Decreased energy demanding processes in the frontal lobes of schizophrenics due to neuroleptics? A 31P-magneto-resonance spectroscopic study

Psychiatry Research - Neuroimaging

Volumn 76, Issue 2-3, 1997, Pages 123-129

  Volz, Hans Peter ^a   Rzanny, Reinhard ^a   Rößger, Grit ^a   Hübner, Gabriele ^a   Kreitschmann Andermahr, Ilonka ^a   Kaiser, Werner Alois ^a   Sauer, Heinrich ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

31Phosphorus magnetic resonance spectroscopy; Frontal lobe; Neuroleptics; Schizophrenia

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; NEUROLEPTIC AGENT; PHOSPHATE; PHOSPHORUS 31;

ADULT; ARTICLE; CONTROLLED STUDY; ENERGY; FEMALE; FRONTAL LOBE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHOSPHATE METABOLISM; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RATING SCALE; SCHIZOPHRENIA;

ADENOSINE TRIPHOSPHATE; ADULT; ANTIPSYCHOTIC AGENTS; BRIEF PSYCHIATRIC RATING SCALE; FEMALE; FRONTAL LOBE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; PHOSPHOCREATINE; PHOSPHORUS; SCHIZOPHRENIA;

EID: 0031592286     PISSN: 09254927     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4927(97)00047-4     Document Type: Article

References (21)

1. American Psychiatric Association, 1987. Diagnostic and Statistical Manual of Mental Disorders. Third revised edition. American Psychiatric Press, Washington, D.C.
2. Andreasen, N.C., 1983. The Scale for the Assessment of Negative Symptoms (SANS). The University of Iowa, Iowa City.
3. Andreasen, N.C., 1984. The Scale for the Assessment of Positive Symptoms (SAPS). The University of Iowa, Iowa City.
4. Andreasen N.C., Rezai K., Alliger R., Swayze V.W., Flaum M., Kirchner P., Cohen G., O'Leary D.S. Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Archives of General Psychiatry. 49:1992;943-958.
5. Bortz, J., Lienert, G.A., Boehnke, K., 1990. Verteilungsfreie Methoden der Biostatistik. Springer, Berlin, p. 230.
6. Cleghorn J.M., Garnett E.S., Nahmias C., Firnau G., Brown G.M., Kaplan R., Szechtman H., Szechtman B. Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia. Psychiatry Research. 28:1989;119-133.
7. Corcoran R., Frith C.D. Neuropsychology and neurophysiology in schizophrenia. Current Opinion in Psychiatry. 6:1993;74-79.
8. 99mTc-exametazime in unmedicated schizophrenic patients. Biological Psychiatry. 33:1993;487-495.
9. Erecinska M., Silver I.A. ATP and brain function. Journal of Cerebral Blood Flow and Metabolism. 9:1989;2-19.
10. Hubesch B., Sappey-Marinier D., Roth K., Meyerhoff D.J., Malson G.B., Weiner M.W. P-31 MR spectroscopy of normal human brain and brain tumors. Radiology. 174:1990;401-409.
11. Kato T., Shioiri T., Murashita J., Hamakawa H., Inubushi T., Takahashi S. Lateralized abnormality of high-energy phosphate and bilateral reduction of phosphomonoester measured by phosphorus-31 magnetic resonance spectroscopy of the frontal lobes in schizophrenia. Psychiatry Research: Neuroimaging. 61:1995;151-160.
12. National Institute of Mental Health, 1970. Clinical Global Impressions. In: Guy, W., Bonato, R.R. (Eds.), Manual for the ECDEU Assessment Battery. Chevy Chase, Maryland, pp. 12-1-12-6.
13. Overall, J.E., Gorham, D.R., 1976. BPRS: Brief Psychiatric Rating Scale. In: Guy, W. (Ed.), ECDEU Assessment Manual for Psychopharmacology. Rev. Ed. Rockville, Maryland, pp. 157-169.
14. 31P magnetic resonance spectroscopy. Journal of Cerebral Blood Flow and Metabolism. 12:1992;584-592.
15. Sauter A., Rudin M. Determination of creatine kinase parameters in rat brain by NMR magnetization transfer: correlation with brain function. Journal of Biological Chemistry. 268:1993;13166-13171.
16. Szechtman H., Nahmias C., Garnett E.S., Firnau G., Brown G.M., Kaplan R.D., Cleghorn J.M. Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Archives of General Psychiatry. 45:1988;523-532.
17. Volkow N.D., Brodie J.D., Wolf A.P., Angrist B., Russell J., Cancro R. Brain metabolism in patients with schizophrenia before and after acute neuroleptic administration. Journal of Neurology, Neurosurgery and Psychiatry. 49:1986;1199-1202.
18. 31P magnetic resonance spectroscopy in the dorsolateral prefrontal cortex of schizophrenics with a volume selective technique - preliminary findings. Biological Psychiatry. 41:1997;644-648.
19. 31P magnetic resonance spectroscopy in the dorsolateral prefrontal region of schizophrenics - a study including 50 patients and 36 controls. In Revision.
20. Wiesel F.A., Wik G., Sjögren I., Blomqvist G., Greitz T., Stone-Elander S. Regional brain glucose metabolism in drug free schizophrenic patients and clinical correlates. Acta Psychiatrica Scandinavica. 76:1987;628-641.
21. Williamson P., Drost D., Stanley J., Carr T., Morrison S., Merskey H. Localized phosphorus 31 magnetic resonance spectroscopy in chronic schizophrenic patients and normal controls. Archives of General Psychiatry (Letter). 48:1991;578.