Human D2 and D4 dopamine receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: Selective antagonism by L-741,626 and L-745,870 respectively

Neuropharmacology

Volumn 37, Issue 8, 1998, Pages 983-987

  Pillai, Gopalan ^a   Brown, Nicola A ^a   McAllister, George ^a   Milligan, Graeme ^b   Seabrook, Guy R ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

D2 dopamine receptors; D4 dopamine receptors; G protein activated K channels (GIRK1 Kir3.1); G proteins

Indexed keywords

3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; L 741626; LIGAND; POTASSIUM CHANNEL; QUINPIROLE; SULPIRIDE; UNCLASSIFIED DRUG; 3 ((4 (4 CHLOROPHENYL)PIPERAZIN 1 YL)METHYL) 1H PYRROLO(2,3 B)PYRIDINE; 3-((4-(4-CHLOROPHENYL)PIPERAZIN-1-YL)METHYL)-1H-PYRROLO(2,3-B)PYRIDINE; DRD4 PROTEIN, HUMAN; INDOLE DERIVATIVE; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS; CELL MEMBRANE POTENTIAL; CHANNEL GATING; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; PATCH CLAMP; PHYSIOLOGY;

DOPAMINE ANTAGONISTS; GTP-BINDING PROTEINS; HUMANS; INDOLES; ION CHANNEL GATING; MEMBRANE POTENTIALS; OOCYTES; PATCH-CLAMP TECHNIQUES; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; PYRIDINES; PYRROLES; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4;

EID: 0031593409     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00092-6     Document Type: Article

References (16)

1. Bowery, B.J., Rothwell, L.A., Seabrook, G.R., 1994. Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area. Br. J. Pharmacol. 112, 873-880.
2. 2 receptor antagonist L-741,626. Br. J. Pharmacol. 119, 1491-1497.
3. 4 receptor antagonist. Trends Pharmacol. Sci. 18, 186-188.
4. 1 receptors. Br. J. Pharmacol. 116, 2346-2348.
5. + channel: expression cloning and molecular properties. Proc. Natl. Acad. Sci. USA 90, 10235-10239.
6. ACh currents in oocytes. Neuron 16, 423-429.
7. + channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain. Biochem. Biophys. Res. Commun. 208 (3), 1166-1173.
8. + -channel proteins. Nature 374, 135-141.
9. Kubo, Y., Reuveney, E., Slesinger, P.A., Jan, Y.N., Jan, L.Y., 1993. Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature 364, 802-806.
10. 4 receptor. J. Med. Chem. 39 (10), 1941-1942.
11. 2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta. J. Physiol. 392, 397-416.
12. 4 receptor. J. Pharmacol. Exp. Ther. 283, 636-647.
13. Reuveny, E., Slesinger, P.A., Inglese, J., Morales, J.M., Iniguez-Liuhi, J.A., Lefkowitz, R.J., Bourne, H.R., Jan, Y.N., Jan, L.Y., 1994. Activation of the cloned muscarinic potassium channel by G-protein βγ subunits. Nature 370, 143-146.
14. + channel critical for activation by G protein βγ subunits. Neuron 13, 747-755.
15. + channel. FEBS Lett. 379, 31-37.
16. 4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes. Mol. Pharmacol. 49, 656-661.