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Volumn 250, Issue 3, 1997, Pages 661-669

Metabolic processing of gangliosides by human fibroblasts in culture - Formation and recycling of separate pools of sphingosine

Author keywords

Biosynthesis; Ganglioside; Recycling; Sphingamine; Sphingosine

Indexed keywords

GANGLIOSIDE; SPHINGANINE; SPHINGOSINE;

EID: 0031574237     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.00661.x     Document Type: Article
Times cited : (39)

References (45)
  • 2
    • 0025689587 scopus 로고
    • Metabolism and intracellular transport of glycosphingolipids
    • Schwarzmann, G. & Sandhoff, K. (1990) Metabolism and intracellular transport of glycosphingolipids, Biochemistry 29, 10865-10871.
    • (1990) Biochemistry , vol.29 , pp. 10865-10871
    • Schwarzmann, G.1    Sandhoff, K.2
  • 3
    • 0020109107 scopus 로고
    • Studies on the cell association of exogenously added sialo-glycolipids
    • Radsak, G., Schwarzmann, G. & Wiegandt, H. (1982) Studies on the cell association of exogenously added sialo-glycolipids, Hoppe-Seylers Z. Physiol. Chem. 363, 263-272.
    • (1982) Hoppe-Seylers Z. Physiol. Chem. , vol.363 , pp. 263-272
    • Radsak, G.1    Schwarzmann, G.2    Wiegandt, H.3
  • 5
    • 0025543251 scopus 로고
    • Patterns of endogenous gangliosides and metabolic processing of exogenous gangliosides in cerebellar granule cells during differentiation in culture
    • Riboni, L., Prinetti, A., Pitto, M. & Tettamanti, G. (1990) Patterns of endogenous gangliosides and metabolic processing of exogenous gangliosides in cerebellar granule cells during differentiation in culture, Neurochem. Res. 15, 1175-1183.
    • (1990) Neurochem. Res. , vol.15 , pp. 1175-1183
    • Riboni, L.1    Prinetti, A.2    Pitto, M.3    Tettamanti, G.4
  • 6
    • 0029786969 scopus 로고    scopus 로고
    • Metabolic processing of gangliosides by normal and Salla human fibroblasts in culture. A study performed by administering radioactive GM3 ganglioside
    • Chigorno, V., Tettamanti, G. & Sonnino, S. (1996) Metabolic processing of gangliosides by normal and Salla human fibroblasts in culture. A study performed by administering radioactive GM3 ganglioside, J. Biol. Chem. 271, 21738-21744.
    • (1996) J. Biol. Chem. , vol.271 , pp. 21738-21744
    • Chigorno, V.1    Tettamanti, G.2    Sonnino, S.3
  • 7
    • 0026022563 scopus 로고
    • Cell regulation by sphingosine and more complex sphingolipids
    • Merril, A. H. J. (1991) Cell regulation by sphingosine and more complex sphingolipids, J. Bioenerg. Biomembr. 23, 83-104.
    • (1991) J. Bioenerg. Biomembr. , vol.23 , pp. 83-104
    • Merril, A.H.J.1
  • 8
    • 0022974603 scopus 로고
    • Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets
    • Hannun, Y. A., Loomis, C. R., Merril, A. H. & Bell, R. M. (1986) Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets, J. Biol. Chem. 261, 12604-12609.
    • (1986) J. Biol. Chem. , vol.261 , pp. 12604-12609
    • Hannun, Y.A.1    Loomis, C.R.2    Merril, A.H.3    Bell, R.M.4
  • 9
    • 0027434784 scopus 로고
    • The role of sphingosine in cell growth regulation and transmembrane signaling
    • Spiegel, S., Olivera, A. & Carlson, R. O. (1993) The role of sphingosine in cell growth regulation and transmembrane signaling, Adv. Lipid Res. 25, 105-129.
    • (1993) Adv. Lipid Res. , vol.25 , pp. 105-129
    • Spiegel, S.1    Olivera, A.2    Carlson, R.O.3
  • 10
    • 0021883202 scopus 로고
    • Incorporation and metabolism of ganglioside GM2 in skin fibroblasts from normal and GM2 gangliosidosis subjects
    • Sonderfeld, S., Conzelmann, E., Schwarzmann, G., Burg, J., Hinrichs, U. & Sandhoff, K. (1985) Incorporation and metabolism of ganglioside GM2 in skin fibroblasts from normal and GM2 gangliosidosis subjects, Eur. J. Biochem. 149, 247-255.
    • (1985) Eur. J. Biochem. , vol.149 , pp. 247-255
