Single Amino Acid Mutations in the Murine MHC Class II Aβ Cytoplasmic Domain Abrogate Antigen Presentation

Journal of Immunology

Volumn 159, Issue 12, 1997, Pages 5914-5920

  Laufer, Terri M ^a,b   Smiley, Stephen T ^a,d   Ranger, Ann ^a   Clements, Virginia K ^c   Ostrand Rosenberg, Suzanne ^c   Glimcher, Laurie H ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d Millenium   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2;

A J MOUSE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; ANTIGEN PRESENTATION; ARTICLE; B CELL LYMPHOMA; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL CULTURE; CYTOPLASM; FEMALE; GENETICS; GRAFT REJECTION; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN TERTIARY STRUCTURE; RAT; SARCOMA; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SWINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGEN PRESENTATION; CYTOPLASM; FEMALE; GRAFT REJECTION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LYMPHOMA, B-CELL; MALE; MICE; MICE, INBRED A; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEOPLASM TRANSPLANTATION; PROTEIN STRUCTURE, TERTIARY; RATS; SARCOMA, EXPERIMENTAL; SEQUENCE HOMOLOGY, AMINO ACID; SWINE; TUMOR CELLS, CULTURED;

EID: 0031573562     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Nabavi, N., Z. Ghogawala, A. Myer, I. J. Griffith, W. F. Wade, Z. Z. Chen, D. J. McKean, and L. H. Glimcher. 1989. Antigen presentation abrogated in cells expressing truncated Ia molecules. J. Immunol. 142:1444.
2. k protein. Proc. Natl. Acad. Sci. USA 86:6297.
3. St-Pierre, Y., N. Nabavi, Z. Ghogawala, L. H. Glimcher, and T. H. Watts. 1989. A functional role for signal transduction via the cytoplasmic domains of MHC class II proteins. J. Immunol. 143:808.
4. Nabavi, N., G. J. Freeman, A. Gault, D. Godfrey, L. M. Nadler, and L. H. Glimcher. 1992. Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression. Nature 360:266.
5. Watts, T. H., N. Alaverdi, W. F. Wade, and P. S. Linsley. 1993. Induction of costimulatory molecule B7 in M12 B lymphomas by cAMP or MHC-restricted T cell interaction. J Immunol. 150:2192.
6. Cambier, J. C., M. K. Newell, L. B. Justement, J. C. McGuire, K. L. Leach, and Z. Z. Chen. 1987. Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes. Nature 327:629.
7. Ostrand, R. S., A. Thakur, and V. Clements. 1990. Rejection of mouse sarcoma cells after transfection of MHC class II genes. J. Immunol. 144:4068.
8. Ostrand, R. S., C. A. Roby, and V. K. Clements. 1991. Abrogation of tumorigenicity by MHC class II antigen expression requires the cytoplasmic domain of the class II molecule. J. Immunol. 147:2419.
9. Smiley, S. T., T. M. Laufer, D. Lo, L. H. Glimcher, and M. J. Grusby. 1995. Transgenic mice expressing MHC class II molecules with truncated A β cytoplasmic domains reveal signaling-independent defects in antigen presentation. Int. Immunol. 7:665.
10. Shin, J., R. L. Dunbrack, Jr., S. Lee, and J. L. Strominger. 1991. Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4. J. Biol. Chem. 266:10658.
11. Letourneur, F., and R. D. Klausner. 1992. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell 69:1143.
12. Johnson, K. F., and S. Kornfeld. 1992. A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function. J. Biol. Chem. 267:17110.
13. Pinet, V., M. Vergelli, R. Martin, O. Bakke, and E. O. Long. 1995. Antigen presentation mediated by recycling of surface HLA-DR molecules. Nature 375: 603.
14. Glimcher, L. H., D. J. McKean, E. Choi, and J. G. Seidman. 1985. Complex regulation of class II gene expression: analysis with class II mutant cell lines. J. Immunol. 135:3542.
15. Haskins, K., C. Hannum, J. White, N. Roehm, R. Kubo, J. Kappler, and P. Marrack. 1984. The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype. J. Exp. Med. 160:452.
16. Allen, P. M., D. J. McKean, B. N. Beck, J. Sheffield, and L. H. Glimcher. 1985. Direct evidence that a class II molecule and a simple globular protein generate multiple determinants. J. Exp. Med. 162:1264.
