Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21

Genomics

Volumn 46, Issue 3, 1997, Pages 450-458

  Bergstein, Ivan ^a   Eisenberg, Leonard M ^b   Bhalerao, Jayant ^d   Jenkins, Nancy A ^e   Copeland, Neal G ^d   Osborne, Michael P ^a,e   Bowcock, Anne M ^c   Brown, Anthony M C ^a,c  

^a Strang Cancer Research Laboratory   (United States)

^b Dept of Cell Biology and Anatomy ^*  (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL SEQUENCE; ARTICLE; BREAST; CELL GROWTH; CHROMOSOME 1; CHROMOSOME 17Q; CHROMOSOME ANALYSIS; CHROMOSOME MAP; GENE EXPRESSION; GENE ISOLATION; GENE STRUCTURE; HUMAN; HUMAN CELL; MAMMARY GLAND FUNCTION; MULTIGENE FAMILY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0031573781     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.5041     Document Type: Article

References (52)

1. Adamson, M. C., Dennis, C., Delaney, S., Christiansen, J., Monkley, S., Kozak, C. A., and Wainwright, B. (1994). Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a. Genomics 24: 9-13.
2. Albertsen, H. M., Abderrahim, H., Cann, H. M., Dausset, J., Le Paslier, D., and Cohen, D. (1990). Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents. Proc. Natl. Acad. Sci. USA 87: 4256-4260.
3. Arheden, K., Mandahl, N., Strombeck, B., Isaksson, M., and Mitelman, F. (1988). Chromosomal localization of the human oncogene INT1 to 12q13 by in situ hybridization. Cytogenet. Cell Genet. 47: 86-87.
4. Bradley, R. S., and Brown, A. M. C. (1990). The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix. EMBO J. 9: 1569-1575.
5. Bradley, R. S., and Brown, A. M. C. (1995). A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells. Mol. Cell. Biol. 15: 4616-4622.
6. Brownstein, B. H., Silverman, G. A., Little, R. D., Burke, D. T., Korsmeyer, S. J., Schlessinger, D., and Olson, M. V. (1989). Isolation of single-copy human genes from a library of yeast artificial chromosome clones. Science 244: 1348-1351.
7. Buchberg, A. M., Brownell, E., Nagata, S., Jenkins, N. A., and Copeland, N. G. (1989). A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics 122: 153-161.
8. Bui, T. D., Rankin, J., Smith, K., Huguet, E. L., Ruben, S., Strachan, T., Harris, A. L., and Lindsay, S. (1997). A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas. Oncogene 14: 1249-1253.
9. Callahan, R., Cropp, C., Gallahan, D., Liscia, D., Merlo, G., Smith, G. H., and Lidereau, R. (1992). The genetic pathology of breast cancer. Prog. Clin. Biol. Res. 376: 117-136.
10. Chandrasekharappa, S. C., King, S. E., Freedman, M. L., Hayes, S. T., Bowcock, A. M., and Collins, F. S. (1993). The CA repeat marker D17S791 is located within 40 kb of the WNT3 gene on chromosome 17q. Genomics 18: 728-729.
11. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
12. Clark, C. C., Cohen, I., Eichstetter, I., Cannizzaro, L. A., McPherson, J. D., Wasmuth, J. J., and Iozzo, R. V. (1993). Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. Genomics 18: 249-260.
13. Copeland, N. G., and Jenkins, N. A. (1991). Development and applications of a molecular genetic linkage map of the mouse genome. Trends Genet. 7(133): 113-118.
14. Cropp, C. S., Champene, M. H., Lidereau, R., and Callahan, R. (1993). Identification of three regions on chromosome 17q in primary human breast carcinomas which are frequently deleted. Cancer Res. 53: 5617-5619.
