Reduction of ochratoxin A toxicity by heat-induced epimerization. In vitro effects of ochratoxins on embryonic chick meningeal and other cell cultures

Toxicology

Volumn 118, Issue 2-3, 1997, Pages 205-210

  Bruinink, A ^a,b   Rasonyi, T ^a   Sidler, C ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

Author keywords

Brain; Chick; Culture; Fibroblast; Ochratoxin A epimer; Ochratoxins; Retina

Indexed keywords

OCHRATOXIN;

ANIMAL CELL; ARTICLE; BRAIN; CELL CULTURE; CONTROLLED STUDY; COOKING; DOSE RESPONSE; DRUG OXIDATION; DRUG SENSITIVITY; DRUG TOXICITY; EMBRYO; FIBROBLAST; FOOD CONTAMINATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RETINA NEUROEPITHELIAL LAYER; TEMPERATURE;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CARCINOGENS; CELLS, CULTURED; CHICK EMBRYO; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FIBROBLASTS; HEAT; MENINGES; MYCOTOXINS; OCHRATOXINS; POLYMERS; RETINA; RNA, TRANSFER, PHE;

ANIMALIA;

EID: 0031588948     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(96)03615-3     Document Type: Article

References (23)

1. Baumann, U. and Zimmerli, B. (1988) Einfache ochratoxin-A - Bestimmung in Lebensmitteln. Mitt. Gebiete Lebensm. Hyg. 79, 151-158.
2. Boorman, G.A. (1989) Toxicology and carcinogenesis studies of ochratoxin A in F344/N rats. NTP Tech. Rep, No. 358.
3. Boudra, H., Le Bars, P. and Le Bars, J. (1995) Thermostability of ochratoxin A in wheat under moisture conditions, Appl. Environ. Microbiol. 61, 1156-1158.
4. Braunberg, R.C., Gantt, O., Barton, C. and Friedman, L. (1992) In vitro effects of the nephrotoxins ochratoxin A and citrinin upon biochemical function of porcine kidney. Arch. Environ. Contam. Toxicol. 22, 464-470.
5. Bruinink, A. (1992) Serum-free monolayer cultures of embryonic chick brain and retina: immunoassays of developmental markers, mathematical data analysis and establishment of optimal culture conditions. In: G. Zbinden (Ed), The Brain in Bits and Pieces, MTC Verlag, Zollikon, pp. 23-50.
6. Bruinink, A. and Reiser, P. (1991) Ontogeny of MAP2 and GFAP antigens in primary cultures of embryonic chick brain: effect of substratum, oxygen tension, serum and ARA-C. Int. J. Dev. Neurosci. 9, 269-279.
7. Bruinink, A., Müller, J., Shah-Derler, B., Sidler, C., Reiser, P., Birchler, F., Rasonyi, T. and Zimmermann, G. (1994) A serum-free neurotoxicity screening system using embryonic chick cells (SCENT). Toxicol. Lett. 74, 11.
8. Burns, R.B. and Dwivedi, P. (1986) The natural occurence of ochratoxin A and its effects in poultry. A review. Part II. Pathology and immunology. World Poult. Sci. J. 42, 48-55.
9. Chu, F.S. (1974) Studies on ochratoxins. CRC Crit. Rev. Toxicol. 2, 499-524.
10. Creppy, E.E., Kern, D., Steyn, P.S., Vleggaar, R., Röschenthaler, R. and Dirheimer, G. (1983) Comparitive study of the effects of ochratoxin A analoques on yeast phenylalanyl-tRNA synthetase and on the growth and protein synthesis of hepatoma cells. Toxicol. Lett. 19, 217-224.
11. DFG (1990). Ochratoxin A, Vorkommen und toxikologische Bewertung. Deutsche Forschungsgemeinschaft, DFG
12. Dirheimer, G. and Creppy, E.E. (1991) Mechanism of action of ochratoxin A. IARC Sci. Publ. 115, 171-186.
13. Föllmann, W., Hillebrand, I.E., Creppy, E.E. and Bolt, H.M. (1995) Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated with ochratoxin A and alpha. Arch. Toxicol. 69, 2880-286.
14. Hald, B. (1991) Ochratoxin A in human blood in European countries. IARC Sci. Publ. 115, 159-164
15. Hamburger, V. and Hamilton, H.L. (1951) A series of normal stages in the development of the chick embryo. J. Morphol. 88, 49-92.
16. Krogh P., Elling F., Hald B., Jylling B, Petersen V.E., Skadhauge E. and Svedsen C.K. (1976) Experimental avian nephropathy. Acta Path. Microbiol. Scand. 84, 215-221.
17. Miki, T., Fukui, Y., Uemura, N. and Takeuchi, Y. (1994) Regional difference in the neurotoxicity of ochratoxin A on the developing cerebral cortex in mice. Dev. Brain Res. 82, 259-264.
18. Peckham, J.C., Doupnik, B. and Jones, O.H. (1971) Acute toxicity of ochratoxins A and B in chicks. Appl. Microbiol. 21, 492-494.
19. Potter, R.G., Marquardt, R.R. and Frohlich, A.A. (1989) Ochratoxin A toxicity in growing chicks: effects of supplemental dietary phenylalnine. Nutr. Rep. Int. 40, 1091-1100.
20. Rásonyi, T., Schmid, P., Rásonyi, S. and Schlatter, Ch. (1997) Preparation and structural characterization of the 3S-epimer of ochratoxin A. Toxicol, Appl. Pharmacol. (in preparation).
21. Studer-Rohr, I., Schlatter, J., Dietrich, D.R. and Schlatter, Ch. (1997). Intraindividual variation in plasma levels and kinetic parameters of ochratoxin A in humans. Arch. Toxicol. (in press).
22. Tamaru, M., Hirata, Y. and Matsutani, T. (1988) Neurochemical effects of prenatal treatment with ochratoxin A on fetal and adult mouse brain. Neurochem. Res. 13, 1139-1147.
23. Terse, P.S., Madhyastha, M.S., Zurovac, O., Stringfellow, D., Marquardt, R.R., and Kemppainen, B.W. (1993). Comparison of in vitro and in vivo biological activity of mycotoxins. Toxicon 31, 913-919.