The transplantation of hematopoietic stem cells. Part I: Definitions, application, complications;Die transplantation hamatopoetischer stammzellen. Teil I: Definitionen, prinzipielle anwendungs - Moglichkeiten, komplikationen

Medizinische Klinik

Volumn 92, Issue 8, 1997, Pages 480-491

  Link, Hartmut ^a   Kolb, Hans Jochem ^b   Ebell, Wolfram ^c   Hossfeld, Dieter Kurt ^d   Zander, Axel ^d   Niethammer, Dietrich ^e   Wandt, Hannes ^f   Grosse Wilde, Hans ^g   Schaefer, Ulrich W ^h  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d UNIVERSITY OF HAMBURG   (Germany)

^e UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^f Inst fur Hamatologie und Onkologie   (Germany)

^g UNIVERSITY HOSPITAL ESSEN   (Germany)

^h Klin F Knochenniarktransplantation   (Germany)

Author keywords

Application; Complications; Definitions; Hematopietic stem cells; Transplantation

Indexed keywords

AUTOTRANSPLANTATION; BONE MARROW CELL; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL; HLA TYPING; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; REVIEW; STEM CELL TRANSPLANTATION; ALLOTRANSPLANTATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LEUKEMIA; NEOPLASM;

GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA; NEOPLASMS; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0031571348     PISSN: 07235003     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03044917     Document Type: Review

References (107)

1. Agematsu K., F. Kitahara, Y Uehara, H. Kawai, Y. Miyagawa, A. Komiyama, Y. Nakahori, Y. Nakagome, T. Akabane Detection of engraftment and chimerism after bone marrow transplantation by in situ hybridization using a Y-chromosome specific probe. Amer. J. Hemat 33 (1990), 255-260.
2. Anasetti, C., D. Amos, P G. Beatty, F. R. Appelbaum, W. Bensinger, C. D. Buckner, R. Clift, K. Doney, P J. Martin, E Mickelson, B. Nisperos, J. O'Quigley, R. Ramberg, J E. Sanders, P. Stewart, R. Storb, K. M. Sullivan, R. P, Witherspoon, E D. Thomas, J. A Hansen: Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma New Engl. J. Med 320 (1989), 197-204
3. Andrews, R G ,J. W. Singer, I. D. Bernstein; Monoclonal antibody 12-8 recognizes a 115-kd molecule present on both unipotent and multipotent hematopoietic colony-forming cells and their precursors Blood 67 (1986), 842-845.
4. Apperley, J. F., F. R. Mauro, J. M. Goldman, W. Gregory, C. K. Arthur, J. Hows, W. Arcese, G. Papa, F. Mandelli, D Wardle, P Gravett, I M. Franklin, G Bandini, P. Ricci, S. Tura, A Iacone, G. Torlontano, W. Heit, R. Champlin, R. P. Gale: Bone marrow transplantation for chronic myeloid leukaemia in first chronic phase importance of a graft-versus-leukaemia effect. Brit. J. Haemat. 69 (1988), 239-245.
5. Armitage, J. O.: Treatment of non-Hodgkin's lymphoma New Engl. J. Med. 328 (1993), 1023-1030.
6. Armitage, J O.: Bone marrow transplantation. New Engl. J Med. 330 (1994), 827-838.
7. Atkinson, K., M. M. Horowitz, R P. Gale, D. W. van Bekkum, E. Gluckman, R. A. Good, N. Jacobsen, H.-J. Kolb. A. A. Rimm, O. Ringdén, C. Rozman, K. A. Sobocinski, F E. Zwaan, M M Bortin: Risk factors for chronic graft-versus-host disease after HLA-identical sibling bone marrow transplantation. Blood 75 (1990), 2459-2464
8. Baum, C M., I L. Weissman, A S Tsukamoto, A M. Buckle, B. Peault. Isolation of a candidate human hematopoietic stem-cell population. Proc. nat. Acad. Sci. (Wash.) 89 (1992), 2804-2808
9. Bearman, S I.: The syndrome of hepatic veno-occlusive disease after marrow transplantation. Blood 85 (1995), 3005-3020.
10. Bearman, S. I , F. R Appelbaum, A. Back, F. B. Petersen, C. D. Buckner, K. M Sullivan, H G. Schoch, L. D. Fisher, E. D Thomas: Regimen-related toxicity and early posttransplant survival in patients undergoing marrow transplantation for lymphoma. J. clin. Oncol. 7 (1989), 1288-1294.
