Quantitative structure-activity relationships of benzoyliminothiadiazoline derivatives as angiotensin as II receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 4, 1997, Pages 385-388

  Hirata, Terukage ^b   Goto, Satoru ^a   Tamura, Koichi ^b   Okuhira, Masayasu ^b   Nagao, Yoshimitsu ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b WAKUNAGA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[5 ETHYL 3 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL] 1,3,4 THIADIAZOLIN 2 YLIDENE]CARBAMOYL] 1 CYCLOPENTENECARBOXYLIC ACID; ANGIOTENSIN RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IN VITRO STUDY; LIVER MEMBRANE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

ANIMALIA;

EID: 0031576821     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00026-7     Document Type: Article

References (10)

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5. 1H-NMR, IR, mass spectra and elemental analysis data, in full agreement with their assigned structures.
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7. (6) Hirata, T.; Shiro, M.; Nagao, Y. Heterocycles in press.
8. (7) The binding assay was peformed by the method described in ref. 2.
9. (8) Bumpus, F. M.; Catt, K. J.; Chiu, A. T.; DeGasparo, M.; Goodfriend, T.; Husain, A.; Peach, M. J.; Taylor, D. G. Jr.; Timmermans, P. B. M. W. M. Hypertension 1991, 17, 720.
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