Replacement of the phosphodiester linkage in oligonncleotides by an amide: Effect of backbone length on duplex stability with RNA complement

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 4, 1997, Pages 447-452

  De Mesmaeker, Alain ^a   Jouanno, Chantal ^a   Wolf, Romain M ^a   Wendeborn, Sebastian ^a  

^a CIBA GEIGY LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE;

ARTICLE; DRUG SYNTHESIS; HYBRIDIZATION; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

EID: 0031576820     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00037-1     Document Type: Article

References (25)

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4. d) For a recent review on backbone modifications see: De Mesmaeker, A.; Altmann, K.-H.; Waldner, A.; Wendeborn, S. Curr. Opin. Struct. Biol 1995, 5, 343-355.
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