Preparation of nitriles from primary amides under Swern oxidation conditions

Tetrahedron Letters

Volumn 38, Issue 12, 1997, Pages 2099-2102

  Nakajima, Noriyuki ^a   Ubukata, Makoto ^a  

^a TOYAMA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; NITRILE;

ARTICLE; CHEMICAL REACTION; DEHYDRATION; DRUG SYNTHESIS; OXIDATION; REACTION ANALYSIS;

EID: 0031585047     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00316-X     Document Type: Article

References (26)

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2. 1. Sandler, S. R.; Karo, W.; Nitriles (Cyanides). In Organic Functioned Group Preparations; H. H. Wasserman Eds.; Academic Press, Inc.: San Diego, 1983; Vol. 12-I of Organic Chemistry, Chapter 17.
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23. 15. We observed interesting results concerning this reaction mechanism. The anti-oxime gave nitrile in moderate yield under the same reaction conditions for amide while the syn-oxime gave no reaction product at -78°C.
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25. iPrOH, 97/3, 0.8 mL/min.).
26. 3 (240.30): C, 59.98; H, 8.39; N, 11.66. Found: C, 60.13; H, 8.45; N, 11.46.