Age-related decline in humoral immunity caused by the selective loss of T(H) cells and decline in cellular immunity caused by the impaired migration of inflammatory cells without a loss of T(DTH) cells in SAMP1 mice

Mechanisms of Ageing and Development

Volumn 99, Issue 3, 1997, Pages 199-217

  Toichi, Eiko ^a   Hanada, Keigo ^a   Hosokawa, Tomohide ^b   Higuchi, Keiichi ^a   Hosokawa, Masanori ^a   Imamura, Sadao ^a   Hosono, Masamichi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY OF EDUCATION   (Japan)

Author keywords

Aging; Antibody response; Delayed type hypersensitivity; Senescence accelerated mouse; T cell

Indexed keywords

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CELL MIGRATION; CELLULAR IMMUNITY; DELAYED HYPERSENSITIVITY; EFFECTOR CELL; FOOT PAD; HELPER CELL; HUMORAL IMMUNITY; INFLAMMATORY CELL; INVOLUTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; SHEEP ERYTHROCYTE; SPLEEN; SPLEEN CELL; THYMUS;

AGING; ANIMALS; ANTIBODIES; ANTIBODY FORMATION; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MOVEMENT; HYPERSENSITIVITY, DELAYED; IMMUNITY, CELLULAR; INFLAMMATION; LYMPHOCYTE COUNT; MICE; ORGAN SIZE; SHEEP; T-LYMPHOCYTES, HELPER-INDUCER; THYMUS GLAND;

ANIMALIA; OVIS ARIES;

EID: 0031592365     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(97)00100-0     Document Type: Article

References (35)

