Calmodulin content and in vitro contractility of duodenum from streptozotocin-induced diabetic rats: Effects of insulin therapy and calmodulin antagonism

European Journal of Pharmacology

Volumn 321, Issue 1, 1997, Pages 59-65

  Öztürk, Yusuf ^a   Aydin, Süleyman ^a   Özçelikay, A Tanju ^b   Altan, V Melih ^b   Yildizoǧlu Ari, Nuray ^b  

^a ANADOLU UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

Ca2+; Calmidazolium; Calmodulin; Diabetic rat; Insulin; Intestinal reactivity; Streptozotocin

Indexed keywords

CALCIUM ION; CALMIDAZOLIUM; CALMODULIN; CALMODULIN INHIBITOR; INSULIN; POTASSIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DUODENUM MOTILITY; INSULIN TREATMENT; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; STREPTOZOCIN DIABETES; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BLOOD GLUCOSE; CALMODULIN; DIABETES MELLITUS, EXPERIMENTAL; DUODENUM; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; POTASSIUM CHLORIDE; RATS; RATS, WISTAR;

EID: 0031577956     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00928-4     Document Type: Article

References (52)

1. Adelstein, R.S. and E. Eisenberg, 1980, Regulation and kinetics of actin-myosin-ATP interaction, Annu. Rev. Biochem. 49, 921.
2. Aihara, K. and Y. Sakai, 1989, Hyperreactivity of contractile response in gastric fundus smooth muscle from rats with diabetes induced by streptozotocin, Arch. Int. Pharmacodyn. Ther. 302, 220.
3. Altan, V.M., N. Yildizoǧlu and Y. Öztürk, 1987, Decreased gastro-intestinal responses to certain agonists in streptozotocin-and alloxan-diabetic rats in vitro, Pharmacology 34, 143.
4. Altan, V.M., Y. Öztürk, N. Yildizoǧlu, C. Nebigil, D. Lafçi and A.T. Özçelikay, 1989, Insulin action on different smooth muscle preparations, Gen. Pharmacol. 20, 529.
5. Ariëns, E.J. and A.M. Simonis, 1964, Drug receptor interaction: interaction of one or more drugs with a receptor system, in: Molecular Pharmacology: The Mode of Action of Biologically Active Compounds, Vol. 1, ed. E.J. Ariëns (Academic Press, New York, NY) p. 119.
6. x' values in analysis of pharmacodynamics, Arch. Int. Pharmacodyn. Ther. 110, 275.
7. Bargen, J.A., J.L. Bollman and E.J. Kepler, 1936, "Diarrhea of diabetes" and statorrhea of pancreatic insufficiency. Mayo Clin. Proc. 11, 737.
8. Britton, K.E., V. Quinn, B.L. Brown and R.P. Ekins, 1975, A strategy for thyroid function tests, Br. Med. J. iii, 350.
9. Brownlee, M., H. Vlassara, A. Klooney, P. Ulrich and A. Cerami, 1986, Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science 232, 1629.
10. Burgoyne, R.D. and M.J. Geisow, 1989, The annexin family of calcium-binding proteins, Cell Calcium 10, 1.
11. Carmichael, J.D., S.J. Winder, M.P. Walsh, G.J. Kargacin, 1994, Calponin and smooth muscle regulation, Can. J. Physiol. Pharmacol. 72, 1415.
12. Fales, F.W., J.A. Russell and J.N. Fain, 1961, Some applications and limitations of the enzymatic (Somogyi) and anthrone method for estimating sugars, Clin. Chem. 7, 389.
13. Finney, D.J., 1978, Statistical Methods in Biological Assay (Griffin, London).
