Regulation of expression of ferritin H-chain and transferrin receptor by protoporphyrin IX

European Journal of Biochemistry

Volumn 250, Issue 3, 1997, Pages 764-772

  Coccia, Eliana M ^a   Perrotti, Edvige ^a   Stellacci, Emilia ^a   Orsatti, Roberto ^a   Del Russo, Nicoletta ^a   Marziali, Giovanna ^a   Testa, Ugo ^a   Battistini, Angela ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Ferritin; Iron regulatory protein; Protoporphyrin IX; Transferrin receptor

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; DEFEROXAMINE MESYLATE; FERRITIN; IRON REGULATORY FACTOR; PROTOPORPHYRIN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; FRIEND LEUKEMIA; GENE EXPRESSION REGULATION; HEME SYNTHESIS; LEUKEMIA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REPORTER GENE; SYNTHESIS;

ANIMALIA; FELIS CATUS;

EID: 0031574386     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.00764.x     Document Type: Article

References (59)

1. Battistini, A., Coccia, E. M., Marziali, G., Bulgarini, D., Scalzo, S., Fiorucci, G., Romeo, G., Affabris, E., Testa, U., Rossi, G. B. & Peschle, C. (1991a) Intracellular heme coordinately modulates globin chains synthesis, transferrin-receptor number and ferritin content in differentiating Friend erythroleukemia cells, Blood 78, 2098-2103.
2. Battistini, A., Marziali, G., Albertini, R., Habetswallner, D., Bulgarini, D., Coccia, E. M., Fiorucci, G., Romeo, G., Orsatti, R., Testa, U., Affabris, E., Peschle, C. & Rossi, G. B. (1991b) Positive modulation of hemoglobin, heme and transferrin-receptor synthesis by murine interferon-α and -β in differentiating Friend cells: pivotal role of heme synthesis, J. Biol. Chem. 266, 528-535.
3. Bhasker, C. R., Burgiel, G., Neupert, B., Emery-Goodman, A., Kühn, L. C. & May, B. K. (1993) The putative iron-responsive element in the human erythroid 5-aminolevulinate synthase mRNA mediates translational control, J. Biol. Chem. 268, 12699-12705.
4. Casey, J. L., Di Jeso, B., Rao, K., Klausner, R. D. & Harford, J. B. (1988a) Two genetic loci partecipate in the regulation by iron of the gene for the human transferrin-receptor, Proc. Natl Acad. Sci. USA 85, 1787-1791.
5. Casey, J. L., Hentze, M. W., Koeller, D. M., Caugham, S. W., Rouault, T. A. & Klausner, R. D. (1988b) Iron-responsive elements: Regulatory RNA sequences that control mRNA levels and translation, Science 240, 924-928.
6. Casey, J. L., Koeller, D. M., Ramin, V. C., Klausner, R. D. & Harford, J. B. (1989) Iron regulation of transferrin-receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3′ untranslated region of the mRNA, EMBO J. 8, 3693-3699.
7. Caughman, S. W., Hentze, M. W., Rovatti, A., Harford, J. B. & Klausner, R. D. (1988) The iron responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis, J. Biol. Chem. 263, 19048-19052.
8. Chan, R. Y. Y. Seiser, C., Schulman, H. M., Kühn, L. C. & Ponka, P. (1994) Regulation of transferrin-receptor mRNA expression. Distinct regulatory features in erythroid cells, Eur. J. Biochem. 220, 683-692.
9. Chirgwin, J. J., Przybyla, A. E., MacDonald, R. J. & Rutter, W. J. (1970) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry 18, 5294-5299.
10. Coccia, E. M., Profita, V., Fiorucci, G., Romeo, G., Affabris, E., Testa, U., Hentze, M. W. & Battistini, A. (1992) Modulation of ferritin H-chain expression in Friend erythroleukemia cells: transcriptional and translational regulation by hemin, Mol. Cell. Biol. 12, 3015-3022.
11. Coccia, E. M., Stellacci, E., Perotti, E., Marziali, G. & Battistini, A. (1994) Differential regulation of ferritin expression in Friend leukemia cells by iron, J. Biol. Regul. Homeostatic Agents 8, 81-87.
12. Coccia, E. M., Stellacci, E., Orsatti, R., Testa, U. & Battistini, A. (1995) Regulation of ferritin H-chain expression in differentiating Friend leukemia cells, Blood 86, 1570-1579.
13. Constable, A., Quick, S., Gray, N. K. & Hentze, M. W. (1992) Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function? Proc. Natl Acad. Sci. USA 89, 4554-4558.
14. Cox, T. C., Bawden, M. J., Martin, A. & May, B. K. (1991) Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA, EMBO J. 10, 1891-1902.