    • Sonderfeld, S.1    Conzelmann, E.2    Schwarzmann, G.3    Burg, J.4    Hinrichs, U.5    Sandhoff, K.6
  • 11
    • 0025708339 scopus 로고
    • Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver
    • Trinchera, M., Ghidoni, R., Sonnino, S. & Tettamanti, G. (1990) Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver, Biochem. J. 270, 815-820.
    • (1990) Biochem. J. , vol.270 , pp. 815-820
    • Trinchera, M.1    Ghidoni, R.2    Sonnino, S.3    Tettamanti, G.4
  • 12
    • 0026600013 scopus 로고
    • Rat cerebellar granule cells in culture associate and metabolize differently exogenous GM1 ganglioside molecular species containing a C18 or C20 long-chain base
    • Valsecchi, M., Chigorno, V., Sonnino, S. & Tettamanti, G. (1992) Rat cerebellar granule cells in culture associate and metabolize differently exogenous GM1 ganglioside molecular species containing a C18 or C20 long-chain base, Chem. Phys. Lipids 60, 247-252.
    • (1992) Chem. Phys. Lipids , vol.60 , pp. 247-252
    • Valsecchi, M.1    Chigorno, V.2    Sonnino, S.3    Tettamanti, G.4
  • 13
    • 0027154901 scopus 로고
    • Metabolism of exogenous ganglioside GM1 in cultured cerebellar granule cells - The fatty acid and sphingosine moieties formed during degradation are re-used for lipid biosynthesis
    • Riboni, L., Bassi, R., Conti, M. & Tettamanti, G. (1993) Metabolism of exogenous ganglioside GM1 in cultured cerebellar granule cells - The fatty acid and sphingosine moieties formed during degradation are re-used for lipid biosynthesis, FEBS Lett. 322, 257-260.
    • (1993) FEBS Lett. , vol.322 , pp. 257-260
    • Riboni, L.1    Bassi, R.2    Conti, M.3    Tettamanti, G.4
  • 14
    • 0027074149 scopus 로고
    • Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturated by cultured cells
    • Rother, J., van Echten, G., Schwarzmann, G. & Sandhoff, K. (1992) Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturated by cultured cells, Biochem. Biophys. Res. Commun. 189, 14-20.
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 14-20
    • Rother, J.1    Van Echten, G.2    Schwarzmann, G.3    Sandhoff, K.4
  • 15
    • 0014008349 scopus 로고
    • Enzymatic synthesis of ceramide
    • Sribney, M. (1966) Enzymatic synthesis of ceramide, Biochim. Biophys. Acta 125, 542-547.
    • (1966) Biochim. Biophys. Acta , vol.125 , pp. 542-547
    • Sribney, M.1
  • 16
    • 0014961287 scopus 로고
    • Specificity in ceramide biosynthesis from long-chain bases and various fatty acyl coenzyme A's by brain microsomes
    • Morell, P. & Radin, N. S. (1970) Specificity in ceramide biosynthesis from long-chain bases and various fatty acyl coenzyme A's by brain microsomes, J. Biol. Chem. 245, 342-350.
    • (1970) J. Biol. Chem. , vol.245 , pp. 342-350
    • Morell, P.1    Radin, N.S.2
  • 17
    • 0015523720 scopus 로고
    • Glycosphingolipids in cultured human skin fibroblasts. I. Characterization and metabolism in normal fibroblasts
    • Dawson, G., Matalon, R. & Dorfman, A. (1972) Glycosphingolipids in cultured human skin fibroblasts. I. Characterization and metabolism in normal fibroblasts, J. Biol. Chem. 247, 5944-5950.
    • (1972) J. Biol. Chem. , vol.247 , pp. 5944-5950
    • Dawson, G.1    Matalon, R.2    Dorfman, A.3
  • 18
    • 0025012620 scopus 로고
    • Aggregation properties of GM3 ganglioside (II'Neu5-AcLacCer) in aqueous solutions
    • Sonnino, S., Cantu', L., Acquotti, D., Corti, M. & Tettamanti, G. (1990) Aggregation properties of GM3 ganglioside (II'Neu5-AcLacCer) in aqueous solutions, Chem. Phys. Lipids 52, 231-241.
    • (1990) Chem. Phys. Lipids , vol.52 , pp. 231-241
    • Sonnino, S.1    Cantu', L.2    Acquotti, D.3    Corti, M.4    Tettamanti, G.5
  • 21
    • 0000884058 scopus 로고
    • Biochemistry of the sphingolipids: XII. conversion of cerebrosides to ceramides and sphingosine; structure of Gaucher cerebroside