15. Danielson, K. G., Pillarisetti, J., Cohen, I. R., Sholehvar, B., Huebner, K., Ng, L.-J., Nichols, J. M., Cheah, K. S. E., and Iozzo, R. V. (1995). Characterization of the complete genomic structure of the human WNT-5A gene, functional analysis of its promoter, chromosomal mapping, and expression in early human embryogenesis. J. Biol. Chem. 270: 31225-31234.
16. Dealy, C. N., Roth, A., Ferrari, D., Brown, A. M. C., and Kosher, R. A. (1993). Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes. Mech. Dev. 43: 175-186.
17. Eisenberg, L. M., Ingham, P. W., and Brown, A. M. C. (1992). Cloning and characterization of a novel Drosophila Wnt gene, Dwnt-5, a putative downstream target of the homeobox gene Distal-less. Dev. Biol. 154: 73-83.
18. Gaffney, E. V. (1982). A cell line (HBL100) established from human breast milk. Cell Tissue Res. 227: 563-568.
19. Gavin, B. J., McMahon, J. A., and McMahon, A. P. (1990). Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 4: 2319-2332.
20. Graba, Y., Giesler, K., Aragnol, D., Laurenti, P., Mariol, M., Berenger, H., Sagnier, T., and Pradel, J. (1995). DWnt-4, a novel Drosophila Wnt gene, acts downstream of homeotic complex genes in the visceral mesoderm. Development 121: 209-218.
21. Hall, J. M., Lee, M. K., Newman, B., Morrow, J. E., Anderson, L. A., Huey, B., and King, M.-C. (1990). Linkage of early onset familial breast cancer to chromosome 17q21. Science 250: 1684-1689.
22. Hudson, T. J., Stein, L. D., Gerety, S. S., Ma, J., Castle, A. B., Silva, J., Slonim, D. K., Baptista, R., Kruglyak, L., Xu, S. H., Hu, X., Colbert, A., Rosenberg, C., Reeve-Daly, M. P., Rozen, S., Hui, L., Wu, X., Vestergaard, C., Wilson, K., Bae, J., Maitra, S., Ganiatsas, S., Evans, C., DeAngelis, M., Ingalls, K., Nahf, R., Horton, L., Oskin, M., Collymore, A., Ye, W., Kouyoumjian, V., Zernsteva, I., Tarn, J., Devine, R., Courtney, D., Renaud, M., Nguyen, H., O'Connor, T., Fizames, C., Faure, S., Gyapay, G., Dib, C., Morissette, J., Orlin, J., Birren, B., Goodman, N., Weissenbach, J., Hawkins, T., Foote, S., Page, D., and Lander, E. (1995). An STS-based map of the human genome. Science 270: 1945-1954.
23. Huguet, E. L., McMahon, J. A., McMahon, A. P., Bicknell, R., and Harris, A. L. (1994). Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and diseased breast tissue. Cancer Res. 54: 2615-2621.
24. Iozzo, R. V., Eichstetter, I., and Danielson, K. G. (1995). Aberrant expression of the growth factor Wnt-5a in human malignancy. Cell Regul. 55: 3495-3499.
25. Jenkins, N. A., Copeland, N. G., Taylor, B. A., and Lee, B. K. (1982). Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J. Virol. 43: 26-36.
26. Kamb, A., Weir, M., Rudy, B., Varmus, H., and Kenyon, C. (1989). Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. Proc. Natl. Acad. Sci. USA 86: 4372-4376.
27. Katoh, M., Hirai, M., Sugimura, T., and Terada, M. (1996). Cloning, expression, and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. Oncogene 13: 873-876.
28. Lee, F. S., Lane, T. F., Kuo, A., Shackleford, G. M., and Leder, P. (1995). Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice. Proc. Natl. Acad. Sci. USA 92: 2268-2272.
29. Lejeune, S., Huguet, E. L., Hamby, A., Poulsom, R., and Harris, A. L. (1995). Wnt5a cloning, expression, and up-regulation in human primary breast cancers. Clin. Cancer Res. 1: 215-222.
30. Lundin, L. G. (1993). Evolution of the vertebrate genome as reflected in paralogous chromosomal regions in man and the house mouse. Genomics 16: 1-19.
31. Miki, Y., et al. (1994). A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66-71.
