Molecular properties of complexes formed between the prion protein and synthetic peptides

Journal of Molecular Biology

Volumn 270, Issue 4, 1997, Pages 574-586

  Kaneko, Kiyotoshi ^a   Wille, Holger ^a   Mehlhorn, Ingrid ^a   Zhang, Hong ^a   Ball, Haydn ^a   Cohen, Fred E ^a   Baldwin, Michael A ^a   Prusiner, Stanley B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Folding intermediate; Insolubility; Prion protein synthetic peptide; Scrapie; pleated sheet

Indexed keywords

BUFFER; GUANIDINE; PHOSPHATE; PRION PROTEIN; PROTEINASE; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; UREA;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CENTRIFUGATION; CHO CELL; CONTROLLED STUDY; ESCHERICHIA COLI; HYDROPHOBICITY; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; SYRIAN HAMSTER;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; ESCHERICHIA COLI; MESOCRICETUS AURATUS;

EID: 0031586212     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1135     Document Type: Article

References (56)

1. Bateman D., Hilton D., Love S., Zeidler M., Beck J., Collinge J. Sporadic Creutzfeldt-Jakob disease in a 18-year-old in the UK (Letter). Lancet. 346:1995;1155-1156.
2. Bessen R. A., Marsh R. F. Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent. J. Virol. 66:1992;2096-2101.
3. Bessen R. A., Kocisko D. A., Raymond G. J., Nandan S., Lansbury P. T., Caughey B. Non- genetic propagation of strain-specific properties of scrapie prion protein. Nature. 375:1995;698-700.
4. Borchelt D. R., Scott M., Taraboulos A., Stahl N., Prusiner S. B. Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. J. Cell Biol. 110:1990;743-752.
5. Borchelt D. R., Taraboulos A., Prusiner S. B. Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J. Biol. Chem. 267:1992;16188-16199.
6. Britton T. C., Al-Sarraj S., Shaw C., Campbell T., Collinge J. Sporadic Creutzfeldt-Jakob disease in a 16-year-old in the UK (Lett.). Lancet. 346:1995;1155.
7. Carlson G. A., Kingsbury D. T., Goodman P. A., Coleman S., Marshall S. T., DeArmond S. J., Westaway D., Prusiner S. B. Linkage of prion protein and scrapie incubation time genes. Cell. 46:1986;503-511.
8. Caughey B. W., Dong A., Bhat K. S., Ernst D., Hayes S. F., Caughey W. S. Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy. Biochemistry. 30:1991;7672-7680.
9. Chazot G., Broussolle E., Lapras C. I., Blättler T., Aguzzi A., Kopp N. New variant of Creutzfeldt-Jakob disease in a 26-year-old French man. Lancet. 347:1996;1181.
10. Cohen F. E., Pan K.-M., Huang Z., Baldwin M., Fletterick R. J., Prusiner S. B. Structural clues to prion replication. Science. 264:1994;530-531.
11. Egan R. W., Jones M. A., Lehninger A. L. Hydrophile-lipophile balance and critical micelle concentration as key factors influencing surfactant disruption of mitochondrial membranes. J. Biol. Chem. 251:1976;4442-4447.
12. Eigen M. Prionics or the kinetic basis of prion diseases. Biophys. Chem. 63:1996;A11-A18.
13. Gajdusek D. C. Unconventional viruses and the origin and disappearance of kuru. Science. 197:1977;943-960.
14. Gasset M., Baldwin M. A., Lloyd D., Gabriel J.-M., Holtzman D. M., Cohen F., Fletterick R., Prusiner S. B. Predicted α- helical regions of the prion protein when synthesized as peptides form amyloid. Proc. Natl Acad. Sci. USA. 89:1992;10940-10944.
15. Gasset M., Baldwin M. A., Fletterick R. J., Prusiner S. B. Perturbation of the secondary structure of the scrapie prion protein under conditions associated with changes in infectivity. Proc. Natl Acad. Sci. USA. 90:1993;1-5.
16. Glenner G. G., Eanes E. D., Page D. L. The relation of the properties of Congo red-stained amyloid fibrils to the beta-conformation. J. Histochem. Cytochem. 20:1972;821-826.