14. Flower, R.J. and N.J. Rothwell, 1994. Lipocortin-1: cellular mechanisms and clinical relevance, Trends Pharmacol. Sci. 15, 71.
15. Gerthoffer, W.T. and J. Pohl, 1994. Caldesmon and calponin phosphorylation in regulation of smooth muscle contraction, Can. J. Physiol. Pharmacol. 72, 1410.
16. ++-transport ATPase and of calmodulin regulated functions, Biochem. Biophys. Res. Commun. 101, 418.
17. Haeberle, J.R. and M.E. Hemric, 1994, A model for the coregulation of smooth muscle actomyosin by caldesmon, calponin, tropomyosin, myosin regulatory light chain. Can. J. Physiol. Pharmacol. 72, 1400.
18. Heizmann, C.W. and W. Hunziker, 1991, Intracellular calcium binding proteins: more sites than insights, Trends Biochem. Sci. 16, 98.
19. Hosking, D.J., T. Bennett and J.R. Hampton, 1978, Diabetic autonomic neuropathy, Diabetes 27, 1043.
20. Karasu, Ç. and V.M. Altan, 1993, The role of endothelial cells on the alterations in vascular reactivity induced by insulin-dependent diabetes mellitus: effect of insulin treatment. Gen. Pharmacol. 24, 743.
21. Karasu, Ç., Y. Öztürk, N. Altan, N. Yildizoǧlu-Ari. C. Ikizler and V.M. Altan, 1990, Thyroid hormones mediated effect of insulin on alloxan diabetic rat atria, Gen. Pharmacol. 21, 735.
22. Kassander, P., 1958, Asymptomatic gastric retention of diabetics (gastroparesis diabeticorum), Ann. Int. Med. 48, 797.
23. Katz, L.A. and H. Spiro, 1966. Gastrointestinal manifestations of diabetes, New Engl. J. Med. 275, 1350.
24. Lafçi-Erol, D., V.M. Altan and Y. Öztürk, 1994, Increased α-adrenergic responsiveness of alloxan diabetic rat atria: effects of insulin therapy and thyroidectomy. Gen. Pharmacol. 25, 559.
25. MacLeod, K.M., 1985, The effect of insulin treatment on changes in vascular reactivity in chronic, experimental diabetes, Diabetes 34, 1160.
26. 2+ transport in streptozotocin diabetic cardiomyopathy in rats, Am. J. Physiol. 253, E202.
27. Malins, J.M. and J.M. French, 1957, Diabetic diarrhea, Q. J. Med. 26, 461.
28. Malone, J.I. and A.W. Root, 1981, Plasma free insulin concentrations: keystone to effective management of diabetes mellilus in children, J. Pediatr. 99, 862.
29. Mathison, R. and J.S. Davison, 1988. Modified smooth muscle responses of jejunum in streptozotocin-diabetic rats, J. Pharmacol. Exp. Ther. 244, 1045.
30. Mazzei, G.J., R.C. Sehatzman, R.C. Turner, W.R. Vogler and J.F. Kuo, 1984, Phospholipid sensitive Ca2+-dependent proteinkinase inhibition by R-24571, a calmodulin antagonist, Biochem. Pharmacol. 33, 125.
31. Ogbonmaya, K.I. and R. Arem, 1990, Diabetic diarrhea: pathophysiology, diagnosis and management, Arch. Intern. Med. 150, 262.
32. +-depolarized duodenum from alloxan-diabetic rats, Pharmacol. Res. Commun. 19, 597.
33. Öztürk, Y., N. Yildizoǧlu-Ari, A. Özüari, A.T. Özçelikay and V.M. Altan, 1990, Decreased β-adrenergic responses of rat small intestine due to non-insulin-dependent diabetes. Diabetes Res. CHn. Pract. 9, 123.
34. Öztürk, Y., S. Aydin, V.M. Altan, N. Yildizoǧlu-Ari and A.T. Özçelikay, 1994, Effect of short and long term streptozotocin diabetes on smooth muscle calmodulin levels in the rat. Cell Calcium 16, 81.