11. Bearman S I., F. R Appelbaum, C. D. Buckner, F B. Petersen, L. D. Fisher, R. A Clift, E. D Thomas: Regimen-related toxicity in patients undergoing bone marrow transplantation. J. clin Oncol. 6 (1988), 1562-1568.
12. Beelen, D W., E. Haralarnbie, H. Brandt, G. Linzenineier, K. D Muller, K. Quabeck, H. G. Sayer, U Graeven, H. K. Mahmoud, U. W. Schaefer: Evidence that sustained growth suppression of intestinal anaerobic bacteria reduces the risk of acute graft-versus-host disease after sibling marrow transplantation Blood 80 (1992), 2668-2676.
13. Bender, J G., K. L Unverzagt, D. E Walker, W. Lee, D E Van Epps, D. H Smith, C. C. Stewarr, L. B. To: Identification and comparison ofCD34-positive cells and their subpopulations from normal peripheral blood and bone marrow using multicolor flow cytometry. Blood 77 (1991), 2591-2596.
14. Bemhard, H , M. L. Disis, S. Heimfeld, S. Hand, J. R. Gralow, M A Cheever. Generation of immunostimulatory dendritic cells from human CD34+ hematopoietic progenitor cells of the bone marrow and peripheral blood. Cancer Res 55 (1995), 1099-1104
15. Boeckh, M., R A. Bowden, J M Goodrich, M Pettinger, J. D Meyers Cytomegalovirus antigen detection in peripheral blood leukocytes after allogeneic marrow transplantation. Blood 80 (1992), 1358-1364.
16. Bordignon, C., C. A. Keever, T. N. Small, N. Flomenberg, B. Dupont, R. J. O'Reilly, N. A. Kernan: Graft failure after T-cell-depleted human leukocyte antigen identical marrow transplants for leukemia; II. In vitro analyses of host effector mechanisms. Blood 74 (1989), 2237-2243.
17. Buckner, C. D , R. A. Clift, J. E. Sanders, P. Stewart, W. I. Bensinger, K. C. Doney, K. M. Sullivan, R. P. Witherspoon, H. J. Deeg, F. R. Appelbaum et al.: Marrow harvesting from normal donors. Blood 64 (1984), 630-634.
18. Busca, A., C. Anasetti, G. Anderson, F. R. Appelbaum, C. D. Buckner, K Doney, P. J. Martin, E. Petersdorf, J. E. Sanders, J. A. Hansen: Unrelated donor or autologous marrow transplantation for treatment of acute leukemia. Blood 83 (1994), 3077-3084.
19. Chao, N. J., G. M. Schmidt, J C. Niland, M. D. Amylon, A. C. Dagis, G. D. Long, A. P. Nademanee, R. S Negrin, M. R. O'Donnell, P. M. Parker et al.: Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophylaxis of acute graft-versus-host disease. New Engl. J. Med. 329 (1993), 1225-1230.
20. Craig, W., R. Kay, R. L. Cutler, P. M. Lansdorp: Expression of Thy-1 on human hematopoietic progenitor cells. J. exp. Med. 177 (1993), 1331-1342.
21. De Witte, T., A. Gratwohl, N. Van Der Lely, A. Bacigalupo, A. C. Stem, B. Speck, A. Schartenberg, C. Nissen, E. Gluckman, W. E. Fibbe; Recombinant human granulocyte-macrophage colony stimulating factor accelerates neutrophil and monocyte recovery after allogeneic T-cell-depleted bone marrow transplantation. Blood 79 (1992), 1359-1365.
22. Deeg, H. J : Delayed complications and long term effects after bone marrow transplantation. Hemat. Oncol. Clin. N. Amer. 4 (1991), 641-657.
23. Dopfer, R., D. Niethammer: Report on the international workshop of the Kind Philipp Foundation on late effects after bone marrow transplantation in childhood malignancies. Pediat. Hemat. Oncol. 10 (1993), 63-84.
24. Einsele, H., G. Ehninger, M. Steidle, A. Vallbracht, M. Muller, H. Schmidt, J G. Saal, H. D. Waller, C. A. Muller: Polymerase chain reaction to evaluate antiviral therapy for cytomegalovirus disease. Lancet 338 (1991), 1170-1172.
25. Emminger, W , W. Emminger-Schmidmeier, P. Hocker, R. Hawliczek, C. Peters, J Pawlowsky, G. Neuwirth, M Kummer, H. Gadner: Autologous peripheral stem cell transplantation in children. Klin. Pädiat. 201 (1989), 299-303.
