Effect of dehydroepiandrosterone sulfate on carnitine acetyl transferase activity and L-carnitine levels in oophorectomized rats

Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

Volumn 1344, Issue 3, 1997, Pages 201-209

  Chiu, Kit Mui ^a   Schmidt, Mary J ^b   Shug, Austin L ^b,c   Binkley, Neil ^a   Gravenstein, Stefan ^a,d  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Metab Analysis Laboratories Inc   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

Carnitine acetyl transferase; Dehydroepiandrosterone; L Carnitine; Mitochondrial function; Oophorectomy; Postmenopause

Indexed keywords

CARNITINE; CARNITINE ACETYLTRANSFERASE; PRASTERONE SULFATE;

ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; FEMALE; HEART; HISTOCHEMISTRY; LIVER; MITOCHONDRIAL RESPIRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; OVARIECTOMY; PRIORITY JOURNAL; RAT;

ANIMALS; CARNITINE; CARNITINE O-ACETYLTRANSFERASE; DEHYDROEPIANDROSTERONE SULFATE; DIET; FEMALE; LIVER; MITOCHONDRIA, LIVER; MYOCARDIUM; OVARIECTOMY; OXYGEN CONSUMPTION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; ROTENONE; SUCCINATES; SUCCINIC ACID;

EID: 0031576829     PISSN: 00052760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2760(96)00141-5     Document Type: Article

References (51)