1. Abbas A.K., Murphy K.M., Sher A. Functional diversity of helper T lymphocytes. Nature. 383:1996;787-793.
2. Austyn J.M., Gordon S. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur. J. Immunol. 11:1981;805-815.
3. Boersma W.J., Steinmeier F.A., Haaijman J.J. Age-related changes in the relative numbers of Thy-1- and Lyt-2-bearing peripheral blood lymphocytes in mice: a longitudinal approach. Cell. Immunol. 93:1985;417-430.
4. Cher D.J., Mosmann T.R. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. J. Immunol. 138:1987;3688-3694.
5. Covelli V., Mouton D., Di M.V., Bouthillier Y., Bangrazi C., Mevel J.C., Rebessi S., Doria G., Biozzi G. Inheritance of immune responsiveness, life span and disease incidence in interline crosses of mice selected for high or low multispecific antibody production. J. Immunol. 142:1989;1224-1234.
6. Cunningham A.J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 14:1968;599-600.
7. Hahn H., Kaufmann S.H., Falkenberg F., Chahinin M., Horn W. Peritoneal exudate T lymphocytes with specificity to sheep red blood cells. II. Inflammatory helper T cells and effector T cells in mice with delayed-type hypersensitivity and in suppressed mice. Immunology. 38:1979;51-55.
8. Hanada K., Hosono M., Hosokawa T., Chen W.E., Tsuboyama T., Takeda T. Immune responses in newly developed short-lived SAM mice. III. Genetic control of defective helper T cell activity in in vitro primary antibody response. Immunology. 68:1989;540-546.
9. Hanada K., Katoh H., Hosokawa T., Hosono M., Takeda T. Immune responses in newly developed short-lived SAM mice. IV. Chromosomal location of a gene controlling defective helper T cell activity. Immunology. 74:1991;160-164.
10. Haruna H., Inaba M., Inaba K., Taketani S., Sugiura K., Fukuba Y., Doi H., Toki J., Tokunaga R., Ikehara S. Abnormalities of B cells and dendritic cells in SAMP1 mice. Eur. J. Immunol. 25:1995;1319-1325.
11. Higuchi K., Matsumura A., Honma A., Takeshita S., Hashimoto K., Hosokawa M., Yasuhira K., Takeda T. Systemic senile amyloid in senescence-accelerated mice. A unique fibril protein demonstrated in tissues from various organs by the unlabeled immunoperoxidase method. Lab. Invest. 48:1983;231-240.
12. Hosokawa T., Hosono M., Higuchi K., Aoike A., Kawai K., Takeda T. Immune responses in newly developed short-lived SAM mice. I. Age-associated early decline in immune activities of cultured spleen cells. Immunology. 62:1987;419-423.
13. Hosokawa T., Hosono M., Hanada K., Aoike A., Kawai K., Takeda T. Immune responses in newly developed short-lived SAM mice. Selectively impaired T-helper cell activity in in vitro antibody response. Immunology. 62:1987;425-429.
14. Hurtrel B., Maire M.A., Hurtrel M., Lagrange P.H. Different time course patterns of local expression of delayed-type hypersensitivity to sheep red blood cells in mice. Cell. Immunol. 142:1992;252-263.
15. Julius M.H., Simpson E., Herzenberg L.A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 3:1973;645-649.
16. Kubo M., Cinader B. Polymorphism of age-related changes in interleukin (IL) production: differential changes of T-helper subpopulations, synthesizing IL 2, IL 3 and IL 4. Eur. J. Immunol. 20:1990;1289-1296.
17. Kudo C., Yamashita T., Terashita M., Sendo F. Modulation of in vivo immune response by selective depletion of neutrophils using a monoclonal antibody, RP-3. II. Inhibition by RP-3 treatment of mononuclear leukocyte recruitment in delayed-type hypersensitivity to sheep red blood cells in rats. J. Immunol. 150:1993;3739-3746.
18. Mackaness G.B., Lagrange P.H., Miller T.E., Ishibashi T. Feedback inhibition of specifically sensitized lymphocytes. J. Exp. Med. 139:1974;543-559.
19. Matsushita M., Tsuboyama T., Kasai R., Okumura H., Yamamuro T., Higuchi K., Higuchi K., Kohno A., Yonezu T., Utani A., Umezawa M., Takeda T. Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis. Am. J. Pathol. 125:1986;276-283.
20. Mayadas T.N., Johnson R.C., Rayburn H., Hynes R.O., Wagner D.D. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell. 74:1993;541-554.
21. Miller R.A. The aging immune system: primer and prospectus. Science. 273:1996;70-74.
22. Mitsuoka A., Teramatsu T., Baba M., Morikawa S., Yasuhira K. Delayed hypersensitivity in mice induced by intravenous sensitization with sheep erythrocytes: evidence for tuberculin type delayed hypersensitivity of the reaction. Immunology. 34:1978;363-370.
23. Miyamoto M., Kiyota Y., Yamazaki N., Nagaoka A., Matsuo T., Nagawa Y., Takeda T. Age-related changes in learning and memory in the senescence-accelerated mouse (SAM). Physiol. Behav. 38:1986;399-406.
24. Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., Coffman R.L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:1986;2348-2357.
25. Pawelec G. Molecular and cell biological studies of ageing and their application to considerations of T lymphocyte immunosenescence. Mech. Ageing Dev. 79:1995;1-32.
26. Roberts-Thomson I.C., Whittingham S., Youngchaiyud U., Mackay I.R. Ageing, immune response and mortality. Lancet. 2:1974;368-370.
27. Shimada A., Ohta A., Akiguchi I., Takeda T. Inbred SAM-P/10 as a mouse model of spontaneous, inherited brain atrophy. J. Neuropathol. Exp. Neurol. 51:1992;440-450.
28. Takeda T., Hosokawa M., Takeshita S., Irino M., Higuchi K., Matsushita T., Tomita Y., Yasuhira K., Hamamoto H., Shimizu K., Ishii M., Yamamuro T. A new murine model of accelerated senescence. Mech. Ageing Dev. 17:1981;183-194.
29. Takeda T., Hosokawa M., Higuchi K. Senescence-accelerated mouse (SAM): a novel murine model of accelerated senescence. J. Am. Geriatr. Soc. 39:1991;911-919.
30. Takeda T., Hosokawa M., Higuchi K., Hosono M., Akiguchi I., Katoh H. A novel murine model of aging, senescence-accelerated mouse (SAM). Arch. Gerontol. Geriatr. 19:1994;185-192.
31. Thoman M.L., Weigle W.O. Lymphokines and aging: interleukin-2 production and activity in aged animals. J. Immunol. 127:1981;2102-2106.
32. Usui T., Yoshioka H., Sung M., Ko K., Nagata N., Okamoto T., Ohshio G., Sugiyama T., Inada M., Kita T. Age associated changes in Th1-like and Th2-like helper T cells in Peyer's patches of senescence-accelerated mice (SAMP1/Kgy). Med. Sci. Res. 24:1996;229-231.
33. - cells in C57BL/Ka and CBA/Rij mice. Cell. Immunol. 108:1987;323-334.
34. + T cells underlies the impaired DTH reactivity in old mice. Mech. Ageing Dev. 53:1990;127-139.
35. Wayne S.J., Rhyne R.L., Garry P.J., Goodwin J.S. Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60. J. Gerontol. 45:1990;M45-48.