32. Moon, R. T., Christian, J. L., Campbell, R. M., McGrew, L. L., De-Marais, A. A., Torres, M., Lai, C., Olson, D. J., and Kelly, G. M. (1993). Dissecting Wnt signaling pathways and Wnt-sensitive developmental processes through transient misexpression analyses in embryos of Xenopus laevis. Development 119(Suppl.): 85-94.
33. Moon, R. T., Brown, J. D., and Torres, M. (1997). WNTs modulate cell fate and behavior during vertebrate development. Trends Genet. 13: 157-162.
34. Murakami, Y. S., Brothman, A. R., Leach, R. J., and White, R. L. (1995). Suppression of malignant phenotype in a human prostate cancer cell line by fragments of normal chromosome region 17q. Cancer Res. 55: 3389-3394.
35. Nusse, R. (1991). Insertional mutagenesis in mouse mammary tumorigenesis. Curr. Top. Microbiol. Immunol. 171: 43-66.
36. Nusse, R., and Varmus, H. E. (1982). Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31: 99-109.
37. Nusse, R., and Varmus, H. E. (1992). Wnt genes. Cell 69:1073-1087.
38. Parr, B. A., and McMahon, A. P. (1994). Wnt genes and vertebrate development. Curr. Opin. Genet. Dev. 4: 523-528.
39. Roelink, H., and Nusse, R. (1991). Expression of two members of the Wnt family during mouse development - Restricted temporal and spatial patterns in the developing neural tube. Genes Dev. 5: 381-388.
40. Roelink, H., Wagenaar, E., Lopes da Silva, S., and Nusse, R. (1990). Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain. Proc. Natl. Acad. Sci. USA 87: 4519-4523.
41. Roelink, H., Wang, J., Black, D. M., Solomon, E., and Nusse, R. (1993). Molecular cloning and chromosomal localization to 17q21 of the human WNT-3 gene. Genomics 17: 790-792.
42. Russell, J., Gennissen, A., and Nusse, R. (1992). Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila. Development 115: 475-485.
43. Sidow, A. (1992). Diversification of the Wnt gene family on the ancestral lineage of vertebrates. Proc. Natl. Acad. Sci. USA 89: 5098-5102.
44. Smolich, B. D., McMahon, J. A., McMahon, A. P., and Papkoff, J. (1993). Wnt family proteins are secreted and associated with the cell surface. Mol. Biol. Cell 4: 1267-1275.
45. Van Leeuwen, F., Samos, C. H., and Nusse, R. (1994). Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells. Nature 368: 342-344.
46. van Ooyen, A., Kwee, V., and Nusse, R. (1985). The nucleotide sequence of the human int-1 mammary oncogene: Evolutionary conservation of coding and non-coding sequences. EMBO J. 4: 2905-2909.
47. Vider, B. Z., Zimber, A., Chastre, E., Prevot, S., Gespach, C., Estlein, D., Wolloch, Y., Tronick, S. R., Gazit, A., and Yaniv, A. (1996). Evidence for the involvement of the Wnt2 gene in human colorectal cancer. Oncogene 12: 153-158.
48. Wainwright, B. J., Scambler, P. J., Stanier, P., Watson, E. K., Bell, G., Wicking, C., Estivill, X., Courtney, M., Boue, A., Pedersen, P. S., Williamson, R., and Farrall, M. (1988). Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO J. 7: 1743-1748.
49. Walter, M., Spillet, D., Thomas, P., Weissenbach, J., and Goodfellow, P. (1994). A method for constructing radiation hybrid maps of whole genomes. Nature Genet. 7: 22-28.
50. Wolda, S. L., and Moon, R. T. (1992). Cloning and developmental expression in Xenopus laevis of seven additional members of the Wnt family. Oncogene 7: 1941-1947.
51. Wong, G. T., Gavin, B. J., and McMahon, A. P. (1994). Differential transformation of mammary epithelial cells by Wnt genes. Mol. Cell. Biol. 14: 6278-6286.
52. Zacharek, G. X., Salkowski, A., Grignon, D. J., Sakr, W., Porter, A. T., and Honn, K. V. (1995). Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer. Cancer Res. 55: 1002-1005.