1. Heymsfield, S.B., Gallagher, D., Poehlman, E.T., Wolper, C., Nonas, K., Nelson, D. and Wang, Z.M. (1994) Menopausal changes in body composition and energy expenditure. Exp. Gerontol. 29, 377-389.
2. Poehlman, E.T., Goran, M.I., Gardner, A.W., Ades, P.A., Arciero, P.J., Katzman-Rooks, S.M., Montgomery, S.M., Toth, M.J., Sutherland, P.T. (1993) Determinants of decline in resting metabolic rate in aging females. Am. J. Physiol. 264, E450-455.
3. Rebuffe-Scrive, M., Eldh, J., Hafstrom, L.O. and Bjorntorp, P.L. (1986) Metabolism of mammary, abdominal, and femoral adipocytes in women before and after menopause. Metabolism 35, 792-797.
4. VandeWiele, R.L., MacDonald, P.C., Gurpide, E. and Lieberman, S. (1963) Studies on the secretion and interconversion of androgens. Recent Progr. Horm. Res. 19, 275-310.
5. Lashansky, G., Saenger, P., Fishman, K., Gautier, T., Mayes, D., Berg, G., Di Martino-Nardi, J. and Reiter, E. (1991) Normative data for adrenal steroidogenesis in a healthy pediatric population: age- and sex-related changes after adrenocorticotropin stimulation. J. Clin. Endocrinol. Metab. 73, 674-686.
6. Orentreich, N., Brind, J.L., Rizer, R.L. and Vogelman J.H. (1984) Age changes and sex differences in plasma dehydroepiandrosterone sulfate concentrations throughout adulthood. J. Clin. Endocrinol. Metab. 58, 551-555.
7. Rozenberg, S., Ham, H., Bosson, D., Peretz, A. and Robyn, C. (1990) Age, steroids and bone mineral content. Maturitas 12, 137-143.
8. De Pergola, G., Cospite, M.R., Giagulli, V.A., Giorgino, F., Garruti, G., Cignarelli, M. and Giorgino R. (1993) Insulin-like growth factor-1 (IGF-1) and dehydroepiandrosterone sulphate in obese women. Int. J. Obes. 17, 481-483.
9. Ohta, H., Masuzawa, T., Ikeda, T., Suda, Y., Makita, K. and Nozawa, S. (1992) Which is more osteoporosis-inducing, menopause or oophorectomy? Bone Miner. 19, 273-285.
10. Turner, R.T., Hannon, K.S., Demers, L.M., Buchanan, J. and Bell, N.H. (1989) Differential effect of gonadal function on bone histomorphometry in male and female rats. J. Bone Miner. Res. 4, 557-563.
11. Turner, R.T., Lifrak, E.T., Beckner, M., Wakley, G.K., Hannon, K.S. and Parker, L.N. (1990) Dehydroepiandrosterone reduces cancellous bone osteopenia in ovariectomized rats. Am. J. Physiol. 258, E673-E677.
12. Berdanier, C., Parente, J. and Mcintosh, M. (1993) Is dehydroepiandrosterone an antiobesity agent? FASEB J. 7, 414-419.
13. Kurzman, I.D., MacEwen, E.G. and Haffa, A.L.M. (1989) Reduction in body weight and cholesterol in spontaneously obese dogs by dehydroepiandrosterone. Int. J. Obes. 14, 95-104.
14. Arad, Y., Badimon, J.J., Badimon, L., Hembree, W.C. and Ginsberg, H.N. (1989) Dehydroepi-androsterone feeding prevents aortic fatty streak formation and cholesterol accumulation in cholesterol-fed rabbit. Arteriosclerosis 9, 159-166.
15. Buffington, C.K., Pourmotabbed, G. and Kitabchi, A.E. (1993) Case report: Amelioration of insulin resistance in diabetes with dehydroepiandrosterone. Am. J. Med. Sci. 306, 320-324.
16. Mohan, P.F. and Cleary, M.P. (1991) Short term effects of dehydroepiandrosterone treatment in rats on mitochondrial respiration. J. Nutr. 121, 240-250.
17. Yamada, J., Sakuma, M. and Suga, T. (1992) Induction of peroxisomal β-oxidation enzymes by dehydroepiandrosterone and its sulfate in primary cultures of rat hepatocytes. Biochim. Biophys. Acta. 1160, 231-236.
18. Brady, L.J., Ramsay, R.R. and Brady, P. (1991) Regulation of carnitine acyltransferase synthesis in lean and obese Zucker rats by dehydroepiandrosterone and clofibrate. J. Nutr. 121, 525-531.
19. Mohan, P.F. and Cleary, M.P. (1988) Effect of short-term DHEA adminstration on liver metabolism of lean and obese rats. Am. J. Physiol. 255, E1-E8.
20. Bellei, M., Battelli, D., Fornieri, C., Mori, G., Muscatello, U., Lardy, H. and Bobyleva, V. (1991) Changes in liver structure and function after short-term and long term treatment of rats with dehydroepiandrosterone. J. Nutr. 122, 967-976.
21. Costell, M., O'Connor, J.E. and Grisolia, S. (1989) Age-dependent decrease of carnitine content in muscle of mice and humans. Biochem. Biophys. Res. Commun. 161, 1135-1143.
22. Hansford, R.G. and Castro, F. (1982) Age-linked changes in the activity of enzymes of the tricarboxylate cycle and lipid oxidation, and of carnitine content, in muscles of the rat. Mech. Ageing Dev. 19, 191-201.
23. Hansford, R.G. (1978) Lipid oxidation by heart mitochondria from young adult and senescent rats. Biochem. J. 170, 285-295.
