bogenmann, E., Gonzales, F., and Jones, P. A. Expression of the MyoD1 muscle determination gene defines differentiation capability but not tumorigenicity of human rhabdomyosarcomas. Mol. Cell. Biol., 9: 4722-4730, 1989.
45. Shapiro, D. N., Houghton, P. J., Hazelton, B. J., Germain, G. S., Murti, K. G., Rahman, A., and Houghton, J. A. Morphologic and molecular characterization of spontaneous myogenic differentiation in a human rhabdomyosarcoma cell line. Cancer Res., 50: 6002-6009, 1990.
46. El-Badry, O. M., Minniti, C., Kohn, E. C., Houghton, P. J., Daughaday, W. H., and Helman, L. J. Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors. Cell Growth Differ., 1: 325-331, 1990.
47. Shapiro, D. N., Johns, B. G., Shapiro, L. H., Dias, P., and Houghton, P. J. Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppressed the malignant phenotype of a human alveolar rhabdomyosarcoma. J. Clin. Investig., 94: 1235-1242, 1994.
48. Thulasi, R., Dias, P., Houghton, P. J., and Houghton, J. A. α2a-Interferon-induced differentiation of human alveolar rhabdomyosarcoma cells: correlation with down-regulation of the insulin-like growth factor type I receptor. Cell Growth Differ., 7: 531-541, 1996.