α(1D)-Adrenoceptors play little role in the positive inotropic action of phenylephrine

European Journal of Pharmacology

Volumn 321, Issue 1, 1997, Pages 39-43

  Wang, Shi Nan ^a   Fontenot, H Jerrel ^a   Kennedy, Richard H ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Adrenoceptor, subtype; Atrial muscle; BMY 7378; Contractility; Papillary muscle; Rat

Indexed keywords

8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1D ADRENERGIC RECEPTOR; NADOLOL; PHENYLEPHRINE; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HEART ATRIUM MUSCLE; HEART MUSCLE CONTRACTILITY; HEART PAPILLARY MUSCLE; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; AORTA, ABDOMINAL; CARDIOTONIC AGENTS; HEART ATRIA; ISOMETRIC CONTRACTION; MALE; MUSCLE CONTRACTION; PAPILLARY MUSCLES; PHENYLEPHRINE; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 0031577965     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00003-4     Document Type: Article

References (21)

1. 1C-adrenoceptor: studies in the isolated perfused kidney of rat, Br. J. Pharmacol. 115, 283.
2. Bylund, D.B., D.C. Eikenberg, J.P. Hieble, S.Z. Langer, R.J. Lefkowitz, K.P. Minneman, P.B. Molinoff, R.R. Ruffolo and U. Trendelenburg, 1994, International Union of Pharmacology nomenclature of adrenoceptors, Pharmacol. Rev. 46, 121.
3. 1-adrenergic receptor, Proc. Natl. Acad. Sci. USA 85, 7159.
4. Deng, X.F., S. Chemtob, G. Almazan and D.R. Varma, 1996, Ontogenic differences in the functions of myocardial alpha-1 adrenoceptor subtypes in rats, J. Pharmacol. Exp. Ther. 276, 1155.
5. 1A subtype antagonists WB 4101 and 5-methylurapidil, Naunyn-Schmiedeberg's Arch. Pharmacol. 345, 578.
6. 1-adrenoceptor subtypes in the heart ventricular muscle, J. Pharm. Pharmacol. 45, 907.
7. 1-adrenoceptors, Eur. J. Pharmacol. 272, R5.
8. 1-Adrenergic receptor subtypes, molecular structure, function, and signaling, Circ. Res. 78, 737.
9. 1-adrenoceptors: consensus update, Pharmacol. Rev. 47, 267.
10. 1-adrenergic agonists in adult rat heart, Am. J. Physiol. 267, H970.
11. Lefkowitz, R.J. and M.G. Caron, 1990, The adrenergic receptors, in: The Biology and Medicine of Signal Transduction, eds. Y. Nishizuka, M. Endoh and C. Tanaka (Raven Press, New York, NY) p. 1.
12. 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle, Br. J. Pharmacol. 111, 539.
13. 1D-adrenergic receptor cDNA, Mol. Pharmacol. 40, 876.
14. 1A subtype, Mol. Pharmacol. 46, 823.
15. Piascik, M.T., R.D. Guarino, M.S. Smith, E.E. Soltis, D.L. Saussy Jr. and D.M. Perez, 1995, The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle, J. Pharmacol. Exp. Ther. 275, 1583.
16. 1-adrenergic receptor subtype classification, Mol. Pharmacol. 46, 221.
17. 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta, Life Sci. 57, 159.
18. 1A subtypes, Eur. J. Pharmacol. 298, 257.
19. Williamson, A.P., E. Seifen, J.P. Lindemann and R.H. Kennedy, 1994a, Effects of WB 4101 and chloroethylclonidine on the positive and negative inotropic action of phenylephrine in rat cardiac muscle, J. Pharmacol. Exp. Ther. 268, 1174.
20. Williamson, A.P., E. Seifen, J.P. Lindemann and R.H. Kennedy, 1994b, WB 4101 and CEC-sensitive positive inotropic action of phenylephrine in rat cardiac muscle, Am. J. Physiol. 266, H2462.
21. 1B-adrenoceptors in phenylephrine-induced positive inotropic response in isolated rat left atrium, J. Cardiovasc. Pharmacol. 24, 745.