17. k molecules allows the definition of distinct serologic epitopes on A α and A β polypeptides. J. Immunol. 136:2953.
18. Mikaelian, I., and A. Sergeant. 1992. A general and fast method to generate multiple site directed mutations. Nucleic Acids Res. 20:376.
19. Estess, P., A. B. Begovich, M. Koo, P. P. Jones, and H. O. McDevitt. 1986. Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A β cDNA clones. Proc. Natl. Acad. Sci. USA 83:3594.
20. Miller, J., and R. N. Germain. 1986. Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain. J. Exp. Med. 164: 1478.
21. Rock, K. L., and B. Benacerraf. 1983. Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers: evidence of specific competition for accessory cell antigen presentation. J. Exp. Med. 157: 1618.
22. Braunstein, N. S., and R. N. Germain. 1987. Allele-specific control of Ia molecule surface expression and conformation: implications for a general model of Ia structure-function relationships. Proc. Natl. Acad. Sci. USA 84:2921.
23. Smiley, S. T., A. Y. Rudensky, L. H. Glimcher, and M. J. Grusby. 1996. Truncation of the class II β-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes. Proc. Natl. Acad. Sci. USA 93:241.
24. Chicz, R. M., R. G. Urban, J. C. Gorga, D. A. Vignali, W. S. Lane, and J. L. Strominger. 1993. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 178:27.
25. Denzin, L. K., N. F. Robbins, C. Carboy-Newcomb, and P. Cresswell. 1994. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. Immunity 1:595.
26. Sloan, V. S., P. Cameron, G. Porter, M. Gammon, M. Amaya, E. Mellins, and D. M. Zaller. 1995. Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature 375:802.
27. Zhong, G., P. Romagnoli, and R. N. Germain. 1997. Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein. J. Exp. Med. 185:429.
28. Lindner, R., and E. R. Unanue. 1996. Distinct antigen MHC class II complexes generated by separate processing pathways. EMBO J. 15:6910.
29. Wolf, P. R., and H. L. Ploegh. 1995. How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. Annu. Rev. Cell Der. Biol. 11:267.
30. Scholl, P. R., and R. S. Geha. 1994. MHC class II signaling in B-cell activation. Immunol. Today 15:418.
31. Harton, J. A., and G. A. Bishop. 1993. Length and sequence requirements of the cytoplasmic domain of the A β molecule for class II-mediated B cell signaling. J. Immunol. 151:5282.
32. Harton, J. A., A. E. Van Hagen, and G. A. Bishop. 1995. The cytoplasmic and transmembrane domains of MHC class II β chains deliver distinct signals required for MHC class II-mediated B cell activation. Immunity 3:349.
33. Larhammar, D., U. Hammerling, M. Denaro, T. Lund, R. A. Flavell, L. Rask, and P. A. Peterson. 1983. Structure of the murine immune response I-A β locus: sequence of the I-A β gene and an adjacent β-chain second domain exon. Cell 34:179.
34. Larhammar, D., J. J. Hyldig-Nielsen, B. Servenius, G. Andersson, L. Rask, and P. A. Peterson. 1983. Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC β gene. Proc. Natl. Acad. Sci. USA 80:7313.
35. Syha-Jedelhauser, J., U. Wendling, and K. Reske. 1991. Complete coding nucleotide sequence of cDNA for the class II RT1.B β I chain of the Lewis rat. Biochim. Biophys. Acta 1089:414.
36. Saito, H., R. A. Maki, L. K. Clayton, and S. Tonegawa. 1983. Complete primary structures of the E β chain and gene of the mouse major histocompatibility complex. Proc. Natl. Acad Sci. USA 80:5520.
37. Gustafsson, K., K. Wiman, E. Emmoth, D. Larhammar, J. Bohme, J. J. Hyldig-Nielsen, H. Ronne, P. A. Peterson, and L. Rask. 1984. Mutations and selection in the generation of class II histocompatibility antigen polymorphism. EMBO J. 3:1655.
38. Robertson, K. A., and W. R. McMaster. 1985. Complete structure of a rat RT1 E β chain: extensive conservation of MHC class II beta chains. J. Immunol. 135:4095.
39. Gustafsson, K., C. LeGuern, F. Hirsch, S. Germana, K. Pratt, and D. H. Sachs. 1990. Class II genes of miniature swine. IV. Characterization and expression of two allelic class II DQB cDNA clones. J. Immunol. 145:1946.