Differential effect of codeine on coughs caused by mechanical stimulation of two different sites in the airway of guinea pigs

European Journal of Pharmacology

Volumn 329, Issue 1, 1997, Pages 93-97

  Takahama, Kazuo ^a   Wakuda, Ikuko ^a   Fukushima, Hidenao ^a   Isohama, Yoichiro ^a   Kai, Hirofumi ^a   Miyata, Takeshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

A fiber; C fiber; Codeine; Cough, codeine resistant; Larynx; Mechanical stimulation; Trachea bifurcation

Indexed keywords

ANTITUSSIVE AGENT; CAPSAICIN; CODEINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; COUGHING; GUINEA PIG; LARYNX; MALE; MECHANICAL STIMULATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REPRODUCIBILITY; TRACHEA;

EID: 0031577192     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)10110-8     Document Type: Article

References (22)

1. Bucsics A., Holzer P., Lembeck F. The substance P content of peripheral tissues in various mammals. Peptides. 4:1983;451-455.
2. Cadieux A., Springall D.R., Mulderry P.K., Rodrigo J., Ghatei M.A., Terenghi G., Bloom S.R., Polak J.M. Occurrence, distribution and ontogeny of CGRP immunoreactivity in the rat lung: effect of capsaicin treatment and surgical denervations. Neuroscience. 19:1986;605-625.
3. Forsberg K., Karlsson J.-A., Theodorsson E., Lundberg J.M., Persson C.G.A. Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in the guinea-pig. Pulm. Pharmacol. 1:1988;33-39.
4. Forsberg K., Karlsson J.-A., Lundberg J.M., Zackrisson C. Effect of partial laryngeal denervation on irritant-induced cough and bronchoconstriction in conscious guinea-pigs. J. Physiol. 422:1990;34P.
5. Fuchikami J., Takahama K., Kai H., Miyata T. Comparative study of the antitussive activity of Mai-Meu-Dong-Tang and codeine in normal and bronchitic guinea-pigs. Pharmacodyn. Ther. 9:1990;37-43.
6. Jancso G. Pathobiological reactions of C-fibre primary sensory neurones to peripheral nerve injury. Exp. Physiol. 77:1992;405-431.
7. Jancso N., Kiraly E., Jancso-Gabor A. Pharmacologically induced selective degeneration of chemosensitive primary neurons. Nature. 270:1977;741-743.
8. Karlsson J.-A., Lanner A.-S., Persson C.G.A. Airway opioid receptors mediate inhibition of cough and reflex bronchoconstriction in guinea pigs. J. Pharmacol. Exp. Ther. 252:1989;863-868.
9. Kummer W., Fischer A., Kurkowski R., Heym C. The sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double-labeling immunohistochemistry. Neuroscience. 49:1992;715-737.
10. Liu L., Simon S.A. A rapid capsaicin-activated current in rat trigeminal ganglion neurons. Proc. Natl. Acad. Sci. USA. 91:1994;738-741.
11. Lundberg J.M., Saria A. Capsaicin-induced desensitization of the airway mucosa to cigarette smoke, mechanical and chemical irritants. Nature. 302:1983;251-253.
12. Lundberg J.M., Brodin E., Saria A. Effects and distribution of vagal capsaicin-sensitive substance P neurons with special reference to trachea and lungs. Acta Physiol. Scand. 119:1983;243-252.
13. Maggi C.A., Meli A., Santicioli P. Four motor effects of capsaicin on guinea-pigs distal colon. Br. J. Pharmacol. 90:1987;651-660.
14. Manzini S., Conti S., Maggi C.A., Abelli L., Somma V., Del Bianco E., Geppetti P. Regional differences in the motor and inflammatory responses to capsaicin in guinea pig airways: correlation with content and release of substance P-like immunoreactivity. Am. Rev. Respir. Dis. 140:1989;936-941.
15. Martling C.-R. Sensory nerves containing tachykinins and CGRP in the lower airways. Functional implications for bronchoconstriction, vasodilation and protein extravasation. Acta Physiol. Scand. 130((Suppl.)):1987;1.
16. McEwan J.R., Choudry N.B., Fuller R.W. The effect of sulinduc on the abnormal cough reflex associated with dry cough. J. Pharmacol. Exp. Ther. 255:1990;161-164.
17. Palmer J.B.D., Cuss F.M.C., Mulderry P.K., Ghatei M.A., Springall D.R., Cadieux A., Bloom S.R., Polak J.M., Barnes P.J. Calcitonin gene-related peptide is located to human airway nerves and potently constricts human airway smooth muscle. Br. J. Pharmacol. 91:1987;95-101.
18. Stockwell M., Lang S., Vip R., Zintel T., White C., Gallagher C.G. Lack of importance of the superior laryngeal nerves in citric acid cough in humans. J. Appl. Physiol. 75:1993;613-617.
19. Tatar M., Sant'ambrogio G., Sant'ambrogio F.B. Laryngeal and tracheo-bronchial cough in anesthetized dogs. J. Appl. Physiol. 76:1994;2672-2679.
20. Widdicombe J.C. Respiratory reflexes from the trachea and bronchi of the cat. J. Physiol. 123:1954;55-70.
21. Widdicombe, J.G., 1989. Physiology of cough. In: Braga, P.C., Allegra, L. (Eds.), Cough. Raven, New York, NY, pp. 193-229.
22. Widdicombe J.G. Neurophysiology of the cough reflex. Eur. Respir. J. 8:1995;1193-1202.