FcγRIIb inhibits both B cell receptor- and CD19-induced Ca2+ mobilization in FcγR-transfected human B cells

International Immunology

Volumn 10, Issue 2, 1998, Pages 141-146

  Koncz, Gábor ^b   Gergely, János ^b   Sármay, Gabriella ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

CD19; Fc receptors; Human B cells; Regulation; Signal transduction

Indexed keywords

CALCIUM ION; CD19 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; FC RECEPTOR; CALCIUM; LYMPHOCYTE ANTIGEN RECEPTOR;

ARTICLE; B LYMPHOCYTE; CALCIUM MOBILIZATION; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOMA CELL LINE; PRIORITY JOURNAL; CAPPING PHENOMENON; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANTIGENS, CD19; B-LYMPHOCYTES; CALCIUM; HUMANS; RECEPTOR AGGREGATION; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, IGG; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0031594703     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.2.141     Document Type: Article

References (26)

1. D'Ambrosio, D., Hippen, K. H., Minskoff, S. A., Mellman, I., Pani, G., Siminovitch, K. A. and Cambier, J. C. 1995. Recruitment and activation of PTP1C in negative regulation of antigen receptor signalling by FcγRIIB1. Science 268:293.
2. D'Ambrosio, D., Fong, D. C. and Cambier, J. C. 1996. The SHIP phosphatase becomes associated with FcγRIIB1 and is tyrosine phosphorylated during negative signalling. Immunol. Lett. 54:77.
3. Ono, M., Bolland, S., Tempst, P. and Ravetch, J. V. 1996. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB. Nature 383:263.
4. Fong, D. C., Malbec, O., Arock, M., Cambier, J. C., Fridman, W. H. and Daeron, M. 1996. Selective in vivo recruitment of the phosphatidyinositol phosphatase SHIP by phosphorylated FcγRIIB during negative regulation of IgE-dependent mouse mast cell activation. Immunol. Lett. 54:83.
5. ras-dependent pathway. J. Biol. Chem. 271:30499.
6. Sármay, G., Koncz, G. and Gergely, J. 1996. Integration of activatory and inhibitory signals in human B-cells. Immunol. Lett. 54:93.
7. Sármay, G., Koncz, G., Pecht, I. and Gergely, J. 1997. Fcγ receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell. Immunol. Lett. 57:159.
8. Nadler, M. J. S., Chen, B., Anderson, J. S., Wortis, H. H. and Neel, B. G. 1997. Protein tyrosine phosphatase SHP-1 is dispensable for FcγRIIB-mediated inhibition of B cell antigen receptor activation. J. Biol. Chem. 272:20038.
9. Tridandapani, S., Chacko, G. W., Van Brocklyn, J. R. and Coggeshall, K. M. 1997. Negative signalling in B cells causes reduced Ras activity by reducing Shc-Grb2 interactions. J. Immunol. 158:1125.
10. Kavanagh, W. M., Pto, D. A., Chin, S. M., Deuter-Reinhard, M., Jefferson, A. B., Morris, F. A., Masiarz, F. R. Cusens, L. S., Majerus, P. W. and Williams, L. T. 1996. Multiple forms of an inositol polyphosphate 5′-phosphatase form signalling complexes with She and Grb2. Curr. Biol. 6:438.
11. Jackson, S. P., Schoenwaelder, S. M., Matzaris, M., Brown, S. and Mitchell, C. A. 1995. Phosphatidyl inositol 3,4,5-trisphosphate is a substrate for the 75 kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/ p110 form of phosphoinositide 3-kinase. EMBO J. 14:4490
12. Ravetch, J V. 1997. Fc receptors. Curr Biol. 9:121.
13. 2 is inhibited. Biochem. J. 319:913.
14. Diegel, M. L., Rankin, B. M., Bolen, J. B., Dubois, P. M. and Kiener, P. A. 1994. Cross-linking of Fc gamma receptor to surface immunoglobulin on B cells provides an inhibitory signal that closes the plasma membrane calcium channel. J. Biol. Chem. 269:11409.
15. Clapham, D. E. 1995. Calcium signalling. Cell 80:259.
16. Berridge, M. J. 1993. Inositol triphosphate and calcium signalling. Nature 361:315.
17. 2+ channel. Nature 355:356
18. Theibert, A. B., Estevez, V. A., Ferris, C. D., Danoff, S. K.,. Barrow, R. K., Prestwich, G. D. and Snyder, S. H. 1991. Inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate receptor proteins: isolation and characterization from rat brain. Proc. Natl Acad. Sci. USA 88:3165.
19. Salim, K., Bottomley, M. J., Querfurth, E., Zvelebil, M. J., Gout, I., Scaife, R., Margolis, R. L. Gigg, R., Smith, C. I. E., Driscoll, P. C., et al. 1996. Distinct specificity in the recognition of phosphoinositides by the plecstrin homology domains of dynamin and Brutons tyrosine kinase. EMBO J. 15:6241.
20. Sarkar, S., Schlottmann, K., Cooney, D, and Coggeshall, K. M. 1996. Negative signalling via FcγRllb1 in B cells blocks phospholipase Oγ2 tyrosine phosphorylation but not Syk or Lyn activation. J. Biol. Chem. 1996.271:20182.
21. Carter, R. H. and Fearon, D. T. 1992. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256:105.
22. Tuveson, D. A., Carter, R. H., Soltoff, S. P. and Fearon, D. T. 1993. CD19 of B cells as a surrogate kinase insert region to bind phosphatidyl inositol-3 kinase. Science 260:986.
23. Fearon, D. T. and Carter, R. H. 1995. The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity. Annu. Rev. Immunol. 13:127.
24. Tedder, T. F. Inaoki, M. and Sato, S. 1997. The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. Immunity 6:107.
25. Heyman, B. 1996. Complement and Fc-receptors in regulation of the antibody response. Immunol. Lett. 54:195.
26. Daeron, M. 1996. Building up the family of ITIM-bearing negative co-receptors. Immunol. Lett. 54:73.