2@?,3@?-Dideocytidine is a potent inducer of apoptosis in glioblastoma cells

Anticancer Research

Volumn 18, Issue 3 A, 1998, Pages 1859-1863

  Ullyatt, Elizabeth ^a   Liang, Bertrand C ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

ddC; Glioblastoma; Mitochondria

Indexed keywords

GLUCOSE; PYRUVIC ACID; URIDINE; ZALCITABINE; ANTIMETABOLITE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; CELL CULTURE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECT; KINETICS; TIME;

ANTIMETABOLITES; APOPTOSIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLIOBLASTOMA; HUMANS; KINETICS; TIME FACTORS; TUMOR CELLS, CULTURED; ZALCITABINE;

EID: 0031594952     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Liang BC and Liang DM: Primary Central Nervous System Neoplasms. In: A Practical Approach to Clinical Neurology. J. Biller, ed. Lippincott, Phibdelphin.
2. Warburg O, Wind F and Negelein E: Uber den Stoffwechsel von Tumoren im Korper. Klin Woch 5: 829-832, 1926.
3. Lichtor T, and Dohrmann GJ: Oxidative metabolism and glycolysis in benign brain tumors. J Neurosurgery 67: 336-340, 1987.
4. Oudard S, Poirson F, Miccoli L, Bourgeois Y, Vassault A, Poisson M, Magdelenat H, Dutrillaux B and Poupon M-F: Mitochondria-bound hexokinase as target for therapy of malignant gliomas. Inter J Cancer 62: 1-7, 1995.
5. Liang BC and Hays L: Mitochondrial DNA copy number changes in human gliomas. CancerLetters 105: 167-173, 1996.
6. Liang BC: Evidence for association of mitochondrial DNA sequence amplification and nuclear localization in human low-grade gliomas. Mutation Res 354: 127-133, 1996.
7. 2: Evidence for mitochondrial involvement. Cancer Res 54: 1497-1502, 1994.
8. Andrews PA, and Albright KD: Mitochondrial defects in cis-diamminedichloroplatinum (II)-resistant human ovarian carcinoma cells. Cancer Res 52: 1895-1901, 1992.
9. Liang BC, and Ullyatt E: Tyrphostin AG17 chemosensitizes glioblastoma cells to BCNU by a mitochondrially-mediated mechanism. Clinical Cancer Res in press.
10. Kukhanova M, Liu SH, Mozzherin D, Lin TS, Chu CK, and Cheng YC: L-and D-enantiomers of 2', 3'-dideoxycytidine 5'-triphosphate analogs as substrates for human DNA polymerases. Implications for the mechanism of toxicity. J Biol Chem 270: 23055-23059, 1995.
11. Medina DJ, Tsai CH, Hsiung GD and Cheng YC: Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides. Antimicrobial Agents and Chemotherapy 38: 1824-1828, 1994.
12. Kruse CA, Variela-Garcia M, Kleinschmidt-Demasters BK, Owens GC, Spector EB, Habib F, SaVelieva E and Liang BC: Receptor expression, cytogenetic, and molecular analysis of six continuous human glioma cell lines. In Vitro Cell Dev Biol, in press.
13. Kruse C, Mitchell DH, Kleinschmidt-DeMasters BK, Franklin WA, Morse HG, Spector EB and Lillehei KO: Characterization of a continuous human glioma cell line DBTRG-05MG: Growth kinetics, karyorype, receptor expression, and tumor suppressor gene analyses. In Vitro Cell Dev Biol 28A: 609-614, 1992.
14. Schwartz LM, Milligan CE, Bielke W and Robinson SJ: Cloning Cell Death Genes. Cell Death 1995; Chapter 7: I-V. Academic Press.
15. Polla BS, Kantengwa S, Francois D, Salvioli S, Franceschi C, Marsac C, and Cossarizza A: Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. Proc Natl Acad Sci USA 93: 6458-6.463, 1996.
16. Schwartz LM, Milligan CE, Bielke W and Robinson SJ: Cloning Cell Death Genes. Cell Death 1995; Chapter 7: I-V. Academic Press.
17. Cavalli LR and Liang BC: Mutagenesis, tumorigenicity and apoptosis: Are the mitochondriainvolved? Mutation Res, in press.
18. King MP, and Attardi G: Isolation of human cell lines lacking mitochondrial DNA. Methods in Enzymology: Mitochondrial Biogenesis and Genetics 264: 304-313, 1996. Academic Press, Inc.
19. Sandberg JA, and Slikker W Jr. Developmental pharmacology and toxicology of anti-HIV therapeutic agents: dideoxynucleosides. FASEB J 9: 1157-1163, 1995.
20. Morse DE, Davis HD, Popke EJ, Brown KJ, O'Donoghue VA, and Grunberg NE: Effects of ddC and AZT on locomotion and acoustic startle. I: Acute effects in female rats. Pharmacology, Biochemistry and Behavior 56: 221-228, 1997.