26. Ferrara, J. L., H. J. Deeg: Graft-versus-host disease. New Engl. J. Med. 324 (1991), 667-674.
27. Forman, S. J., K. G. Blume, E. D. Thomas: Bone marrow transplantation. Blackwell Scientific Publications, Boston 1994.
28. Forman, S J , J. A Zaia: Treatment and prevention of cytomegalovirus pneumonia after bone marrow transplantation. Where do we stand? Blood 83 (1994), 2392-2398.
29. Gale, R. P., M. M. Bortin, D. W. van Bekkum, J. C. Biggs, K. A. Dicke, E. Gluckman, R. A Good, R G. Hoffmann, H. E M Kay, J. H. Kersey, A. M. Marmont, T. Masaoka, A. A. Rimm, J. J. van Rood, F. E. Zwaan: Risk factors for acute graft-versus-host disease. Brit. J. Haemat. 67 (1987), 397-406.
30. Gale, R. P., R. S. Sparkes, D. W. Golde: Bone marrow origin of hepatic macrophages. Science 201 (1978), 937-938.
31. Giorgiani, G., M Bozzola, F. Locatelli, P Picco, M. Zecca, M. Cisternino, S. Dallorso, F. Bonetti, G. Dint, C. Borrone, M. B. Regazzi, P. De Stefano, F. Severi: Role of busulfan and total body irradiation on growth of prepubertal children receiving bone marrow transplantation and results of treatment with recombinant human growth hormone. Blood 86 (1995), 825-831.
32. Gisselbrecht, C., H. G. Prentice, A. Bacigalupo, P. Biron, N. Milpied, H Rubie, D Cunningham, M. Legros, J. L. Pico, D C. Linch, A. K. Burnett, J. H. Scarffe, W. Siegert, A. Yver: Placebo-controlled phase III trial of lenograstim in bone-marrow transplantation. Lancet 343 (1994), 696-700.
33. Glucksberg, H., R Storb, A Fefer, C D. Buckner, P. E. Neiman, R. A. Clift, K. G Lerner, E. D. Thomas. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation 18 (1974), 295-304.
34. Goldman, J. M., J. F Apperley, L. Jones, R. Marcus, A. W. Goolden, R. Batchelor, G. Hale, H. Waldman, C. D. Reid, J. Hows, E. Gordon-Smith, D. Catovsky, D. A. Galton: Bone marrow transplantation for patients with chronic myeloid leukemia. New Engl. J Med. 314 (1986), 202-207.
35. Goldman, J M., R. P. Gale, M M. Horowitz, J. C. Biggs, R. E. Champlin, E Gluckman, R. G. Hoffmann, S. J. Jacobsen, A. M. Marmont, P B. McGlave, H. A. Messner, A. A. Rimm, C. Rozman, B. Speck, S. Tura, R. S. Weiner, M M. Bortin: Bone marrow transplantation for chronic myelogenous leukemia in chronic phase: Increased risk for relapse associated with T-cell depletion Ann. intern. Med 108 (1988), 806-814.
36. Goulmy, E., R. Schipper, J Pool, E Blokland, J. H. F. Falkenburg, J. Vossen, A. Gratwohl, G B. Vogelsang, H. C. Van Houwelingen, J. J. van Rood: Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation New Engl. J. Med. 334 (1996), 281-285.
37. Gratwohl, A., J. Hermans, J. Apperley, W. Arcese, A Bacigalupo, G. Bandini, P. Di Bartolomeo, M. Boogaerts, A. Bosi, E. Carreras, A. Devergie, A. Ferrant, W. E. Fibbe, F. Frassom, G. Gahrton, J. Goldman, A. Iriondo, N. Jacobsen, H. J. Kolb, H. Link, M. Michallet, H. G. Prentice, J. Reiffers, F. V Rhee: Acute graft-versus-host disease: Grade and outcome in patients with chronic myelogenous leukemia. Blood 86 (1995), 813- 818.
38. Horowitz, M. M., R. P. Gale, P. M. Sondel, J. M Goldman, J. Kersey, H.-J. Kolb, A. A Rimm, O. Ringdén, C. Rozman, B. Speck, R. L. Truitt, F. E. Zwaan, M. M. Bortin: Graft-versus-leukemia reactions after bone marrow transplantation. Blood 75 (1990), 555-562.
39. Huang, S., L. W. Terstappen: Formation of haematopoietic microenvironment and haematopoietic stem cells from single human bone marrow stem cells. Nature (Lond.) 360 (1992), 745-749.
