Cobalt assisted cleavage of S-S bonds and a base-free synthesis of mercapturic acids

Tetrahedron Letters

Volumn 38, Issue 12, 1997, Pages 2149-2152

  Chowdhury, Shantanu ^a   Roy, Sujit ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE DERIVATIVE; COBALT;

ARTICLE; CATALYSIS; DISULFIDE BOND; DRUG SYNTHESIS; OXIDATION; REACTION ANALYSIS;

EID: 0031585051     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00268-2     Document Type: Article

References (30)

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23. 2Br.
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30. 2S was bubbled through the solution whence a black precipitate was obtained. This precipitate was filtered, filtrate saturated with sodiumchloride and extracted with ethylacetate at 50°C. The organic layer was dried with magnesium sulfate, concentrated and the residue purified by column chromatography [silica-gel 60-120, eluent: benzene:methanol: aceticacid - 7:2:1] to obtain the desired mercapturic acid. For benzoyl chloride reaction was worked up after 4 hrs.