Practical synthetic route to benzimidazole-2-carboxylate derivatives via I2-induced overall 5-endo-trig cyclization

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 10, 1997, Pages 1267-1268

  Yukawa, Hirotaka ^a   Nagatani, Takeshi ^a   Torisawa, Yasuhiro ^a   Okaichi, Yoshihiko ^a   Tada, Nobuhito ^a   Furuta, Takuya ^a   Minamikawa, Jun ichi ^a   Nishi, Takao ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0031579959     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00205-9     Document Type: Article

References (7)

1. See as recent examples for the 2-arylbenzimidazole synthesis: a) Ende, J.J.V.; Delfosse, F.; Lor, P.; Haverbeke, Y.V., Tetrahedron, 1995, 51, 5813-5818;
2. b) Patzold, F.; Zeuner, F.; Heyer, T.; Niclas, H.-J., Syn. Commun., 1992, 22, 281-288;
3. c) Yadagiri, B., Lown, J.W., ibid, 1990, 20, 955- 963;
4. d) Toja, E.; Selva, D.; Schiatti, P.J. Med. Chem., 1984, 27, 610-616.
5. See for example: Boger, D.L.; Yun, W.; Cai, H.; Han, N. Bioorg. Med. Chem. 1995, 3, 761-775.
6. Knight, D.W.; Jones, A.D., J. Chem. Soc. Chem. Commun., 1996, 915-916 and references cited therein.
7. +).