Moisture absorption and desorption of different rubber lyophilisation closures

International Journal of Pharmaceutics

Volumn 159, Issue 1, 1997, Pages 57-65

  Corveleyn, Sam ^a   De Smedt, Stefaan ^a   Remon, Jean Paul ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Lyophilisation; Moisture absorption; Rubber stoppers

Indexed keywords

BROMOBUTYL RUBBER; POLYMER; RUBBER; UNCLASSIFIED DRUG;

ABSORPTION; ARTICLE; ATMOSPHERIC PRESSURE; CHLOROBUTYL RUBBER; CONTROLLED STUDY; DESORPTION; DEVICE; FREEZE DRYING; HUMIDITY; MOISTURE; PRIORITY JOURNAL; TEMPERATURE; WATER VAPOR;

EID: 0031573910     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00263-9     Document Type: Article

References (9)

1. Avis, K., Lachman, L., Lieberman, H.A., 1986. Pharmaceutical Dosage Forms: Parenteral Medication, Vol 2. Marcel Dekker, New York.
2. DeGrazio F.L., Flynn K. Lyophilisation closures for protein based drugs. J. Parent. Sci. Technol. 46:1992;54-61.
3. Manning C.M., Patel K., Borchardt R.T. Stability of protein pharmaceuticals. Pharm. Res. 6:1989;903-918.
4. Pikal, M.J., 1991. Freeze-drying of proteins. II Formulation Selection. Pharm. Tech. Int. 2, 40-43.
5. Pikal M.J., Shah S. Moisture transfer from stopper to product and resulting stability implications. Dev. Biol. Stand. 74:1991;165-179.
6. Swarbrick, J., Boylan, J.C., 1992. Elastomeric parenteral closures. In: Encyclopedia of Pharmaceutical Technology, Vol. 5. Marcel Dekker, New York, pp. 73-88.
7. Vromans H., Van Laarhoven J.A.H. A study on water permeation through rubbers closures of injection vials. Int. J. Pharm. 79:1992;301-308.
8. PDA, elastomeric closures: evaluation of significant performance and identity characteristics. Tech. Methods Bull. 2, 21-24.
9. Handbook of Chemistry and Physics, 1971. 52nd ed. R.C. Weast. Chemical Rubber, OH.