    • Carter, H. E., Rothfus, J. A. & Gigg, R. (1961) Biochemistry of the sphingolipids: XII. conversion of cerebrosides to ceramides and sphingosine; structure of Gaucher cerebroside, J. Lipid Res. 2, 228-234.
    • (1961) J. Lipid Res. , vol.2 , pp. 228-234
    • Carter, H.E.1    Rothfus, J.A.2    Gigg, R.3
  • 22
    • 0029820989 scopus 로고    scopus 로고
    • Preparation of radiolabeled gangliosides
    • Sonnino, S., Nicolini, M. & Chigorno, V. (1996) Preparation of radiolabeled gangliosides, Glycobiology 6, 479-487.
    • (1996) Glycobiology , vol.6 , pp. 479-487
    • Sonnino, S.1    Nicolini, M.2    Chigorno, V.3
  • 23
    • 0019644370 scopus 로고
    • Specific tritium labeling of gangliosides at the 3-position of sphingosines
    • Ghidoni, R., Sonnino, S., Masserini, M., Orlando, P. & Tettamanti, G. (1981) Specific tritium labeling of gangliosides at the 3-position of sphingosines, J. Lipid Res. 22, 1286-1295.
    • (1981) J. Lipid Res. , vol.22 , pp. 1286-1295
    • Ghidoni, R.1    Sonnino, S.2    Masserini, M.3    Orlando, P.4    Tettamanti, G.5
  • 24
    • 0021167265 scopus 로고
    • High performance liquid chromatography preparation of the molecular species of GM1 and GD1a gangliosides with homogeneous long-chain base composition
    • Sonnino, S., Ghidoni, R., Gazzotti, G., Kirschner, G., Galli, G. & Tettamanti, G. (1984) High performance liquid chromatography preparation of the molecular species of GM1 and GD1a gangliosides with homogeneous long-chain base composition, J. Lipid Res. 25, 620-629.
    • (1984) J. Lipid Res. , vol.25 , pp. 620-629
    • Sonnino, S.1    Ghidoni, R.2    Gazzotti, G.3    Kirschner, G.4    Galli, G.5    Tettamanti, G.6
  • 25
    • 0021856673 scopus 로고
    • Preparation of GM1 ganglioside molecular species having homogeneous fatty acid and long-chain base moieties
    • Sonnino, S., Kirschner, G., Ghidoni, R., Acquotti, D. & Tettamanti, G. (1985) Preparation of GM1 ganglioside molecular species having homogeneous fatty acid and long-chain base moieties, J. Lipid Res. 26, 248-257.
    • (1985) J. Lipid Res. , vol.26 , pp. 248-257
    • Sonnino, S.1    Kirschner, G.2    Ghidoni, R.3    Acquotti, D.4    Tettamanti, G.5
  • 27
    • 0027413499 scopus 로고
    • The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver
    • Hirschberg, K., Rodger, J. & Futerman, A. H. (1993) The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver, Biochem. J. 290, 751-757.
    • (1993) Biochem. J. , vol.290 , pp. 751-757
    • Hirschberg, K.1    Rodger, J.2    Futerman, A.H.3
  • 28
    • 0024978422 scopus 로고
    • Isolation and characterization of ceramide glycanase from the leech Macrobdella decora
    • Zhou, B., Li, S. C., Laine, R. A., Huang, R. T. C. & Li, Y. T. (1989) Isolation and characterization of ceramide glycanase from the leech Macrobdella decora, J. Biol. Chem. 264, 12272-12277.
    • (1989) J. Biol. Chem. , vol.264 , pp. 12272-12277
    • Zhou, B.1    Li, S.C.2    Laine, R.A.3    Huang, R.T.C.4    Li, Y.T.5
  • 29
    • 0014861488 scopus 로고
    • Preparation of lyso-hematoside (neuraminyl-galactosyl-glucosylsphingosine) from hematoside of equine erythrocyte and its chemical and hemolytic properties
    • Taketomi, T. & Kawamura, N. (1970) Preparation of lyso-hematoside (neuraminyl-galactosyl-glucosylsphingosine) from hematoside of equine erythrocyte and its chemical and hemolytic properties, J. Biochem. (Tokyo) 68, 475-485.
    • (1970) J. Biochem. (Tokyo) , vol.68 , pp. 475-485
    • Taketomi, T.1    Kawamura, N.2
  • 31
    • 0015929369 scopus 로고
    • A new procedure for the extraction and purification and fractionation of brain gangliosides
    • Tettamanti, G., Bonali, F., Marchesini, S. & Zambotti, V. (1973) A new procedure for the extraction and purification and fractionation of brain gangliosides, Biochim. Biophys. Acta 296, 160.