17. Hsiao K., Baker H. F., Crow T. J., Poulter M., Owen F., Terwilliger J. D., Westaway D., Ott J., Prusiner S. B. Linkage of a prion pro tein missense variant to Gerstmann-Sträussler syndrome. Nature. 338:1989;342-345.
18. Hsiao K. K., Scott M., Foster D., Groth D. F., DeArmond S. J., Prusiner S. B. Spontaneous neurodegeneration in transgenic mice with mutant prion protein. Science. 250:1990;1587-1590.
19. Hsiao K. K., Groth D., Scott M., Yang S.-L., Serban H., Rapp D., Foster D., Torchia M., DeArmond S. J., Prusiner S. B. Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein. Proc. Natl Acad. Sci. USA. 91:1994;9126-9130.
20. Huang Z., Gabriel J.-M., Baldwin M. A., Fletterick R. J., Prusiner S. B., Cohen F. E. Proposed three-dimensional structure for the cellular prion protein. Proc. Natl Acad. Sci. USA. 91:1994;7139-7143.
21. Jarrett J. T., Lansbury P. T. Jr. Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell. 73:1993;1055-1058.
22. Kaneko K., Peretz D., Pan K.-M., Blochberger T., Wille H., Gabizon R., Griffith O. H., Cohen F. E., Baldwin M. A., Prusiner S. B. Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform. Proc. Natl Acad. Sci. USA. 32:1995;11160-11164.
23. Kascsak R. J., Rubenstein R., Merz P. A., Tonna-DeMasi M., Fersko R., Carp R. I., Wisniewski H. M., Diringer H. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J. Virol. 61:1987;3688-3693.
24. Kocisko D. A., Come J. H., Priola S. A., Chesebro B., Raymond G. J., Lansbury P. T. Jr, Caughey B. Cell-free formation of protease-resistant prion protein. Nature. 370:1994;471-474.
25. Kocisko D. A., Priola S. A., Raymond G. J., Chesebro B., Lansbury P. T. Jr, Caughey B. Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier. Proc. Natl Acad. Sci. USA. 92:1995;3923-3927.
26. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T-4. Nature. 227:1970;680-685.
27. Marsh R. F., Kimberlin R. H. Comparison of scrapie and transmissible mink encephalopathy in hamsters. II. Clinical signs, pathology and pathogenesis. J. Infect. Dis. 131:1975;104-110.
28. Masters C. L., Gajdusek D. C., Gibbs C. J. Jr. Creutzfeldt-Jakob disease virus isolations from the Gerstmann-Sträussler syndrome. Brain. 104:1981;559-588.
29. Medori R., Tritschler H.-J., LeBlanc A., Villare F., Manetto V., Chen H. Y., Xue R., Leal S., Montagna P., Cortelli P., Tinuper P., Avoni P., Mochi M., Baruzzi A., Hauw J. J., Ott J., Lugaresi E., Autilio-Gambetti L., Gambetti P. Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene. N. Engl. J. Med. 326:1992;444-449.
30. Mehlhorn I., Groth D., Stöckel J., Moffat B., Reilly D., Yansura D., Willett W. S., Baldwin M., Fletterick R., Cohen F. E., Vandlen R., Henner D., Prusiner S. B. High-level expression and characterization of a purified 142-residue polypeptide of the prion protein. Biochemistry. 35:1996;5528-5537.
31. Nguyen J., Baldwin M. A., Cohen F. E., Prusiner S. B. Prion protein peptides induce α-helix to β-sheet conformational transitions. Biochemistry. 34:1995;4186-4192.
32. Pan K.-M., Baldwin M., Nguyen J., Gasset M., Serban A., Groth D., Mehlhorn I., Huang Z., Fletterick R. J., Cohen F. E., Prusiner S. B. Conversion of α-helices into β-sheets features in the formation of the scrapie prion proteins. Proc. Natl Acad. Sci. USA. 90:1993;10962-10966.
33. Parry H. B. Scrapie Disease in Sheep. 1983;Academic Press, New York.
34. Prusiner S. B. Molecular biology of prion diseases. Science. 252:1991;1515-1522.
35. Prusiner S. B., Bolton D. C., Groth D. F., Bowman K. A., Cochran S. P., McKinley M. P. Further purification and characterization of scrapie prions. Biochemistry. 21:1982a;6942-6950.
36. Prusiner S. B., Cochran S. P., Groth D. F., Downey D. E., Bowman K. A., Martinez H. M. Measurement of the scrapie agent using an incubation time interval assay. Ann. Neurol. 11:1982b;353-358.
