Effect of variability in hepatic clearance on the bioequivalence parameters of a drug and its metabolite: Simulations using a pharmacostatistical model

Pharmaceutica Acta Helvetiae

Volumn 73, Issue 3, 1998, Pages 135-144

  Rosenbaum, Sara E ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Bioavailability; Bioequivalence; Pharmacokinetics; Population pharmacokinetics

Indexed keywords

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; COMPUTER SIMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; GENETIC VARIABILITY; INTRAVENOUS DRUG ADMINISTRATION; LIVER CLEARANCE; LIVER METABOLISM; ORAL DRUG ADMINISTRATION; STATISTICAL MODEL; BIOLOGICAL MODEL; DRUG APPROVAL; HUMAN; LIVER; METABOLIC CLEARANCE RATE; METABOLISM; PHARMACOKINETICS;

DRUG;

AREA UNDER CURVE; DRUG APPROVAL; HUMANS; LINEAR MODELS; LIVER; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; MODELS, STATISTICAL; PHARMACEUTICAL PREPARATIONS; THERAPEUTIC EQUIVALENCY;

EID: 0031594862     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(98)00008-9     Document Type: Article

References (10)

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