Modulation of [3H]quinpirole binding to dopaminergic receptors by adenosine A(2A) receptors

Neuroscience Letters

Volumn 239, Issue 2-3, 1997, Pages 61-64

  Lepiku, Martin ^a,b   Rinken, Ago ^a   Järv, Jaak ^a   Fuxe, Kjell ^b  

^a UNIVERSITY OF TARTU   (Estonia)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

3H Quinpirole; Adenosine A(2A) receptors; Binding kinetics; CGS 21680; Dopamine D2 receptors; Receptor isomerization; Receptor receptor interaction

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; QUINPIROLE; TRITIUM; ADENOSINE; ADENOSINE RECEPTOR; ANTIHYPERTENSIVE AGENT; DOPAMINE RECEPTOR; DRUG DERIVATIVE; PHENETHYLAMINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BINDING KINETICS; CORPUS STRIATUM; DISSOCIATION CONSTANT; DOPAMINERGIC TRANSMISSION; ISOMERISM; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; ANIMAL; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; NEOSTRIATUM; PHYSIOLOGY;

ADENOSINE; ANIMALS; ANTIHYPERTENSIVE AGENTS; NEOSTRIATUM; PHENETHYLAMINES; QUINPIROLE; RATS; RECEPTORS, DOPAMINE; RECEPTORS, PURINERGIC P1;

EID: 0031578580     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00874-4     Document Type: Article

References (14)

1. Dohlman H.G., Thorner J., Caron M.G., Lefkowitz R.J. Model systems for the study of seven-transmembrane-segment receptors. Annu. Rev. Biochem. 60:1991;653-688.
2. 2 receptors in rat striatal membranes. Proc. Natl. Acad. Sci. USA. 88:1991;7238-7241.
3. Ferré S., Fuxe K., von Euler G., Johhanson B., Fredholm B. Adenosine-dopamine interactions in the brain. Neuroscience. 51:1992;501-512.
4. 2 receptors in rat neostriatal membranes. Eur. J. Pharmacol. 244:1993;311-315.
5. 2 dopamine receptors from high- to low- affinity state for dopamine agonists, using sodium ions and guanine nucleotides. J. Neurochem. 44:1985;1925-1935.
6. Järv J., Hedlund B., Bartfai T. Isomerization of the muscarinic receptor-antagonist complex. J. Biol. Chem. 254:1979;5595-5598.
7. Lepiku M., Rinken A., Järv J., Fuxe K. Kinetic evidence for isomerization of the dopamine receptor-raclopride complex. Neurochem. Int. 28:1996;591-595.
8. 2-like dopamine receptors in rat brain. J. Pharmacol. Exp. Ther. 262:1992;929-935.
9. 3 receptors: effects of ions and guanine nucleotides. J. Pharmacol. Exp. Ther. 274:1995;790-797.
10. Rinken, A., Harro, J., Engström L. and Oreland, L., Role of fluidity of membranes on the guanyl nucleotide-dependent binding of cholecystokinin 8-S to rat brain cortical membranes, Biochem. Pharmacol., (1997) in press.
11. Schiliebs R., Bigl V. Kinetics of the interaction of dihydroalperonol with beta-adrenergic receptors in rat cerebral cortex. Gen. Physiol. Biophys. 3:1984;31-46.
12. 3H]quinpirole. Eur. J. Pharmacol. 203:1991;105-109.
13. Strickland S., Palmer G., Massey V. Determination of dissociation constants and specific rate constants of enzyme-substrate (or protein-ligand) interactions from rapid reaction kinetic data. J. Biol. Chem. 250:1975;4048-4052.
14. Zoli M., Agnati L.F., Hedlund P.B., Li X.M., Ferré S., Fuxe K. Receptor-receptor interactions an integrative mechanism in nerve cells. Mol. Neurobiol. 7:1993;293-334.