24. Treem, W.R., Stanley, C.A., Finegold, D.N., Hale, D.E. and Coates, P.M. (1988) Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle, and fibroblast. New Engl. J. Med. 319, 1331-1336.
25. Costell, M. and Grisolia, S. (1993) Effect of carnitine feeding on the levels of heart and skeletal muscle carnitine of elderly mice. FEBS Lett. 315, 43-46.
26. Wanner, C. and Horl, W.H. (1988) Carnitine abnormalities in patient with renal insufficiency. Pathophysiological and therapeutic aspects. Nephronology 50, 89-102.
27. Stanley, C.A. (1987) New genetic defects in mitochondrial fatty acid oxidation and carnitine deficiency. Adv. Pediatr. 34, 59-88.
28. Rebouche, C.J. and Paulson D.J. (1986) Carnitine metabolism and function in humans. Annu. Rev. Nutr. 6, 41-66.
29. Frost, H.M. and Jee, W.S.S. (1992) On the rat model of human osteopenias and osteoporosis. Bone Miner. 18, 227-236.
30. Tanaka, M.,Yano, S., Haseqawa, Y. and Nakao, K. (1994) Antiproliferative effect of the new aromatase inhibitor fadrozole on pre- and postmenopausal models of rat mammary tumor. Arzneimittel-Forsch. 44, 774-778.
31. Lilienthal, J.L., Jr., Zierler, K.L., Folk, B.P., Buka, R. and Riley, M.J. (1950) A reference base and system for analysis of muscle constituents. J. Biol. Chem. 182, 501-508.
32. Parvin, R. and Pande, S.V. (1977) Microdetermination of L-carnitine and carnitine acetyl transferase activity. Anal. Biochem. 79, 190-201.
33. Johnson, D. and Lardy, H. (1967) Isolation of liver or kidney mitochondria. Methods Enzymol. 10, 94-96.
34. Gornall, A.G., Bardawill, C.J. and David, M.M. (1949) Determination of plasma proteins by means of the biuret reaction. J. Biol. Chem. 177, 751-756.
35. Pande, S.V. and Blanchaer, M.C. (1971) Reversible inhibition of mitochondrial adenosine diphosphate phosphorylation by long chain acyl coenzyme A esters. J. Biol. Chem. 246, 402-411.
36. Estabrook, R.W. (1967) Mitochondrial respiratory control and the polarographic measurement of ADP:O ratios. Methods Enzymol. 10, 41-47.
37. Broderick, T.L., Christos, S.C., Wolf, B.A., DoDomenico, D., Shug, A.L. and Paulson, D.J. (1995) Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency. Metabolism 44, 499-505.
38. Rebouche, C.J. (1992) Carnitine function and requirements during the life cycle. FASEB J. 6, 3379-3386.
39. Bremer, J. (1990) The role of carnitine in intracellular metabolism. J. Clin. Chem. Clin. Biochem. 28, 297-301.
40. Turnbull, D.M., Bartlett, K., Stevens, D.L., Alberti, K.O.M.M., Gibson, G.J., Johnson, M.A., McCulloch, A.J. and Shettatt, H.S.A. (1984) Short-chain acyl-CoA dehydrogenase deficiency associated with a lipid-storage myopathy and secondary carnitine deficiency. N. Engl. J. Med. 311, 1232-1236.
41. Rebouche, C.J., and Engel, A.G. (1983) Carnitine metabolism and deficiency syndromes. Mayo Clin. Proc. 58, 533-540.
42. Chiu, K.M., Kiami, P.H., Schmidt, M.J., Havighurst, T.C., Shug, A.L., Daynes, R.A., Gravenstein, S. (1996) Correlation of serum L-carnitine and dehydroepiandrosterone sulfate (DHEAS) levels with age and gender in healthy adult people. (submitted).
43. Bremer, J. (1983) Carnitine - metabolism and functions. Physiol. Rev. 63, 1420-1480.
44. Brooks, D.E. (1975) Turnover of carnitine by rat tissues. Biochem. J. 148, 439-445.
45. Berdanier, C.D. and Mcintosh, M.K., 1989. Further studies on the effects of dehydroepiandrosterone on hepatic metabolism in BHE rats. Proc. Soc. Exp. Biol. Exp. 192, 242-247.
46. Rebouche, C.J. and Chenard, C.A. (1991) Metabolic fate of dietary carnitine in human adults: Identification and quantification of urinary and fecal metabolites. J. Nutr. 121, 539-546.
47. Welling, P.G., Thomsen, J.H., Shug, A.L. and Tse, F.L. (1979) Pharmacokinetics of L-carnitine in man following intravenous infusion of DL-carnitine. Int. J. Clin. Pharmacol. Biopharm. 17, 56-60.
48. Huth, P.H. and Shug, A.L. (1980) Properties of carnitine transport in rat kidney cortex slices. Biochim. Biophys. Acta 602, 621-634.
49. Rebouche, C.J. and Mack, D.L. (1984) Sodium gradient-stimulated transport of L-carnitine into renal brush border membrane vesicles: Kinetics, specificity, and regulation by dietary carnitine. Arch. Biochem. Biophys. 235, 393-402.
50. Rebouche, C.J. (1983) Effect of dietary carnitine isomers and Gg-butyrobetaine on L-carnitine biosynthesis and metabolism in the rat. J. Nutr. 113, 1906-1913.
51. Borum, P.R. (1980) Regulation of the carnitine concentration in plasma. In: Carnitine biosynthesis, metabolism, and functions (Frenkel, R.A. and McGarry, J.D., eds.), pp. 115-126, Academic Press, New York, NY.