Formulation Development and Primary Degradation Pathways for Recombinant Human Nerve Growth Factor

Analytical Chemistry

Volumn 69, Issue 20, 1997, Pages 4184-4190

  Eng, Marian ^a   Ling, Victor ^a   Briggs, Jonathan A ^a,b   Souza, Karen ^a   Canova Davis, Eleanor ^a   Powell, Michael F ^a   De Young, Linda R ^a,c  

^a GENENTECH INC   (United States)

^b NEKTAR THERAPEUTICS   (United States)

^c AeroGen Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NERVE GROWTH FACTOR; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMISTRY; CHO CELL; HAMSTER; HUMAN; METABOLISM; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; RECOMBINANT PROTEINS;

EID: 0031572520     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac9704016     Document Type: Article

References (24)

1. Hefti, F. J. Neurobiol. 1994, 25, 1418-1435.
2. Levi-Montalcini, R. Science 1987, 237, 1154-1162.
3. Apfel, S. C.; Lipton, R. B.; Arezzo, J. C.; Kessler, J. A. Neurology 1991, 28, 87-90.
4. Apfel, S. C.; Arezzo, J. C.; Lipson, L. A.; Kessler, J. A. Ann. Neurol. 1992, 31, 76-80.
5. McDonald, N. Q.; Lapatto, R.; Murray-Rust, J.; Gunning, J.; Wlodawer, A.; Blundell, T. L. Nature 1991, 354, 411-414.
6. Bothwell, M. A.; Shooter, E. M. J. Biol. Chem. 1977, 252, 8532-8536.
7. Timm, D. E.; de Haseth, P. L.; Neet, K. E. Biochemistry 1994, 33, 4667-4676.
8. Schmelzer, C. H.; Burton, L. E.; Chan, W.-P.; Martin, E.; Gorman, C.; Canova-Davis, E.; Ling, V. T.; Sliwkowski, M. B.; McCray, G.; Briggs, J. A.; Nguyen, T. H.; Polastri, G. J. Neurochem. 1992, 59, 1675-1683.
9. Geiger, R.; Clarke, S. J. Biol. Chem. 1987, 262, 785-794.
10. Manning, M. C.; Patel, K.; Borchardt, R. T. Pharm. Res. 1989, 6, 903-918.
11. Greene, L. A. Brain Res. 1997, 133, 350-353.
12. Reed, K.; Yalkowsky, S. J. Parenter. Sci. Technol. 1987, 41, 37-39.
13. Timm, D. E.; Neet, K. E. Protein Sci. 1992, 1, 236-244.
14. Moore, J. B.; Shooter, E. M. Neurobiology 1975, 5, 369-381.
15. Canova-Davis, E.; Ling, V.; Eng, M.; Skieresz, S. Peptides: Chemistry, Structure and Biology ; Escom Science Publishers: Leiden, The Netherlands, 1993; pp 230-231.
16. De Young, L. R.; Briggs, J. A.; Powell, M. F. Biophys. J. 1994, 66, A401.
17. Brot, N.; Weissbach, H. Trends Biochem. Sci. 1982, 7, 137-139.
18. Teshima, G.; Canova-Davis, E. J. Chromatog. 1992, 625, 207-215.
19. Cleland, J. L.; Powell, M. F.; Shire, S. J. Crit. Rev. Therap. Drug Carr. Syst. 1993, 10, 307-377.
20. Ullrich, A.; Gray, A.; Berman, C.; Dull, T. J. Nature 1983, 303, 821-825.
21. Smyth, D. G.; Stein, W. H.; Moore, S. J. Biol Chem. 1962, 237, 1845-1850.
22. Stephenson, R. C.; Clarke, S. J. Biol. Chem. 1989, 264, 6164-6170.
23. Bodansky, M.; Kwei, J. Z. Int. J. Pept. Protein Res. 1978, 12, 69-74.
24. Geiger, T.; Clarke, S. J. Biol. Chem. 1987, 262, 785-794.