A novel synthesis of tert-leucine via a Leuckart type reaction

Tetrahedron Letters

Volumn 38, Issue 12, 1997, Pages 2153-2154

  Adger, Brian M ^a   Dyer, Ulrich C ^a   Lennon, Ian C ^a   Tiffin, Peter D ^a   Ward, Simon E ^a  

^a Chiroscience Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE;

ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; RACEMIC MIXTURE; STEREOISOMERISM;

EID: 0031585050     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00269-4     Document Type: Article

References (7)

1. 1. Turner, N.J.; Winterman, J.R.; McCague, R.; Parratt, J.S. and Taylor, S.J,C. Tetrahedron Lett., 1995, 36, 1113.
2. 2. Knoop, F. and Landmann, G. Z. Phsiol. Chem., 1914, 89, 157.
3. 3. The chemisty and uses of tert-leucine has recently been reviewed; Bommarius, A.S.; Schwarm, M.; Stingl, K.; Kottenhahn, M.; Huthmacher, K. and Drauz, K. Tetrahedron: Asymmetry, 1995, 6, 2851.
4. 4. Moore, M. L. Org. Reactions, 1949, 5, 301.
5. 5. Cooper, A.J.L.; Ginos, J.Z. and Meister, A. Chem Rev. 1983, 83, 321.
6. 6. Shive, W. and Shive, G.W. J. Am. Chem. Soc., 1946, 68, 117.
7. 7. CP Cyctodextrin B, 120°C for 50 min. on methyl ester derivative; retention times (S)-isomer 44.4 min. and (R)-isomer 45.1 min.