Action of the 5-HT(2A) antagonist amperozide on alcohol-induced poikilothermia in rats

Pharmacology Biochemistry and Behavior

Volumn 59, Issue 1, 1998, Pages 91-95

  Myers, R D ^a   Lankford, M ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

5 HT(2A) receptors Dopamine; Alcohol; Amperozide; Ethanol; Hyperthermia; Hypothalamus; Hypothermia; Serotonin; Thermoregulation

Indexed keywords

ALCOHOL; AMPEROZIDE; DOPAMINE; SEROTONIN; SEROTONIN 2A ANTAGONIST; PIPERAZINE DERIVATIVE; SEROTONIN ANTAGONIST;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRINKING BEHAVIOR; HYPERTHERMIA; HYPOTHALAMUS; HYPOTHERMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM; SUBCUTANEOUS DRUG ADMINISTRATION; THERMOREGULATION; ALCOHOLISM; ANIMAL; DRUG EFFECT; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ALCOHOLISM; ANIMALS; BODY TEMPERATURE REGULATION; MALE; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN ANTAGONISTS;

EID: 0031594874     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(97)00330-4     Document Type: Article

References (35)

1. 2 receptors mediate hypo- and hyperthermic effects of tryptophan in pargyline-pretreated rats. Pharmacol. Biochem. Behav. 52:1995;379-384.
2. 2 receptor. Br. J. Pharmacol. 107:1992;1008-1112.
3. Finn D., Syapin P., Bejanian M., Jones B., Alkana R. Temperature dependence of ethanol depression in mice. Dose response Alcohol. Clin. Exp. Res. 18:1994;382-386.
4. 1A receptors Eur. J. Pharmacol. 237:1993;283-291.
5. Foreman M. M., Fuller R., Nelson D., Calligaro D., Kurz K., Misner J., Garbrecht W., Parli C. Preclinical studies on LY237733, a potent and selective serotonergic antagonist. J. Pharmacol. Exp. Ther. 260:1992;51-57.
6. Freund G. Ethanol-induced changes in body temperature and their neurochemical consequences. Majchrowicz E., Noble E. P. Biochemistry and pharmacology of ethanol, vol. 2. 1979;439-452 Plenum Press, New York.
7. Ginefri-Gayet M., Gayet J. Involvement of serotonin receptors in methionine sulfoximine-induced hypothermia in the rat. Eur. J. Pharmacol. 217:1992;85-91.
8. Gudelsky G., Koenig J., Meltzer H. Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Neuropharmacology. 25:1986;1307-1313.
9. Hadrava V., Blier P., Dennis T., Ortemann C., de Montigny C. Characterization of 5-hydroxytryptamine 1A properties of flesinoxan. In vivo electrophysiology and hypothermia study Neuropharmacology. 34:1995;1311-1326.
10. Kimura K., Nomikos G., Svensson T. Effects of amperozide on psychostimulant-induced hyperlocomotion and dopamine release in the nucleus accumbens. Pharmacol. Biochem. Behav. 44:1993;27-36.
11. Lopez-Valpuesta F. J., Nyce J. W., Griffin T., Ice J., Myers R. D. Antisense to NPY-Y1 demonstrates that Y1 receptors in the hypothalamus underlie NPY hypothermia and feeding in rats. Proc. R. Soc. Lond. [Biol.]. 263:1996;881-886.
12. 2 receptors induces malignant hyperthermia Naunyn Schmiedebergs Arch. Pharmacol. 341:1990;483-493.
13. 1B receptors? J. Neural Transm. 73:1988;43-55.
14. 2A receptors. Psychopharmacology (Berlin). 117:1995;193-199.
15. 1A receptor-mediated hypothermia in mice; Absence of spare receptors and rapid induction of tolerance. Pharmacol. Biochem. Behav. 43:1992;405-411.
16. 1A receptor-mediated activity in the rat. A pharmacological characterization of the actions of novel agonists and antagonists J. Pharmacol. Exp. Ther. 264:1993;1364-1376.
17. Myers R. D. Hypothalamic control of thermoregulation. Neurochemical mechanisms Morgane P., Panksepp J. Handbook of the hypothalamus, vol. 3. 1980;83-210 Marcel Dekker, New York.
18. Myers R. D. Alcohol's effect on body temperature. Hypothermia, hyperthermia, or poikilothermia Brain Res. Bull. 7:1981;209-220.
19. 2 receptor antagonist, ritanserin, to alter preference for alcohol in drinking rats. Pharmacol. Biochem. Behav. 45:1993;233-237.
20. Myers R. D., Lankford M. Suppression of alcohol preference in high alcohol drinking rats. Efficacy of amperozide vs. naltrexone. Neuropsychopharmacology. 14:1996;139-149.
21. Myers R. D., Lee T. Neurochemical aspects of thermoregulation. Wang L. Advances in comparative and environmental physiology. 1989;161-203 Springer Verlag, Heidelberg.
22. Myers R. D., Ruwe W. D. Is alcohol induced poikilothermia mediated by 5-HT and catecholamine receptors or by ionic set-point mechanisms in the brain? Pharmacol. Biochem. Behav. 16:1982;321-327.
23. Myers R. D., Lankford M., Björk A. Selective reduction by the 5-HT antagonist amperozide of alcohol preference induced in rats by systemic cyanamide. Pharmacol. Biochem. Behav. 43:1992;661-667.
24. 2 receptor blockade by amperozide suppressed ethanol drinking in genetically preferring (P) rats. Pharmacol. Biochem. Behav. 45:1993;741-747.
25. Nakane T., Kawai K., Chiba S. Mechanism of pindolol-induced vasoconstriction in isolated and perfused dog coronary arteries. Jpn. J. Pharmacol. 62:1993;67-74.
26. 2 receptor-mediated temperature and corticosterone responses. Pharmacol. Biochem. Behav. 33:1989;781-785.
27. 1A receptor activation. Br. J. Pharmacol: 106:1992;603-609.
28. Paez X., Myers R. D. Alcohol-induced poikilothermia, sleep and motor impairment. Actions on brain of EGTA and verapamil Alcohol. 6:1989;489-498.
29. Paez X., Myers R. D. Differential actions of RO15-1788 and diazepam on poikilothermia, motor impairment and sleep produced by ethanol. Pharmacol. Biochem. Behav. 36:1990;915-922.
30. Parsons A. A., Whalley E. T. Characterization of the 5-hydroxytryptamine receptor which mediates contraction of the human isolated basilar artery. Cephalalgia (Suppl.). 9:1989;47-51.
31. Rawadi C., Davy M., Midol-Monnet M., Cohen Y. Biochemical characterization of the mechanisms involved in the 5-hydroxytryptamine-induced increase in rat atrial rate. Biochem. Pharmacol. 48:1994;683-688.
32. Salmi P., Karlsson T., Ahlenius. S Antagonism by SCH 23390 of clozapine-induced hypothermia in the rat. Eur. J. Pharmacol. 253:1994;67-73.
33. 2 receptors. Brain Res. 529:1990;85-90.
34. 1A agonists. J. Pharmacol. Exp. Ther. 270:1994;198-208.
35. 2 receptors in rat aorta. Artery. 18:1990;47-53.