    • (1973) Biochim. Biophys. Acta , vol.296 , pp. 160
    • Tettamanti, G.1    Bonali, F.2    Marchesini, S.3    Zambotti, V.4
  • 32
    • 0027973462 scopus 로고
    • A simple and quantitative purification of glycosphingolipids and phospholipids by thin-layer chromatographic blotting
    • Taki, T., Handa, S. & Ishikawa, D. (1994) A simple and quantitative purification of glycosphingolipids and phospholipids by thin-layer chromatographic blotting, Anal. Biochem. 223, 232-238.
    • (1994) Anal. Biochem. , vol.223 , pp. 232-238
    • Taki, T.1    Handa, S.2    Ishikawa, D.3
  • 33
    • 0029800158 scopus 로고    scopus 로고
    • Changes of free long-chain bases in neuronal cells during differentiation and aging in culture
    • Valsecchi, M., Chigorno, V., Nicolini, M. & Sonnino, S. (1996) Changes of free long-chain bases in neuronal cells during differentiation and aging in culture, J. Neurochem. 67, 1866-1871.
    • (1996) J. Neurochem. , vol.67 , pp. 1866-1871
    • Valsecchi, M.1    Chigorno, V.2    Nicolini, M.3    Sonnino, S.4
  • 37
    • 49749155713 scopus 로고
    • Quantitative estimation of sialic acid. II. A colorimetric resorcinol-hydrochloric acid method
    • Svennerholm, L. (1957) Quantitative estimation of sialic acid. II. A colorimetric resorcinol-hydrochloric acid method. Biochim. Biophys. Acta 24, 604-611.
    • (1957) Biochim. Biophys. Acta , vol.24 , pp. 604-611
    • Svennerholm, L.1
  • 38
    • 0001687930 scopus 로고
    • Use of butyl acetate in determination of sialic acid
    • Miettinen, J. & Takki-Lukkainen, J. T. (1959) Use of butyl acetate in determination of sialic acid, Acta Chem. Scand. 13, 856-858.
    • (1959) Acta Chem. Scand. , vol.13 , pp. 856-858
    • Miettinen, J.1    Takki-Lukkainen, J.T.2
  • 39
    • 0024494262 scopus 로고
    • Age and cell density dependent changes of gangliosides in human diploid fibroblasts
    • Ohsawa, T. (1989) Age and cell density dependent changes of gangliosides in human diploid fibroblasts, Exp. Gerontol. 24, 1-9.
    • (1989) Exp. Gerontol. , vol.24 , pp. 1-9
    • Ohsawa, T.1
  • 40
    • 0024791059 scopus 로고
    • Metabolism of free sphingoid bases in murine tissues and in cultured human fibroblasts
    • Kobayushi, T., Shinnoh, N. & Goto, I. (1989) Metabolism of free sphingoid bases in murine tissues and in cultured human fibroblasts, Eur. J. Biochem. 186, 493-499.
    • (1989) Eur. J. Biochem. , vol.186 , pp. 493-499
    • Kobayushi, T.1    Shinnoh, N.2    Goto, I.3
  • 41
    • 0024500864 scopus 로고
    • A photoreactive derivative of radiolabeled GM1 ganglioside: Preparation and use to establish the involvement of specific proteins in GM1 uptake by human fibroblasts in culture
    • Sonnino, S., Chigorno, V., Acquotti, D., Pitto, M., Kirschner, G. & Tettamanti, G. (1989) A photoreactive derivative of radiolabeled GM1 ganglioside: preparation and use to establish the involvement of specific proteins in GM1 uptake by human fibroblasts in culture, Biochemistry 28, 77-84.
    • (1989) Biochemistry , vol.28 , pp. 77-84
    • Sonnino, S.1    Chigorno, V.2    Acquotti, D.3    Pitto, M.4    Kirschner, G.5    Tettamanti, G.6
  • 42
    • 0021979912 scopus 로고
    • Organization of glycosphingolipids in bilayer and plasma membranes of mammalian cells
    • Thompson, T. E. & Tillack, T. W. (1985) Organization of glycosphingolipids in bilayer and plasma membranes of mammalian cells, Annu. Rev. Biophys. Chem. 14, 361-386.
    • (1985) Annu. Rev. Biophys. Chem. , vol.14 , pp. 361-386
    • Thompson, T.E.1    Tillack, T.W.2
  • 45
    • 84987566733 scopus 로고
    • The nomenclature of lipids
    • IUPAC-IUB Commission on Biochemical Nomenclature (1977) The nomenclature of lipids, Eur. J. Biochem. 79, 11-21.
    • (1977) Eur. J. Biochem. , vol.79 , pp. 11-21


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