37. Prusiner S. B., McKinley M. P., Bowman K. A., Bolton D. C., Bendheim P. E., Groth D. F., Glenner G. G. Scrapie prions aggregate to form amyloid-like birefringent rods. Cell. 35:1983;349-358.
38. Prusiner S. B., Scott M., Foster D., Pan K.-M., Groth D., Mirenda C., Torchia M., Yang S.-L., Serban D., Carlson G. A., Hoppe P. C., Westaway D., DeArmond S. J. Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication. Cell. 63:1990;673-686.
39. Raeber A. J., Borchelt D. R., Scott M., Prusiner S. B. Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems. J. Virol. 66:1992;6155-6163.
40. Riesner D., Kellings K., Post K., Wille H., Serban H., Groth D., Baldwin M. A., Prusiner S. B. Disruption of prion rods generates 10-nm spherical particles having high α-helical content and lacking scrapie infectivity. J. Virol. 70:1996;1714-1722.
41. Rogers M., Serban D., Gyuris T., Scott M., Torchia T., Prusiner S. B. Epitope mapping of the Syrian hamster prion protein utilizing chimeric and mutant genes in a vaccinia virus expression system. J. Immunol. 147:1991;3568-3574.
42. Safar J., Roller P. P., Gajdusek D. C., Gibbs C. J. Jr. Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein. J. Biol. Chem. 268:1993a;20276-20284.
43. Safar J., Roller P. P., Gajdusek D. C., Gibbs C. J. J. Thermal-stability and conformational transitions of scrapie amyloid (prion) protein correlate with infectivity. Protein Sci. 2:1993b;2206-2216.
44. Scott M., Groth D., Foster D., Torchia M., Yang S.-L., DeArmond S. J., Prusiner S. B. Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes. Cell. 73:1993;979-988.
45. Stahl N., Baldwin M. A., Teplow D. B., Hood L., Gibson B. W., Burlingame A. L., Prusiner S. B. Structural analysis of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry. 32:1993;1991-2002.
46. Taraboulos A., Scott M., Semenov A., Avrahami D., Laszlo L., Prusiner S. B. Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J. Cell Biol. 129:1995;121-132.
47. Tateishi J., Kitamoto T. Inherited prion diseases and transmission to rodents. Brain Pathol. 5:1995;53-59.
48. Telling G. C., Scott M., Mastrianni J., Gabizon R., Torchia M., Cohen F. E., DeArmond S. J., Prusiner S. B. Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein. Cell. 83:1995;79-90.
49. Telling G. C., Haga T., Torchia M., Tremblay P., DeArmond S. J., Prusiner S. B. Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice. Genes Dev. 10:1996a;1736-1750.
50. Telling G. C., Parchi P., DeArmond S. J., Cortelli P., Montagna P., Gabizon R., Mastrianni J., Lugaresi E., Gambetti P., Prusiner S. B. Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity. Science. 274:1996b;2079-2082.
51. Turk E., Teplow D. B., Hood L. E., Prusiner S. B. Purification and properties of the cellular and scrapie hamster prion proteins. Eur. J. Biochem. 176:1988;21-30.
52. Wells G. A. H., Wilesmith J. W. The neuropathology and epidemiology of bovine spongiform encephalopathy. Brain Pathol. 5:1995;91-103.
53. Will R. G., Ironside J. W., Zeidler M., Cousens S. N., Estibeiro K., Alperovitch A., Poser S., Pocchiari M., Hofman A., Smith P. G. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet. 347:1996;921-925.
54. Williamson R. A., Peretz D., Smorodinsky N., Bastidas R., Serban H., Mehlhorn I., DeArmond S. J., Prusiner S. B., Burton D. R. Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein. Proc. Natl Acad. Sci. USA. 93:1996;7279-7282.
55. Zhang H., Kaneko K., Nguyen J. T., Livshits T. L., Baldwin M. A., Cohen F. E., James T. L., Prusiner S. B. Conformational transitions in peptides containing two putative α-helices of the prion protein. J. Mol. Biol. 250:1995;514-526.
56. Zhang H., Stöckel J., Mehlhorn I., Groth D., Baldwin M. A., Prusiner S. B., James T. L., Cohen F. E. Physical studies of conformational plasticity in a recombinant prion protein. Biochemistry. 36:1997;3543-3553.