Polypeptides for controlled release applications: Synthesis and preliminary characterization and release studies

International Journal of Pharmaceutics

Volumn 159, Issue 2, 1997, Pages 197-206

  Cook, Thomas J ^a   Amidon, Gordon L ^a   Yang, Victor C ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Controlled release; Poly(amino acids); Random co polymers; Sequential polypeptides

Indexed keywords

ETHINYLESTRADIOL; POLYMER; POLYPEPTIDE;

AMINO ACID ANALYSIS; ARTICLE; BIODEGRADATION; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; HYDROPHOBICITY; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

EID: 0031574448     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00308-6     Document Type: Article

References (26)

1. Anderson, J.M., Spilizewski, K.L., Hiltner, A., 1985. Poly-α-amino acids as biomedical polymers. In: Williams, D.F. (Ed.), Biocompatibility of Tissue Analogs. CRC Press, Boca Raton, FL, pp. 67-88.
2. Brack A., Trudelle Y. Molecular weight determination of polypeptides from viscosity measurements. Polym. Commun. 26:1985;369-370.
3. Cohen J., Siegel R.A., Langer R. Sintering technique for the preparation of polymer matrices for the controlled release of macromolecules. J. Pharm. Sci. 73:1984;1034-1037.
4. Dhall G.I., Krishna U., Sivaraman R., Datey S., Gaur L.N., Mehta S., Roy M., Saxena N.C., Yadav S.C., Viswanath P., Saxena B.N. Phase II clinical trial with biodegradable subdermal contraceptive implant Capronor (4.0 cm single implant). Contraception. 44:1991;409-417.
5. Dickinson H.R., Hiltner A., Gibbons D.F., Anderson J.M. Biodegradation of a poly(α-amino acid) hydrogel I. In vivo. J. Biomed. Mater. Res. 15:1981;577-589.
6. Doty P., Bradhury J.H., Holtzer A.M. Polypeptides. IV. The molecular weight, configuration and association of poly-γ-benzyl-L-glutamate in various solvents. J. Am. Chem. Soc. 78:1956;947-954.
7. Fauchère J.L., Charton M., Kier L.B., Verloop A., Pliska V. Amino acid side chain parameter for correlation studies in biology and pharmacology. Int. J. Pept. Protein Res. 32:1988;269-278.
8. Goren H.J. Sequential polypeptide synthesis. CRC Crit. Rev. Biochem. 2:1974;197-225.
9. Heller J. Development of poly(ortho esters) - A historical overview. Biomaterials. 11:1990;659-665.
10. Jones, J.H., 1977. Sequential polypeptide synthesis. In: Weinstein, B. (Ed.), Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins, Vol. 4. Marcel Dekker, New York, pp. 29-63.
11. Kovacs, J., Mayers, G.L., Johnson, R.H., et al., 1972. On the problem of racemization during the synthesis of sequential polypeptides. In: Lande, S. (Ed.), Progress in Peptide Research, Vol. 2. Gordon and Breach, New York, pp. 185-193.
12. Kumaki T., Sisido M., Imanishi Y. Antithrombogenicity and oxygen permeability of block and graft copolymers of polydimethylsiloxane and poly(α-amino acid). J. Biomed. Mater. Res. 19:1985;785-811.
13. Leong K.W., Brott B.C., Langer R. Bioerodible polyanhydrides as drug-carrier matrices. I. Characterization, degradation and release characteristics. J. Biomed. Mater. Res. 19:1985;941-955.
14. Marck K.W., Wildevuur C.R.H., Sederel W.L., Bantjes A., Feijen J. Biodegradability and tissue reaction of random copolymers of L-leucine, L-aspartic acid, and L-aspartic acid esters. J. Biomed. Mater. Res. 11:1977;405-422.
15. 3ProGluGlu-elements. J. Am. Chem. Soc. 114:1992;727-733.
16. Minoura N., Aiba S., Fujiwara Y. Copolymer matrices composed of L-leucine and N5-(3-hydroxypropyl)-L-glutamine as carrier of drugs. Makromol. Chem. Rapid Commun. 5:1984;643-648.
17. Odian, G., 1981. Principles of Polymerization, 2nd edn. Wiley, New York.
18. Ritger P.L., Peppas N.A. A simple equation for description of solute release I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J. Control. Release. 5:1987;23-36.
19. Sato H., Nakajima A., Hayashi T., Chen G.-W., Noishiki Y. Microheterophase structure, permeability, and biocompatibility of A-B-A triblock copolymer membranes composed of poly(γ-ethyl L-glutamate) as the A component and polybutadiene as the B component. J. Biomed. Mater. Res. 19:1985;1135-1155.
20. Sidman, K.R., Schwope, A.D., Steber, W.D., Rudolph, S.E., 1980a. Use of synthetic polypeptides in the preparation of biodegradable delivery systems for narcotic antagonists. In: Willette, R.E., Barnett, G. (Eds.), Naltrexone: Research Monograph, 28th edn., pp. 214-231.
21. Sidman K.R., Schwope A.D., Steber W.D., Rudolph S.E., Poulin S.B. Biodegradable, implantable sustained release systems based on glutamic acid copolymers. J. Membr. Sci. 7:1980;277-291.
22. Sidman K.R., Steber W.D., Schwope A.D., Schnaper G.R. Controlled release of macromolecules and pharmaceuticals from synthetic polypeptides based on glutamic acid. Biopolymers. 22:1983;547-556.
23. Solomon G.F., Ciutâ I.Z. Détermination de la viscosité intrinsèque de solutions de polymères par une simple détermination de la viscosité J. Appl. Polym. Sci. 6:1962;683-686.
24. Urry, D.W., Prasad, K.U., 1985. Syntheses, characterizations, and medical uses of the polypentapeptide of elastin and its analogs. In: Williams, D.F. (Ed.), Biocompatibility of Tissue Analogs. CRC Press, Boca Raton, FL, pp. 89-116.
25. Urry D.W., Parker T.M., Reid M.C., Gowda D.C. Biocompatibility of the bioelastic materials, poly(GVGVP) and its γ-irradiation cross-linked matrix: Summary of generic biological test results. J. Bioact. Compat. Polym. 6:1991;263-282.
26. Wood S.A., Lemons J.E., Prasad K.U., Urry D.W. In vitro calcification and in vivo biocompatibility of the cross-linked polypentapeptide of elastin. J. Biomed. Mater. Res. 20:1986;315-335.