Cystosine-rich strands of the insulin minisatellite adopt hairpins with intercalated cytosine+·cytosine pairs

Journal of Molecular Biology

Volumn 272, Issue 3, 1997, Pages 369-382

  Catasti, Paolo ^c   Chen, Xian ^c   Deaven, Larry L ^a   Moyzis, Robert K ^a   Bradbury, E Morton ^b   Gupta, Goutam ^c  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE

Author keywords

Hairpin i motif; Insulin minisatellite; NMR spectroscopy; Slippage length polymorphism

Indexed keywords

CYTOSINE; DIMER; DNA MINISATELLITE; INSULIN;

ARTICLE; DNA REPLICATION; DNA SEQUENCE; DNA STRUCTURE; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL;

EID: 0031587299     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1248     Document Type: Article

References (30)

1. Ahmed S., Kintanar A., Henderson E. Human telomeric C-strand tetraplexes. Struct. Biol. 1(2):1994;83-88.
2. ntracts. Proc. Natl Acad. Sci. USA. 88:1991;507-511.
3. Bell G. I., Karam J. H., Rutter W. J. Polymorphic DNA region adjacent to the 5′ end of the human insulin gene. Proc. Natl Acad. Sci. USA. 78(9):1981;5759-5763.
4. Bell G. I., Selby M. J., Rutter W. J. The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences. Nature. 295:1982;31-35.
5. Bennett S. T., Lucassen A. M., Gough S. C. L., Powell E. E., Undlien D. E., Pritchard L. E., Merriman M. E., Kawaguchi Y., Dronsfield M. J., Pociot F., Nerup J., Bouzekri N., Cambon-Thomsen A., Rønningen K. S., Barnett A. H., Bain S. C., Todd J. A. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nature Genet. 9:1995;284-292.
6. Berger I., Kang C., Fredian A., Ratliff R., Moyzis R. K., Rich A. Extension of the four-stranded intercalated cytosine motif by adenine·adenine base pairing in the crystal structure of d(CCCAAT). Nature Struct. Biol. 2(5):1995;416-425.
7. Catasti P., Gupta G., Garcia A. E., Ratliff R., Hong L., Yau P., Moyzis R. K., Bradbury E. M. Unusual structures of the tandem repetitive DNA sequences located at human centromeres. Biochemistry. 33(13):1994;3819-3830.
8. Catasti P., Chen X., Moyzis R. K., Bradbury E. M., Gupta G. Structure-function correlations of the insulin-linked polymorphic region. J. Mol. Biol. 264(3):1996;534-545.
9. 4). Biochemistry. 33:1994;13540-13546.
10. Durland R. H., Kessler D. J., Gunnell S., Duvic M., Pettitt B. M., Hogan M. E. Binding of triple helix forming oligonucleotides to sites in gene promoters. Biochemistry. 30:1991;9246-9255.
11. Felsenfeld G. Chromatin structure and the expression of the globin-encoding genes. Gene. 135(1-2):1993;119-124.
12. Gehring K., Leroy J.-L., Gueron M. a tetrameric DNA structure with protonated cytosine-cytosine base pairs. Nature. 363:1993;561-565.
13. 34sequence from a Xenopus globin gene. J. Mol. Biol. 185:1985;461-478.
14. Gupta G., Garcia A. E., Hiriyanna K. T. Sampling of the conformations of the d(CGCTGCGGC) hairpin in solution by two-dimensional nuclear magnetic resonance and theoretical methods. Biochemistry. 32(3):1993;948-960.
15. Hammond-Kosack M. C., Dobrinski B., Lurz R., Docherty K., Kilpatrick M. W. The human insulin gene linked polymorphic region exhibits an altered DNA structure. Nucl. Acids Res. 20(2):1992;231-236.
16. ntriplet repeats from human hereditary diseases. Proc. Natl Acad. Sci. USA. 92:1995;11019-11023.
17. Kang C., Berger I., Lockshin C., Ratliff R., Moyzis R. K., Rich A. Stable loop in the crystal structure of the intercalated four-stranded cytosine-rich metazoan telomere. Proc. Natl Acad. Sci. USA. 92(9):1995;3874-3878.
18. Kennedy G. C., German M. S., Rutter W. J. the minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nature Genet. 9(3):1995;293-298.
19. ntracts arrest single stranded DNA replication in vitro. Nucl. Acids. Res. 17:1989;883-900.
20. Leroy J.-L., Gueron M. Solution structures of the i-motif tetramers of d(TCC), d(5methylCCT) and d(T5methylCC): novel NOE connections between amino protons and sugar protons. Structure. 3:1995;101-120.
21. Leroy J.-L., Gueron M., Mergny J. L., Helene C. Intramolecular folding of a fragment of the cytosine-rich strand of telomeric DNA into an i-motif. Nucl. Acids Res. 22(9):1994;1600-1606.
22. Lucassen A. M., Screaton G. R., Julier C., Elliot T. J., Lathrop M., Bell J. I. Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype. Human Mol. Genet. 4(4):1995;501-506.
23. Maxam A. M., Gilbert W. A new method for sequencing DNA. Biotechnology. 24:1992;99-103.
24. Mirkin S. M., Lyamichev V. I., Drushlyak K. N., Filippov S. A., Frank-Kamenetskii M. D. DNA H form requires a homopurine-homopyrimidine mirror repeat. Nature. 330:1987;495-497.
25. Owerbach D., Aagaard L. analysis of a 1963-bp polymorphic region flanking the human insulin gene. Gene. 32(3):1984;475-479.
26. Pearlman, D. A. Case, D. A. Caldwell, J. C. Seibel, G. L. Chandra Singh, U. Weiner, P. Kollman, P. 1991, AMBER 4.0, University of California, San Francisco.
27. Piotto M., Saudek V., Sklenar V. Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. J. Biomol. NMR. 2(6):1992;661-665.
28. Rohozinsky J., Hancock J. M., Keniry M. A. Polycytosine regions contained in DNA hairpin loops interact via a four-stranded, parallel structure similar to the i-motif. Nucl. Acids Res. 22(22):1994;4653-4659.
29. 15HSQC experiments optimized to retain full sensitivity. J. Magn. Res. ser. A. 102(2):1993;241-245.
30. Weiner S. J., Kollman P., Nguyen D. T., Case D. A. An all atom force field for simulations of proteins and nucleotide acids. J. Comp. Chem. 7(2):1986;230-252.