15. Dandekar, T., Stripecke, R., Gray, N. K., Goossen, B., Constable, A., Johansson, H. E. & Hentze, M. W. (1991) Identification of a novel iron-responsive element in murine and human erythroid 5-aminolevulinic acid synthase mRNA, EMBO J. 10, 1903-1909.
16. DeWet, J. R., Wood, K. U., De Luca, M., Helinski, D. R. & Subramani, S. (1987) Firefly luciferase gene: structure and expression in mammalian cells, Mol. Cell. Biol. 7, 725-737.
17. Eisenstein, R. S., Garcia-Mayol, D., Pettingell, W. & Munro, H. N. (1991) Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron, Proc. Natl Acad. Sci. USA 88, 688-692.
18. Goossen, B. & Hentze, M. W. (1992) Position is the critical determinant for function of iron-responsive elements as translational regulators, Mol. Cell. Biol. 12, 1959-1966.
19. Gray, N. K., Pantapoulous, K., Dandekar, T., Ackrell, B. A. & Hentze, M. W. (1996) Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements, Proc. Natl Acad. Sci. USA 91, 4925-4930.
20. Greiser-Wilke, I., Ostertag, W., Goldfarb, P., Lang, A., Furusawa, M. & Conscience, J. F. (1981) Inducibility of spleen focus-forming virus by BrdUrd is controlled by the differentiated state of the cell, Proc. Natl Acad. Sci. USA 75, 2995-2999.
21. Guo, B., Yu, Y. & Leibold, E. A. (1994) Iron regulates cytoplasmic levels ol a novel iron-responsive element-binding protein without aconitase activity, J. Biol. Chem. 269, 24252-24260.
22. Haile, D. J., Roualt, T. J., Harford, J. B. & Klausner, R. D. (1990) The inhibition of the iron responsive element RNA-protein interaction by heme does not mimic in vivo iron regulation, J. Biol. Chem. 265, 12786-12789.
23. Henderson, B. R., Seiser, C. & Kühn, L. C. (1993) Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements, J. Biol. Chem. 268, 27327-27334.
24. Henderson, B. R. & Kühn, L. C. (1995) Differential modulation of the RNA-binding proteins IRP-1 and IRP-2 in response to iron. IRP-2 inactivation requires translation of another protein, J. Biol. Chem. 270, 20509-20515.
25. Hentze, M. W., Keim, S., Papadopoulos, P., O'Brien, S., Modi, W., Drysdale, J., Leonard, W. J., Harford, J. B. & Klausner, R. D. (1986) Cloning characterization expression and chromosomal localization of a human ferritin heavy chain gene, Proc. Natl Acad. Sci. USA 83, 7226-7230.
26. Hentze, M. W., Caughman, S. W., Rouault, T. A., Barriocanal, J. G., Dancis, A., Harford, J. B. & Klausner, R. D. (1987) Identification of the iron-responsive element for the translational regulation of human ferritin mRNA, Science 238, 1570-1573.
27. Hentze, M. W., Caughman, S. W., Casey, J. L., Koeller, D. M., Rouault, T. A., Harford, J. B. & Klausner, R. D. (1988) A model for the structure and functions of iron-responsive elements, Gene (Amst.) 72, 201-208.
28. Hentze, M. W., Rouault, T. A., Harford, J. B. & Klausner, R. D. (1989) Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction, Science 244, 357-359.
29. Hentze, M. W. & Argos, P. (1991) Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase, Nucleic Acids Res, 99, 1739-1740.
30. Iwai, K., Klausner, R. D. & Rouault, T. A. (1995) Requirements for iron-regulated degradation of the RNA-binding protein, iron-regulatory protein 2, EMBO J. 14, 5350-5357.
31. Jensen, B. M., Sando, S. H., Grandjean, P., Wiggers, P. & Dalhoj, J. (1990) Screening with zinc protoporphyrin for iron deficiency in non-anemic female blood donors, Clin. Chem. 36, 846-848.
32. Kappas, A., Sassa, S., Galbraith, R. A. & Nordmann, Y. (1995) The porphyrias,. in The metabolic and molecular bases of inherited disease (Scriver, C. R., Beandet, A. L., Sly, W. S. & Valle, D., eds) pp. 2103-2159, McGraw-Hill, New York.
33. Klausner, R. D., Rouault, T. A. & Harford, J. B. (1993) Regulating the fate of mRNA: the control of cellular iron methabolism, Cell 72, 19-28.
34. Kühn, L. C. & Hentze, M. W. (1992) Coordination of cellular iron metabolism by post-transcriptional gene regulation, J. Inorg. Biochem. 47, 183-195.
35. Langer, E. E., Haining, R. G., Labbe, R. F., Jacobs, P., Crosby, E. F. & Finch, C. A. (1972) Erythrocyle protoporphyrin, Blood 40, 112-128.
36. Leibold, E. A. & Munro, H. N. (1987) Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes, J. Biol. Chem. 262, 7335-7341.
37. Leibold, E. A. & Munro, H. M. (1988) Cytoplasmatic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs, Proc. Natl Acad. Sci. USA 85, 2171-2175.