40. Hubner, G., K. Battmer, U. Paaz, H Link: Monitoring of relapse and remission in acute leukemias by DNA-finger-print analysis Brit J. Haematol. 85 (1993), 320- 325
41. Jin, N. R , R. S Hill, F B. Petersen, C. D. Buckner, P. S. Stewart, D. Amos, F R. Appelbaum, R. A. Clift, W. I. Bensinger, J. E Sanders, K. C. Doney, K. M. Sullivan, R. P Witherspoon, H. J. Deeg, R Storb, R. Livingston, R. Chard, E. D. Thomas: Marrow harvesting for autologous marrow transplantation. Exp. Hemat. 13 (1985), 879-884.
42. Jones, R J., R. F. Ambinder, S. Piantadosi, G. W. Santos: Evidence of a graft-versus-lymphoma effect associated with allogeneic bone marrow transplantation. Blood 77 (1991), 649-653.
43. Kernan, N. A , G. Bartsch, R. Ash, P G. Beatty, R. Champlin, A. Filipovich, J. Gajewski, J. A. Harisen, J. Henslee-Downey, J. McCullough, P. McGlave, H A. Perkins, G L. Phillips, J. Sanders, D Stroncek, E D. Thomas, K. G. Blume: Analysis of 462 transplantations from unrelated donors facilitated by the national marrow donor program. New Engl J. Med 328 (1993), 593-602.
44. Keman, N. A., C. Bordignon, G. Heller, I. Cunningham, H. Castro-Malaspina, B Shank, N. Flomenberg, J. Burns, S. Y. Yang, P. Black, N. H. Collins, R. J. O'Reilly: Graft failure after T-cell-depleted human leukocyte antigen identical marrow transplants for leukemia I. Analysis of risk factors and results of secondary transplants. Blood 74 (1989), 2227-2236.
45. Keman, N. A., N. H. Collins, L. Juliano, T. Cartagena, B. Dupont, R. J O'Reilly: Clonable T lymphocytes in T cell-depleted bone marrow transplants correlate with development of graft-v-host disease. Blood 68 (1986), 770-773.
46. Keman, N. A , B. Dupont: Minor histocompatibility antigens and marrow transplantation. New Engl. J. Med. 334 (1996), 323-324
47. Körbling, M., D Przepiorka, K Van Besien, S Giralt, B. Andersson, Y. O. Huh, H. D. Kleine, D. Seong, A. B Deisseroth, M. Andreeff, R Champlin: Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: potential advantage of blood over marrow allografts. Blood 85 (1995), 1659-1665.
48. Krall, W. J., P. M. Challita, L. S. Perlmutter, D. C. Skelton, D. B Kohn Cells expressing human glucoce-rebrosidase from a retroviral vector repopulate macrophages and central aervous system microglia after murine bone marrow transplantation. Blood 83 (1994), 2737-2748.
49. Krause, D. S., M. J. Fackler, C. I. Civin, W. S May: CD34: structure, biology, and and clinical utility. Blood 87 (1996), 1-13.
50. 49a Kurtzberg, J., M. Laughlin, M. L. Graham, C. Smith, J. F. Olson, E. C. Halperin, G. Ciocci, C. Carrier, C. E. Stevens, P. Rubinstein: Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N. Engl. J. Med 335 (1996), 157-166.
51. Lane, T. A., P. Law, M Maruyama, D. Young, D. Burgess, M. Mullen, M. Mealiffe, L. W. M M. Terstappen, A. Hardwick, M. Moubayaed, F. Oldham, R. E. T. Corringham, A. D. Ho: Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by granulocyte-macrophage colony stimulating factor (GM-CSF) or G-CSF: Potential role in allogencic marrow transplantation. Blood 85 (1995), 275-282.
52. Lee, M. Y., J. L Lousfeldt, K. L. Fevold: Identification and characterization of osteoclast progenitors by clonal analysis of hematopoietic cells. Blood 80 (1992), 1710-1716.
53. Link, H., L. Arseniev, O. Bahre, R J. Berenson, K. Battmer, J. Kadar, R Jacobs, J Casper, J. Kühl, J. Schubert, H. Diedrich, H. Poliwoda: Combined transplantation of allogeneic bone marrow and CD34+ blood cells. Blood 86 (1995), 2500-2508.
54. Link, H , L Arseniev, o. Bahre, J. Kadar, H. Diedrich, H. Poliwoda: Transplantation of allogeneic CD34+ blood cells. Blood 87 (1996), 4903-4909.
