An immunocytochemical investigation of the relationship between substance P and the neurokinin-1 receptor in the lateral horn of the rat thoracic spinal cord

Brain Research

Volumn 777, Issue 1-2, 1997, Pages 22-30

  Pollock, R ^a   Kerr, R ^a   Maxwell, D J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Confocal microscopy; Electron microscopy; Sympathetic preganglionic neuron; Synaptic transmission; Volume transmission

Indexed keywords

CHOLINE ACETYLTRANSFERASE; NEUROKININ 1 RECEPTOR; SUBSTANCE P;

ANIMAL CELL; ARTICLE; CELL LABELING; CONFOCAL MICROSCOPY; ELECTRON MICROSCOPY; FEMALE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; PREGANGLIONIC NERVE; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE; SYNAPTIC TRANSMISSION; THORACIC SPINAL CORD;

ANIMALS; AXONS; DENDRITES; FEMALE; IMMUNOHISTOCHEMISTRY; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; NEURONS; RATS; RATS, INBRED STRAINS; RECEPTORS, NEUROKININ-1; SPINAL CORD; SUBSTANCE P; SYNAPTIC TRANSMISSION;

EID: 0031589754     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00965-7     Document Type: Article

References (41)

1. [1] C.R. Anderson, S.L. Edwards, Intraperitoneal injections of Fluorogold reliably labels all sympathetic preganglionic neurons in the rat, J. Neurosci. Methods 53 (1994) 137-141.
2. [2] S.B. Backman, J.L. Henry, Effects of substance P and thyrotropin-releasing hormone on sympathetic preganglionic neurons in the upper thoracic intermediolateral nucleus of the cat, Can. J. Physiol. Pharmacol. 62 (1984) 251-284.
3. [3] S.B. Backman, H. Sequeria-Martinho, J.L. Henry, Adrenal versus non-adrenal sympathetic preganglionic neurons in the lower thoracic intermediolateral nucleus of the cat: effects of serotonin, substance P and thyrotropin-releasing hormone, Can. J. Physiol. Pharmacol. 68 (1990) 1108-1118.
4. [4] S.J. Bacon, A.D. Smith, Preganglionic sympathetic neurons innervating the rat adrenal medulla: immunocytochemical evidence of synaptic input from nerve terminals containing substance P, GABA, or 5-hydroxytryptamine, J. Auton. Nerv. Syst. 24 (1988) 97-122.
5. [5] A. Baude, Z. Nusser, J.D.B. Roberts, E. Mulvihill, R.A.J. McIlhinney, P. Somogyi, The metabotropic glutamate receptor (mGluR1α) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction, Neuron 11 (1993) 771-787.
6. 1 receptor and the actions of tachykinin agonists in the dorsal horn of the rat indicates that substance P does not have a functional role on substantia gelatinosa (lamina II) neurons, J. Neurosci. 14 (1994) 7655-7664.
7. [7] T.C. Brelje, M.W. Wessendorf, R.L. Sorenson, Multicolour laser scanning confocal immunofluorescence microscopy: practical applications and limitations, in: B. Matsumoto (Ed.), Cell Biological Applications of Confocal Microscopy, Academic Press, San Diego, 1993, pp. 97-181.
8. [8] J.L. Brown, H. Liu, J.E. Maggio, S.R. Vigna, P.W. Mantyh, A.I. Basbaum, Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis, J. Comp. Neurol. 356 (1995) 327-344.
9. [9] C. Cammack, S.D. Logan, Excitation of rat sympathetic preganglionic neurons by selective activation of the NK1 receptor, J. Auton. Nerv. Syst. 57 (1996) 87-92.
10. [10] J.H. Coote, The organisation of cardiovascular neurons in the spinal cord, Rev. Physiol. Biochem. Pharmacol. 110 (1988) 147-285.
11. [11] B.M. Davis, J.E. Krause, J.F. McKelvy, J.B. Cabot, Effects of spinal lesions on substance P levels in the rat sympathetic preganglionic cell column: evidence for local spinal regulation, Neuroscience 13 (1984) 1311-1326.
12. [12] S. De Biasi, A. Rustioni, Glutamate and substance P co-exist in primary afferent terminals in the superficial laminae of spinal cord, Proc. Natl. Acad. Sci. 85 (1988) 7820-7824.
13. [13] A.W. Duggan, I.A. Hendry, Laminar localization of the sites of release of immunoreactive substance P in the dorsal horn with antibody coated microelectrodes, Neurosci. Lett. 68 (1986) 134-140.
14. [14] A.W. Duggan, I.A. Hendry, C.R. Morton, W.D. Hutchison, Z.Q. Zhao, Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat, Brain Res. 451 (1988) 261-273.
15. [15] A.W. Duggan, H.-G. Schaible, P.J. Hope, C.W. Lang, Effect of peptidase inhibition on the pattern of intraspinally released immunoreactive substance P detected with antibody microprobes, Brain Res. 579 (1992) 261-269.
16. [16] K. Fuxe, L.F. Agnati, Two principal modes of electrochemical communication in the brain: volume versus wiring transmission, Adv. Neurosci. 1 (1991) 1-9.
17. [17] M.P. Gilbey, K.E. McKenna, L.P. Schramm, Effects of substance P on sympathetic preganglionic neurons, Neurosci. Lett. 41 (1983) 157-159.
18. [18] I. Grkovic, C.R. Anderson, Distribution of immunoreactivity for the NK1 receptor on different subpopulations of sympathetic preganglionic neurons in the rat, J. Comp. Neurol. 374 (1996) 376-386.