35. Öztürk, Y, V.M. Altan, A.T. Özçelikay and N. Yildizoglu-Ari, 1992a, Beneficial effect of insulin on the decreased gastrointestinal β-adrenergic responses in streptozotocin-diabetic rats: a contributing role of protein biosynthesis, Arch. Int. Pharmacodyn. Ther. 317, 81.
36. Öztürk, Y., V.M. Altan and N. Yildizoǧlu-Ari, 1992b, β-Adrenergic responsiveness of the gastrointestinal tract in diabetic rats, Pharmacol. Toxicol. 71, 250.
37. Öztürk, Y., V.M. Altan and N. Yildizoǧlu-Ari, 1996, Duration-dependent changes in calcium responsiveness in the alloxan-diabetic rat intestine, J. Diab. Compl. (in press).
38. Özüari, A., Y. Öztürk, N. Yildizoǧlu-Ari, A.T. Özçelikay and V.M. Altan, 1993, The effects of glyburide and insulin on the cardiac performance in rats with non-insulin-dependent diabetes mellitus, Gen. Pharmacol. 24, 165.
39. Perez de Garcia, B., G. Ahluwalia, A1R. Rhoads and W.L. West, 1980, Tissue levels of calmodulin in experimental diabetes, Ann. NY Acad. Sci. 356, 422.
40. Rosenberg, C.R., J.B. Modrak, J.M. Hassing, W.A. Al-Turk and S.J. Stohs, 1979, Glycosylated collagen, Biochem. Biophys. Res. Commun. 91, 498.
41. Schachter, D. and S. Kowarski, 1985, Vitamin D and the intestinal membrane calcium-binding protein, in: Calcium in Biological Systems, eds. R.P. Rubin, G.B. Weiss and J.W. Putney (Plenum Press, New York, NY) p. 515.
42. Sheridan, E.P. and C.C. Bailey, 1946, Diabetic nocturnal diarrhea, J. Am. Med. Assoc. 130, 632.
43. Spedding, M., 1985, Calcium antagonist subgroups, Trends Pharmacol. Sci. 6, 109-114.
44. Takiguchi, Y., N. Satoh, H. Hashimoto and M. Nakashima, 1989, Reversal effect of thyroxine on altered vascular reactivity in diabetic rats, J. Cardiovasc. Pharmacol. 13, 520.
45. Triggle, D.J., 1983, Calcium, the control of smooth muscle and bronchial hyperreactivity, Allergy 38, 1.
46. Van Bella, H., 1981, A potent inhibitor of calmodulin activated enzymes, Cell Calcium 2, 483.
47. Van Eldik, L.J. and D.M. Watterson, 1981, Reproducible production of antiserum against vertebrate calmodulin and determination of the immunoreactive site, J. Biol. Chem. 256, 4205.
48. Van Eldik, L.J., G. Piperno and D.M. Watterson, 1980, Comparative biochemistry of calmodulin and calmodulin-like proteins, Ann. NY Acad. Sci. 356, 36.
49. Walsh, M.P., B. Vallet, J.-C. Cavadore and J.G. Demaille, 1980, Homologous calcium-binding proteins in the activation of skeletal, cardiac, smooth muscle myosin-light chain kinases, J. Biol. Chem. 255, 335.
50. Yang, R., R. Arem and L. Chan, 1984, Gastrointestinal tract complications of diabetes mellitus, Arch. Intern. Med. 144, 1251.
51. Yildizoǧlu-Ari, N., O. Altinkurt, Y. Öztürk, V.M. Altan, C. Pekiner and Ç. Karasu, 1988, Decreased gastro-intestinal responses to salbutamol and serotonin in streptozotocin-induced diabetes: improving effect of insulin in vivo and in vitro, Gen. Pharmacol. 19, 665.
52. Zhang, Y., S. Moreland and R.S. Moreland, 1994, Regulation of vascular smooth muscle contraction: myosin light chain phosphorylation dependent and independent pathways, Can. J. Physiol. Pharmacol. 72, 1386.