55. Link, H , K. Battmer, H. Kugland, L. Arseniev, D. Kleine: Cytomegalievirusinfektion Pathophysiologie, moderne Nachweismethoden und Therapie beim immunsupprimierten Patienten. Z. Tox Med. 2 (1990), 11-22
56. Link, H., M. Boogaerts, A. A. Fauser, S. Slavin, J. Reiffers, N. C. Gorin, A. M. Carella, F. Mandelli, S. Burdach, A. Ferrant, W. Linkesch, S. Tura, A. Bacigalupo, F. Schindel, H. Heinrichs: A controlled trial of recombinant human erythropoietin after bone marrow transplantation. Blood 84 (1994), 3327-3335.
57. Link, H., M A. Boogaerts, A. M. Carella, A. Ferrant, H. Gadner, N. C. Gorin, I. Harabacz, J. L. Harousseau, P. Hervé, J. Holldack, H. J. Kolb, O. Krieger, B. Labar, W. Linkesch, F. Mandelli, D. Maraninchi, E. Naparstek, U. Nicolay, D. Niederwieser, J. Reiffers, V. Rizzoli, W. Siegert, J. P. Vernant, T. De Witte: A controlled trial of recombinant human granulocyte-macrophage colony stimulating factor after total body irradiation, high dose chemotherapy and autologous bone marrow transplantation for acute lymphoblastic leukemia or malignant lymphoma. Blood 80 (1992), 2188-2195
58. Link, H , G. Hübner, C. Meyer, M. Freund, B. Schneider, H Wandt, P. Schonrock-Nabulsi, M. Gramatzki, W. Queisser, E. Fackler-Schwalbe, B. Löffler, M. Raab, S Öhl, U. Brack, S. Gabius, G. Ehninger. Prospective comparative trial of postremission therapy in adult patients with acute myeloblastic leukemia: high dose cytosine arabinosíde versus allogeneic and unpurged autologous bone marrow transplantation. Blood 80, Suppl. 10 (1992), 114a.
59. Link, H., H. J. Kolb, D. Niethammer, D. K. Hossfeld, B. Kubanek, H. Heimpel: Voraussetzungen für die Transplantation von hamatopoetischen Stammzellen. Dtsch. Ärztebl. 91 (1994), A 2592-2594.
60. Link, H., U. Reinhard, E Walter, P. Wernet, E. M. Schneider, H Fischbach, M. Blaurock, K. Wilms, D. Niethammer, P Ostendorf Lung diseases after bone marrow transplantation. A study of clinic, radiology, histology, lung function and immunology. Klin. Wschr. 64 (1986), 595-614
61. Ljungman, P., P Biron, A. Bosi, J. Y. Cahn, A. H. Goldstone, N.-C. Gorin, H. Link, C. Messina, M. Michallet, C Richard, L. Verdonck: Cytomegalovirus interstitial pneumonia in autologous bone marrow transplant recipients Bone Marrow Transplant. 13 (1994), 209-212.
62. Ljungman, P., C. Cordonnier, R. De Bock, H. Einsele, D. Engelhard, J. Grundy, H. Link, A. Locasciulli, G. Prentice, P. Reusser, P, Ribaud Immunisations after bone marrow transplantation: results of a European survey and recommendations from the infectious diseases working party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant. 15 (1995), 455-460
63. Ljungman, P., D. Engelhard, H. Link, P. Biron, L. Brandt, S. Brunet, C. Cordonnier, L. Debusscher, A de Laurenzi, H. J. Kolb, C Messina, A. C. Newland, H. G. Prentice, C Richard, T Ruutu, T. Tilg, L Verdonck: Treatment of interstital pneumonitis due to cytomegalovirus with ganciclovir and intravenous immune globulin: Experience of European bone marrow transplant group Clin. infect. Dis. 14 (1992), 831-835.
64. Lowenthal, R. M., M. L. Cohen, K. Atkinson, J. C. Biggs: Apparent cure of rheumatoid arthritis by bone marrow transplantation. J Rheum. 20 (1993), 137-140.
65. Maraninchi, D., D Biaise, B. Rio, V. Leblond, F. Dreyfus, E Gluckman, D. Guyotat, J. L. Pico, M Michallet, N. Ifrah: Impact of T-cell depletion on outcome of allogeneic bone marrow transplantation for standard-risk leukaemias Lancet II (1987), 175-178.