19. [19] C.J. Helke, J.E. Krause, P.W. Mantyh, R. Couture, M.J. Bannon, Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms, Fed. Am. Soc. Exp. Biol. 4 (1990) 1606-1615.
20. [20] C.J. Helke, L. Yang, Neuropeptides and serotonin in spinal autonomic systems, Ann. NY Acad. Sci. 780 (1996) 185-192.
21. [21] T. Honda, N. Ozaki, Y. Tonosaki, K. Nishiyama, R. Shigemoto, Y. Sugiura, Synaptic organization and ultrastructural features of the substance P-receptor-like immunoreactive neurons in the nucleus intermediolateralis of rats, Neurosci. Lett. 197 (1995) 117-120.
22. [22] T.L. Krukoff, J. Ciriello, F.R. Calerusu, Segmental distribution of peptide-and 5-HT-like immunoreactivity in nerve terminals and fibres of the thoracolumbar sympathetic nuclei of the cat, J. Comp. Neurol. 240 (1985) 103-116.
23. [23] D.I. Lewis, J.H. Coote, The influence of 5-hydroxytrypatmine agonists and antagonists on identified sympathetic preganglionic neurons, Br. J. Pharmacol. 99 (1990) 667-672.
24. [24] N.K. Littlewood, A.J. Todd, R.C. Spike, C. Watt, S.A.S. Shehab, The types of neuron in spinal dorsal horn which possess neurokinin-1 receptors, Neuroscience 66 (1995) 597-608.
25. [25] H. Liu, J.L. Brown, L. Jasmin, J.E. Maggio, S.R. Vigna, P.W. Mantyh, A.I. Basbaum, Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors, Proc. Natl. Acad. Sci. USA 91 (1994) 1009-1013.
26. [26] L.J. Llewellyn-Smith, C.L. Martin, J.B. Minson, P.M. Pilowsky, L.F. Arnolda, A.I. Basbaum, J.P. Chalmers, Neurokinin-1 receptor-immunoreactive sympathetic preganglionic neurons: target specificity and ultrastructure, Neuroscience 77 (1997) 1137-1149.
27. [27] P.W. Mantyh, E. DeMaster, A. Malhotra, J.R. Ghilardi, S.D. Rogers, C.R. Mantyh, H. Liu, A.I. Basbaum, S.R. Vigna, J.E. Maggio, D.A. Simone, Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation, Science 268 (1995) 1629-1632.
28. [28] P.W. Mantyh, S.D. Rogers, J.R. Ghilardi, J.E. Maggio, C.R. Mantyh, S.R. Vigna, Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo, Brain Res. 719 (1996) 8-13.
29. [29] D.J. McGonigle, D.J. Maxwell, S.A.S. Shehab, R. Kerr, Evidence for the presence of neurokinin-1 receptors on dorsal horn spinocerebellar tract cells in the rat, Brain Res. 742 (1996) 1-9.
30. [30] A. Merighi, J.M. Polak, D.T. Theodosis, Ultrastructural visualization of glutamate and aspartate immunoreactivities in the rat dorsal horn, with special reference to the co-localization of glutamate, substance P and calcitonin-gene related peptide, Neuroscience 40 (1991) 67-80.
31. [31] M. Naim, R.C. Spike, C. Watt, S.A.S. Shehab, A.J. Todd, Cells in laminae III and IV of the rat spinal cord which possess the neurokinin-1 receptor and have dorsally-directed dendrites receive a major synaptic input from tachykinin-containing primary afferents, J. Neurosci. 17 (1997) 5536-5548.
32. [32] Y. Nakaya, T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat, J. Comp. Neurol. 347 (1994) 249-274.
33. [33] K. Nevin, H. Zhuo, C.J. Helke, Neurokinin A coexists with substance P and serotonin in ventral medullary spinally projecting neurons of the rat, Peptides 15 (1994) 1003-1011.
34. [34] Z. Nusser, E. Mulvihill, P. Streit, P. Somogyi, Subsynaptic segregation of metabotropic and ionotropic glutamate receptors as revealed by immunogold localization, Neuroscience 61 (1994) 421-427.
35. [35] B.J. Oldfield, A. Shepard, G. Nilaver, A study of the substance P innervation of the intermediate zone of the thoracolumbar spinal cord, J. Comp. Neurol. 236 (1985) 127-140.
36. [36] P. Pilowsky, I.J. Llewellyn-Smith, J. Lipski, J. Chalmers, Substance P immunoreactive boutons form synapses with feline sympathetic preganglionic neurons, J. Comp. Neurol. 320 (1992) 121-135.
37. [37] R. Pollock, R. Kerr, D.J. Maxwell, Confocal Microscopic studies of sympathetic preganglionic neurons in the rat spinal cord, Brain Res. Assoc. Abstr. 14 (1997) 17.03.
38. [38] P.L. Vera, V.R. Holets, K.E. Miller, Ultrastructural evidence of synaptic contacts between substance P-, enkephalin-, serotonin-immunoreactive terminals and retrogradely labelled sympathetic preganglionic neurons in the rat: a study using a double peroxidase procedure, Synapse 6 (1990) 221-229.
39. [39] S.R. Vigna, J.J. Bowden, D.M. McDonald, J. Fisher, A. Okamoto, D.C. McVey, D.G. Payan, N.W. Burnett, Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells, J. Neurosci. 14 (1994) 834-835.
40. [40] M.W. Wessendorf, R. Elde, The coexistence of serotonin-and substance P-like immunoreactivity in the spinal cord of the rat as shown by immunofluorescent double labeling, J. Neurosci. 7 (1987) 2352-2363.
41. [41] K. Yashpal, T.-V. Dam, R. Quirion, Quantitative autoradiographic distribution of multiple neurokinin binding sites in rat spinal cord, Brain Res. 506 (1990) (1990) 259-266.