38. Lin, J. J., McQueen, S. D., Gaffield, L., Patino, M. M., Walden, W. E. & Thach, R. E. (1990a) Specificity of the induction of ferritin synthesis by hemin, Biochim. Biophys. Acta 1050, 146-150.
39. Lin, J. J., McQueen, S. D., Patino, M. M., Gaffield, L., Russel, D. A., Bielser, D., Bailey, C. C. & Thach, R. E. (1990b) Derepression of ferritin messenger RNA translation by hemin in vitro, Science 247, 74-77.
40. Louache, F. Testa, U., Pelicci, P., Thomopoulos, P., Titeux, M. & Rochant, H. (1984) Regulation of transferrin-receptors in human haematopoietic cell lines, J. Biol. Chem. 259, 11576-11582.
41. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with the folin phenol reagent, J. Biol. Chem. 193, 265-275.
42. May, B. K., Bhasker, M. J., Bawden, M. J. & Cox, T. C. (1990) Molecular regulation of 5-aminolevulinate synthase. Diseases related to heme biosynthesis, Mol. Biol. Med. 7, 405-421.
43. Melefors, O., Goossen, B., Johansson, H. E., Stripecke, R., Gray, N. K. & Hentze, M. W. (1993) Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells, J. Biol. Chem. 268, 5974-5978.
44. Milligan, J. F., Groebe, D. R., Witherell, G. W. & Uhlenbeck, O. C. (1987) Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates, Nucleic Acids Res. 15, 8783-8798.
45. Müllner, H. W., Rothenberger, S., Müller, A. M. & Kühn, L. C. (1992) In vivo and in vitro modulation of the mRNA-binding activity of iron-regulatory factor, Eur. J. Biochem. 208, 597-605.
46. Nakahashi, Y., Fujita, H., Taketani, S., Ishida, N., Kappas, A. & Sassa, S. (1992) The molecular defect of ferrochelatase in a patient with erythropoietic protoporphyria, Proc. Natl Acad Sci. USA 89, 281-285.
47. Palma, J. K. Gao, X., Lin, C.-H., Wu, S. & Solomon, W. B. (1994) Iron protoporphyrin IX (hemin) but not tin or zinc protoporphyrin IX can stimulate gene expression in K562 cells from enhancer elements containing binding sites for NF-E2, Blood 84, 1288-1297.
48. Pantopoulos, K., Gray, N. K. & Hentze, M. W. (1995) Differential regulation of two related RNA-hinding proteins, iron-regulatory protein (IRP) and IRPB, RNA 1, 155-163.
49. Rademakers, L. H. P. M., Koningsberger, J. C., Sorber, C. W. J., Baart de la Faille, H., Van Hattum, J. & Marx, J. J. M. (1993) Accumulation of iron in erythroblasts of patients with erythropoietic protoporphyria, Eur. J. Clin. Invest. 23, 130-138.
50. Rogers, J. & Munro, H. N. (1987) Translation of ferritin light and heavy subunit mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma cells, Proc. Natl Acad. Sci. USA 84, 2277-2281.
51. Rouault, T. A., Rao, K., Harford, J., Mattia, E. & Klausner, R. D. (1985) Hemin, chelatable iron, and the regulation of transferrin-receptors biosynthesis, J. Biol. Chem. 260, 14862-14866.
52. Rouault, T. A., Stout, C. D., Kaptain, S., Harford, J. B. & Klausner, R. D. (1991) Structural relationship between an iron-regulated RNA-binding protein (IRE-BP) and aconitase: functional implications, Cell 64, 881-883.
53. Samaniego, F., Chin, J., Iwai, K., Rouault, T. A. & Klausner, R. D. (1994) Molecular characterization of a second iron-responsive element binding protein, iron-regulatory protein 2. Structure, function, and post-translational regulation, J. Biol. Chem. 269, 30904-30910.
54. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular cloning: a laboratory manual, 2nd edn, Cold Spring Harbor Laboratory Press, Cold Spring Harbor NY.
55. Sassa, S. (1988) Heme stimulation of cellular growth and differentiation, Seminars Hematol. 25, 312-320.
56. Stearne, P. A., Pietersz, G. A. & Goding, J. W. (1985) cDNA cloning of the murine transferrin-receptor: sequenee of trans-membrane and adjacent regions, J. Immunol. 134, 3474-3479.
57. Theil, E. C. (1987) Ferritin: structure, gene regualtion, and cellular function in animals, plants, and microorganisms, Annu. Rev. Biochem. 56, 289-315.
58. Theil, E. C. (1990) Regulation of ferritin and transferrin-receptor mRNAs, J. Biol. Chem. 265, 4771-4774.
59. van Gelder, C. W. G., Gunderson, S. L. Jansen, F. J. R., Boelens, W. C., Polycarpou-Schwarz, M., Mattay, I. W. & van Venrooij, W. J. (1993) A complex secondary structure in U1A pre-mRNA that binds two molecules of U1A protein is required for regulation of polyadenylation, EMBO J. 12, 5191-5200.