66. McDonald, G. B., M. S. Hinds, L. D. Fisher, H. G. Schoch, J. L Wolford, M. Banaji, B. J Hardin, H. M. Shulman, R A. Clift: Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann. intern. Med. 118 (1993), 255-267.
67. McGlave, P. B., P. De Fabritiis, A. Deisseroth, J. Goldman, M. Barnett, J. Reiffers, B. Simonsson, A. Carella, D Aeppli: Autologous transplants for chronic myelogenous leukaemia: Results from eight transplant groups Lancet 343 (1994), 1486-1488.
68. Meyers, J D.: Infection in bone marrow transplant recipients. Amer. J. Med. 81, Suppl. 1A (1986), 27-38.
69. Meyers, J. D., N. Flournoy, E. D. Thomas. Risk factors for cytomegalovirus infection after human marrow transplantation. J. infect Dis. 153 (1986), 478-488.
70. Miller, J. S., D. C. Arthur, C. E. Litz, J. P Neglia, W. J. Miller, D J. Weisdorf; Myelodysplastic syndrome after autologous bone marrow transplantation an additional late complication of curative cancer therapy. Blood 83 (1994), 3780-3786.
71. Nademanee, A , G. M. Schmidt, P. Parker, A. C. Dagis, A. Stein, D. S. Snyder, M. O'Donnell, E. P. Smith, D. E. Stepan, A. Molina, K. K. Wong, K. Margolin, G. Somlo, B. Littrell, D. Woo, I Sniecinski, J. C. Niland, S. J. Forman. The outcome of matched unrelated donor bone marrow transplantation in patients with hematologic malignancies using molecular typing for donor selection and graft-versus-host disease prophylaxis regimen of cyclosporine, methotrexate, and prednisone. Blood 86 (1995), 1228-1234.
72. Nash, R. A , M. S Pepe, R. Storb, G. Longton, M. Pettinger, C. Anasetti, F. R. Appelbaum, R A. Bowden, H J. Deeg, K. Doney et al.: Acute graft-versus-host disease: analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexatc. Blood 80 (1992), 1838-1845.
73. Nimer, S. D., J Giorgi, J. L Gajewski, N. Ku, G. J. Schiller, K Lee, M. Temto, W Ho, S. Feig, M. Selch, V. Isacescu, T. A. Reichert, R. E Champlin: Selective depletion of CD8+ cells for prevention of graft-versus-host disease after bone marrow transplantation: A randomized controlled trial. Transplantation 57 (1994), 82-87.
74. Ochs, L., X. O Shu, J. Miller, H. Enright, J. Wagner, A. Filipovich, W. Miller, D. Weisdorf: Late infections after allogeneic bone marrow transplantation: Comparison of incidence in related and unrelated donor transplant recipients. Blood 86 (1995), 3979-3986.
75. Ochs, L. A., W. J. Miller, A. H Filipovich, R. J. Haake, P. B. McGlave, B R Blazar, N K. C. Ramsay, J. H. Kersey, D. J Weisdorf: Predictive factors for chronic graft-versus-host disease after histocompatible sibling donor bone marrow transplantation. Bone Marrow Transplant. 13 (1994), 455-460.
76. Ottinger, H , M Grosse-Wilde, A. Schmitz, H Grosse-Wilde: Knochenmarkspendersuche, Strategien - Erfolgsquoten - Kosten. Dtsch. Arztebl. 91 (1994), 420-426.
77. Ottinger, H., M. Grosse-Wilde, A. Schmitz, H. Grosse-Wilde: immunogenetic marrow donor search for 1012 patients: a retrospective analysis of strategies, outcome and costs. Bone Marrow Transplant. 14 (1994), S34- S38.
78. Ottinger, H., R. Schulze Rath, A Schmitz, H. Grosse Wilde Progress of unrelated bone marrow donor search at the University Hospital of Essen (1991-1994). Ann. Hemat 71 (1995), 71-75.
79. Pettengell, R., N. G. Testa, R. Swindell, D. Crowther, T. M. Dexter Transplantation potential of hematopoietic cells released into the circulation during routine chemotherapy for non-Hodgkin's lymphoma. Blood 82 (1993), 2239-2248.
80. Przepiorka, D , D. Weisdorf, P. Martin, H -G. Klingemann, P. Beatty, J. Hows, E D. Thomas: Meeting report: Consensus conference on acute GVHD grading. Bone Marrow Transplant. 15 (1995), 825-828.
