Changes in urinary 6β-hydroxycortisol/cortisol ratio after birth in human neonates

European Journal of Clinical Pharmacology

Volumn 53, Issue 5, 1998, Pages 343-346

  Nakamura, H ^a   Hirai, M ^a   Ohmori, S ^a   Ohsone, Y ^b   Obonai, T ^a   Sugita, K ^a   Niimi, H ^a   Kitada, M ^a  

^a CHIBA UNIVERSITY HOSPITAL   (Japan)

^b KIMITSU CHUO HOSPITAL   (Japan)

Author keywords

CYP3A; Neonates

Indexed keywords

6BETA HYDROXYHYDROCORTISONE; HYDROCORTISONE; 6 BETA-HYDROXYCORTISOL; CYTOCHROME P450; CYTOCHROME P450 3A; DRUG DERIVATIVE; N DEMETHYLASE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BIRTH WEIGHT; CESAREAN SECTION; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; GENDER; GESTATIONAL AGE; HUMAN; JAPAN; MALE; NEWBORN; PREMATURITY; PRIORITY JOURNAL; URINE; VAGINAL DELIVERY; INFANT; METABOLISM; SEX DIFFERENCE;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; HYDROCORTISONE; INFANT; MALE; OXIDOREDUCTASES, N-DEMETHYLATING; SEX FACTORS;

EID: 0031594181     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050390     Document Type: Article

References (21)

1. Watkins PB, Wrighton SA, Maurel P, Schuetz EG, Mendez-Picon G, Parker GA, Guzelian PS (1985) Identification of an inducible form of cytochrome P-450 in human liver. Proc Natl Acad Sci USA 82: 6310-6314
2. Combalbert J, Faber I, Faber G, Dalet I, Derancourt J, Cano JP, Maurel P (1989) Metabolism of cyclosporin A; IV: purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450 III A gene subfamily. Drug Metab Dispos 17: 197-207
3. Kronbach T, Fischer V, Meyer UA (1988) Cyclosporine metabolism in human liver: identification of a cytochrome P450 III A gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin Pharmacol Ther 43: 630-635
4. Guengerich FP, Brian WR, Iwasaki M, Sari MA, Baarhielm C, Berntsson P (1991) Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P450 III A4. J Med Chem 34: 1838-1844
5. Kronbach T, Mathys D, Umeno M, Gonzalez FJ, Meyer UA (1989) Oxidation of midazolam and triazolam by human liver cytochrome P450 III A4. Mol Pharmacol 36: 89-96
6. Yun CH, Okerholm RA, Guengerich FP (1993) Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Drug Metab Dispos 21: 403-409
7. Waxman DJ, Attisano C, Guengerich FP, Lapenson DP (1988) Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme. Arch Biochem Biophys 263: 424-436
8. Wrighton SA, Brian WR, Sari M.-A, Iwasaki M, Guengerich FP, Raucy JL, Molowa DT, Vandenbranden M (1990) Studies on the expression and metabolic capabilities of human liver cytochrome P450 III A5(HLp3). Mol Pharmacol 38: 207-213
9. Raucy JL, Carpenter SJ (1993) The expression of xenobiotic-metabolizing cytochromes P450 in fetal tissues. J Pharmacol Toxicol Methods 29: 121-128
10. Watkins PB, Murray SA, Winkelman LG, Heuman DM, Wrighton SA, Guzelian PS (1989) Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Study in rats and patients. J Clin Invest 83: 688-697
11. May DG, Porter J, Wilkinson GR, Branch RA (1994) Frequency distribution of dapsone N-hydroxylase a putative probe for P4503A4 activity, in a white population. Clin Pharmacol Ther 55: 492-500
12. Zhiri A, Wellman-Bednawska M, Siest G (1986) Elisa of 6β-hydroxycortisol in human urine: diurnal variations and effects of antiepileptic therapy. Clin Chimica Acta 157: 267-276
13. Desager JP, Dumont E, Harvengt C (1987) The urinary 6β-hydroxycortisol excretion in man on inducers and inhibitors of the hepatic mixed function oxidase. Pharmacol Ther 33: 197-199
14. Ohnhaus EE, Breckenridge AM, Park BK (1989) Urinary excretion of 6β-hydroxycortisol and the time course measurement of enzyme induction in man. Eur J Clin Pharmacol 36: 39-46
15. Tomlinson B, Young RP, Ng MCY, Anderson PJ, Kay R, Critchley JAJH (1996) Selective liver enzyme induction by carbamazepine and phenytoin in Chinese epileptics. Eur J Clin Pharmacol 50: 411-415
16. Nakamura H, Yamagata S, Sawai M, Nakamura H, Ohmori S, Kitada M (1997) Effect of grapefruit juice on urinary 6β-OHF C ratio. Jpn J Hosp Pharmac 23: 134-139
17. Bienvenu T, Rev E, Pons G, D'Athis P (1991) A simple non-invasive procedure for the investigation of cytochrome P-450 III A dependent enzymes in humans. Int J Clin Pharmacol Ther Toxicol 29: 441-445
18. Joellenbeck L, Qian Z, Zarba A, Groopman JD (1992) Urinary 6β-hydroxycortisol cortisol ratios measured by high-performance liquid chromatography for use as a biomarker for the human cytochrome P-450 3A4. Cancer Epidemiol Biomarkers Prev 1: 567-572
19. Nakamura J, Yakata M (1985) Age- and sex-related difference in urinary excretion of 6β-hydroxycortisol in humans. Clin Chimica Acta 152: 193-197
20. Vauzelle-Kervoedan F, Rey E, Pariente-Khayat A, Bienvenu T, Badoual J, Olive G, Pons G (1996) Non invasive in vivo study of the maturation of CYP III A in neonates and infants. Eur J Clin Pharmacol 51: 69-72
21. Hakkola J, Pasanen M, Purkunen R, Saarikoski S, Pelkonen O, Maenpaa J, Rane A, Raunio H (1994) Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver. Biochem Pharmacol 48: 59-64