Neutrophil-mediated activation of mitoxantrone to metabolites which form adducts with DNA

Cancer Letters

Volumn 113, Issue 1-2, 1997, Pages 173-178

  Panousis, Con ^a   Kettle, Anthony J ^b   Phillips, Don R ^a  

^a LA TROBE UNIVERSITY   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

DNA; Mitoxantrone; Myeloperoxidase; Neutrophil

Indexed keywords

DNA; DRUG METABOLITE; DRUG METABOLIZING ENZYME; MITOXANTRONE; MYELOPEROXIDASE; PHORBOL ESTER; SODIUM AZIDE;

ARTICLE; CONTROLLED STUDY; COVALENT BOND; DNA ADDUCT; DRUG ACTIVATION; DRUG DNA BINDING; DRUG METABOLISM; DRUG OXIDATION; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; AZIDES; CARCINOGENS; CATTLE; DNA; DNA ADDUCTS; ENZYME INHIBITORS; HUMANS; MITOXANTRONE; NEUTROPHIL ACTIVATION; RESPIRATORY BURST; SODIUM AZIDE; TETRADECANOYLPHORBOL ACETATE;

EID: 0031586756     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(97)04611-9     Document Type: Article

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