81. Rodt, H., B. Netzel, H. J. Kolb, R. J Haas, K. Wilms, C. Bender-Götze, P. Wernet, G. Janka, H. Link: Knochenmarktransplantation bei akuter Leukämie: Prophylaktische Antiserumbehandlung des Knochenmarkes zur Unterdrückung einer Transplantat-gegen-Wirt-Reaktion. Blut 43 (1981), 113-118.
82. Rowe, J. M., N. Ciobanu, J. Ascensao, E. A. Stadtmauer, R. S. Weiner, D P Schenkein, P. McGlave, H M. Lazarus, Eastern Cooperative Oncology Group: Recommended guidelines for the management of autologous and allogeneic bone marrow transplantation: A report from the Eastern Cooperative Oncology Group (ECOG). Ann intern Med. 120 (1994), 143-158
83. Santos, G W., A D. Hess, G. B. Vogelsang: Graft versus host reactions and disease. In. Möller, G.: Graft versus host reaction; Immunological Reviews 88. Munksgaard, Copenhagen 1985, p 167-192.
84. Schmidt, G. M., D. A. Horak, J. C. Niland, S R. Duncan, S J. Forman, J. A Zaia: A randomized, controlled trial of prophylactic ganciclovir for cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplants; The City of Hope-Stanford-Syntex CMV Study Group New Engl. J. Med. 324 (1991), 1005-1011.
85. Schmitz, N , P. Dreger, M. Suttorp, E. B. Rohwedder, T. Haferlach, H. Löffler, A Hunter, N. H. Russell: Primary transplantation of allogeneic peripheral blood progenitor cells mobilised by filgrastim (granulocyte colony stimulating factor). Blood 85 (1995), 1666-1672.
86. Schmitz, N., D. C. Linch, P. Dreger, A. H Goldstone, M. A. Boogaerts, A. Ferrant, H. M. S. Demuynck, H. Link, A. Zander, A. Barge, K. M. Borkett: Randomised trial of filgrastim-mobilised peripheral blood progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patients. Lancet 347 (1996), 353-357.
87. Sheridan, W. P., C. G. Begley, C A. Juttner, J. Szer, L. B. To, D. Maher, K. McGrath, G. Morstyn, R. M. Fox: Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy Lancet 339 (1992), 640-644.
88. Shulman, H. M., K. M. Sullivan, P. L Weiden, G. B. McDonald, G. E. Striker, G. E. Sale, T. Hackman, M. S Tsoi, R. Storb, E. D. Thomas. Chronie graft versus host syndrome in man, a long-term clinicopathologic study of 20 Seattle patients. Amer. J. Med. 69 (1980), 204-217.
89. Siena, S., M. Bregni, B. Brando, N Belli, F. Ravagnani, L. Gandola, A. C Stern, P. M. Lansdorp, G. Bonadonna, A. M. Gianni: Flow cytometry for clinical estimation of circulating hematopoietic progenitors for autologous transplantation in cancer patients. Blood 77 (1991), 400-409.
90. Soiffer, R. J., C. Murray, P. Manch, K. C. Anderson, A. S. Freedman, S N. Rabinowe, T Takvonan, M J. Robertson, N. Spector, R. Gomn, K. B. Miller, R. A Rudders, A. Freeman, K. Blake, F. Coral, L Nadler, J. Ritz. Prevention of graft-versus-host disease by selective depletion of CD6-positive T lymphocytes from donor bone marrow. J. clin. Oncol. 10 (1992), 1191-1200.
91. Storb, R., H J Deeg, M Pepe, F Appelbaum, C. Anasetti, P. Beatty, W Bensinger, R. Berenson, C. D Buckner, R Clift, K. Doney, G. Longton, J. Hansen, R. Hill, T. Loughran Jr, P Martin, J. Singer, J. Sanders, P. Stewart, K. Sullivan, R Witherspoon, E D Thomas. Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: Long-term follow-up of a controlled trial Blood 73 (1989), 1729-1734.
92. Storb, R , M Pepe, C. Anasetti, F. R. Appelbaum, P. Beatty, K Doney, P. Martin P Stewart, K. M. Sullivan, R. Witherspoon, W. Bensinger, C D Buckner, R. Clift, J. Hansen, G. Longton, T. Loughran, F. B Petersen, J Singer, J. Sanders, E. D Thomas: What role for prednisone in prevention of acute graft-versus-host disease in patients undergoing marrow transplants. Blood 76 (1990), 1037-1045.
