Effects of CO2 and pH on the spinal respiratory rhythm generator in vitro

Brain Research Bulletin

Volumn 45, Issue 1, 1998, Pages 83-87

  Dubayle, David ^a   Viala, Denise ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

CO2 and H+ chemosensitivity; In vitro; Newborn rats; Spinal chemoreceptors; Spinal respiratory activity

Indexed keywords

5 HYDROXYTRYPTOPHAN; AMPHETAMINE; CARBON DIOXIDE; ETHER; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; POTASSIUM; PROTON; N METHYLASPARTIC ACID;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CHEMORECEPTOR; CHEMOSENSITIVITY; CONTROLLED STUDY; NEWBORN; NONHUMAN; PH; PRIORITY JOURNAL; RAT; RESPIRATION CENTER; RESPIRATION CONTROL; RESPIRATORY BURST; SPINAL CORD; SPINAL CORD TRANSSECTION; ANIMAL; BREATHING; DRUG EFFECT; ELECTROPHYSIOLOGY; FEMALE; IN VITRO STUDY; METHODOLOGY; PHYSIOLOGY; SPINAL ROOT; SPRAGUE DAWLEY RAT; TIME;

5-HYDROXYTRYPTOPHAN; AMPHETAMINE; ANIMALS; ANIMALS, NEWBORN; CARBON DIOXIDE; ELECTROPHYSIOLOGY; FEMALE; GLUTAMIC ACID; HYDROGEN-ION CONCENTRATION; N-METHYLASPARTATE; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATION; RESPIRATORY CENTER; SPINAL CORD; SPINAL NERVE ROOTS; TIME FACTORS;

EID: 0031594625     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(97)00304-3     Document Type: Article

References (19)

1. Aoki M., Kasaba T., Kurosawa Y. Properties of respiratory neurons in the upper cervical cord of the cat. Neurosci. Lett. (Suppl.). 13:1983;59.
2. Cowley K. C., Schmidt B. J. Regional distribution of the locomotor pattern-generating nework in the neonatal rat spinal cord. J. Neurophysiol. 77:1997;247-259.
3. Dubayle D., Viala D. Existence possible d'une activité inspiratoire spinale sur préparation in vitro tronc cérébral-moelle de rat nouveau-né C. R. Acad. Sci. Paris Sci. Life Sci. 316:1993;1458-1462.
4. Dubayle D., Viala D. Localization of the spinal respiratory rhythm generator by an in vitro electrophysiological approach. Neuroreport. 7:1996;1175-1180.
5. Dubayle D., Viala D. Interactions between medullary and spinal respiratory rhythm generators in the in vitro brainstem spinal cord preparation from newborn rats. Exp. Brain Res. 109:1996;1-8.
6. Funk G. D., Smith J. C., Feldman J. L. Generation and transmission of respiratory oscilations in medullary slices Role of excitatory amino acids . J. Neurophysiol. 70:1993;1497-1515.
7. Harada Y., Kuno M., Wang Y. Z. Differential effects of carbon dioxide and pH on the central chemoreceptors in the rat in vitro. J. Physiol. (Lond.). 368:1985;679-693.
8. 2 in the rat respiratory center in vitro. Brain Res. 333:1985;336-339.
9. Langendorff O., Nitchmann R. Stüdien über die Innervation des Athembewegungen. I. Über die spinalen Centren des Athmung. Arch. Physiol. 4:1880;518-549.
10. Lipski J., Duffin J., Kruszewska B., Zhang X. Upper cervical inspiratory neurons in the rat electrophysiological and morphological study. Exp. Brain Res. 95:1993;477-487.
11. Morin D., Monteau R., Hilaire G. 5-Hydroxytryptamine modulates central respiratory activity in the newborn rat An in vitro study . Eur. J. Pharmacol. 192:1991;89-95.
12. Okada Y., Mückenhoff K., Scheid P. Hypercapnia and medullary neurons in the isolated brain stem-spinal cord of the rat. Respir. Physiol. 93:1993;327-336.
13. Richter D. W., Ballanyi K., Schwarzacher S. W. Mechanisms of respiratory rhythm generation. Curr. Opin. Neurobiol. 281:1992;788-793.
14. Rokitanski C., Wertheimer B. Sur les centres respiratoires de la moelle épinière. C. R. Soc. Biol. 38:1886;34-36.
15. Sawchenko, P. E. A tale of three peptides: Corticotropin-releasing factor, oxytocin and vasopressin containing pathways mediating integrated hypothalamic responses to stress. Stress Neuropept. Syst. Dis. 3-17; 1991.
16. Smith J. C., Ellenberger H. H., Ballanyi K., Richter D. W., Feldman J. L. Pre-Bötzinger complex A brainstem region that may generate respiratory rhythm in mammals . Science. 254:1991;726-729.
17. Suzue T. Respiratory rhythm generation in the in vitro brainstem-spinal cord preparation of the neonatal rat. J. Physiol. (Lond.). 354:1984;173-183.
18. Viala D., Freton E. Evidence for respiratory and locomotor pattern generators in the rabbit cervico-thoracic cord and for their interactions. Exp. Brain Res. 49:1983;247-256.
19. Viala D., Perségol L., Palisses R. The spinal respiration generators Chemical and neurogenic regulation of their activity . Benchetrit G., Demongeot J. Concepts and formalizations in the control of breathing. 1987;361-376 Manchester University Press, Manchester.