93. Sullivan, K. M., H. J Deeg, J. E. Sanders, A. Klosterman, D Amos, H Shulman, G. E. Sale, P. Martin, R. P. Witherspoon, F. R Appelbaum, K. Doney, P Stewart, J. Meyers, G B. McDonald, P Weiden, A Fefer, C. D. Buckner, R Storb, E. D. Thomas: Hyperacute graft-v-host disease in patients not given immunosuppression after allogeneic marrow transplantation. Blood 67 (1986), 1172-1175
94. Sullivan, K. M., P. L. Weiden, R. Storb, R. P. Witherspoon, A. Fefer, L. Fisher, C. D. Buckner, C Anasetti, F. R. Appelbaum, C. Badger, P. Beatty, W. Bensinger, R. Berenson, C. Bigelow, M. A. Cheever, R. Clift, H. J. Deeg, K. Doney, P. Greenberg, J. A. Hansen, R. Hill, T. Loughran, P. Martin, P Neiman: Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia. Blood 73 (1989), 1720-1728.
95. Takaue, Y., Y. Kawano, T. Abe, Y. Okamoto, T. Suzue, T. Shimizu, S Saito, J. Sato, A. Makimoto, R. Nakagawa, T Watanabe, M. Ito, Y. Kuroda: Collection and transplantation of peripheral blood stem cells in very small children weighing 20 kg or less. Blood 86 (1995), 372-380.
96. Thomas, E. D., R. E. Ramberg, G. E. Sale: Direct evidence for a bone marrow origin of the alveolar macrophage in man. Science 192 (1976), 1016-1018.
97. Thomas, E. D., R. Storb, R. A. Clift, A. Fefer, F. L. Johnson, P. E. Neiman, K. G. Lerner, H. Glucksberg, C. D. Buckner: Bone marrow transplantation (2nd of two parts). New Engl. J. Med. 292 (1975), 895-902.
98. Thomas, E. D., R. Storb, R. A. Clift, A. Fefet, F. L. Johnson, P. E. Neiman, K. G. Lerner, H. Glucksberg, C. D. Buckner: Bone marrow transplantation (1st of two parts). New Engl. J. Med. 292 (1975), 832-843.
99. van der Meer, J. W. M., H. F. L. Guiot, P. J. van den Broek, R. van Furth: Infections in bone marrow transplant recipients. Semin. Hemat. 21 (1984), 123-140.
100. van Leeuwen, J. E., M. J. van Tol, A. M. Joosten, P. T. Schellekens, R L. van den Bergh, J. L. Waaijer, N. J. Oudeman Gruber, C. P. van der Weijden Ragas, M. T. Roos, E. J. Gerritsen et al.: Relationship between patterns of engraftment in peripheral blood and immune reconstitution after allogeneic bone marrow transplantation for (severe) combined immunodeficiency. Blood 84 (1994), 3936-3947.
101. Verdonck, L. F., A. W. Dekker, G. C. de Gast, M. L. van Kempen, H. M. Lokhorst, H. K. Nieuwenhuis: Allogeneic bone marrow transplantation with a fixed low number of T cells in the marrow graft. Blood 83 (1994), 3090-3096.
102. Vogelsang, G. B., E R. Farmer, A. D. Hess, V. Altamonte, W E. Beschorner, D. A. Jabs, R. L. Corio, L. S. Levin, O. M. Colvin, J R. Wingard et al.: Thalidomide for the treatment of chronic graft-versus-host disease. New Engl. J. Med. 326 (1992), 1055-1058.
103. Vogelsang, G. B., A. D. Hess: Graft-versus-host disease: New directions for a persistent problem Blood 84 (1994), 2061-2067.
104. Volc Platzer, B., G Stingl, K. Wolff, W. Hinterberg, W Schnedl: Cytogenetic identification of allogeneic epidermal Langerhans cells in a bone-marrow-graft recipient (letter). New Engl. J. Med. 310 (1984), 1123-1124.
105. Wagner, J. E., N. A Kernan, M. Steinbuch, H. E. Broxmeyer, E. Gluckman: Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease. Lancet 346 (1995), 214-219.
106. Weiden, P. L., N. Flournoy, E. D. Thomas et al : Antileukemic effect of graft-versus-host disease in human recipients of allogeneic marrow grafts. New Engl. J. Med. 300 (1979), 1068-1073.
107. Weiden, P. L., K. M. Sullivan, N. Flournoy, R. Storb, E D Thomas: Antileukemic effect of chronic graft-versus-host disease. New Engl. J. Med. 304 (1981), 1529-1533