Transgenic Expression of a Novel Thymic Epithelial Cell Antigen Stimulates Abberant Development of Thymocytes

Journal of Immunology

Volumn 159, Issue 2, 1997, Pages 726-733

  Takeuchi, Tamotsu ^a,b   Kuro o, Makoto ^a   Miyazawa, Hitoshi ^a   Ohtsuki, Yuji ^b   Yamamoto, Hiroshi ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MEMBRANE ANTIGEN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL DIFFERENTIATION; CYTOLOGY; EPITHELIUM; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; STROMA CELL; T LYMPHOCYTE; THYMUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, SURFACE; CELL DIFFERENTIATION; DNA, COMPLEMENTARY; EPITHELIUM; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; STROMAL CELLS; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0031570938     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. van Ewijk, W. 1991. T-cell differentiation is influenced by thymic microenvironments. Annu. Rev. Immunol. 9:591.
2. Ritter, M. A., and R. L. Boyd. 1993. Development in the thymus; it takes two to tango. Immunol. Today 14:462.
3. Anderson, G., N. C. Moore, J. J. T. Owen, and E. J. Jenkinson. 1996. Cellular interaction in thymocyte development. Annu. Rev. Immunol. 14:73.
4. Shores, E. W., W. van Ewijk, and A. Singer. 1991. Disorganisation and restoration of thymic medullary epithelial-cells in T-cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment. Eur. J. Immunol. 21:1657.
5. Takeuchi, T., T. Tamamoto, H. Tamura, and H. Yamamoto. 1995. Characterization of a 50kDa surface membrane protein on thymic stromal cells as an important factor for early T cell development. Int. Immunol. 7:583.
6. Takeuchi, T., H. Kuzuhara, H. Tamura, C. Hiramine, K. Hojo, and H. Yamamoto. 1993. A 60-kDa thymic epithelial cell surface protein as a potent molecule mediating the cellular interaction with immature T cells. Cell. Immunol. 146:324.
7. Tamura, H., H. Kuzuhara, T. Takeuchi, and H. Yamamoto. 1994. The novel mAb QR6.6 detects a surface molecule on immature thymocytes and inhibits their proliferation on thymic epithelial cells. J. Immunol. 152:1134.
8. Seed, B. 1987. An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2. Nature 329:840.
9. Aruffo, A., and B. Seed. 1987. Molecular cloning of a CD28 cDNA by a high efficiency COS cell expression system. Proc. Natl. Acad. Sci. USA 84:8573.
10. Hirt, B. 1967. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol. 26:365.
11. Henikoff, S. 1984. Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. Gene 28:351.
12. O'Hara, K., C. Benoist, and R. Breathnach. 1981. Transformation of mouse fibroblasts to methotrexate resistance by a recomninant plasmid expressing a prokaryotic dihydrofolate reductase. Proc. Natl. Acad. Sci. USA 78:1527.
13. Mishina, M., T. Kurosaki, T. Tobimatsu, Y. Morimoto, M. Noda, T. Yamamoto, M. Terao, J. Lindstrom, T. Takahashi, M. Kuno, and S. Numa. 1984. Expression of functional acetylcholine receptor from cloned cDNAs. Nature 307:604.
14. Nikaido, T., A. Shimizu, N. Ishida, H. Sabe, K. Teshigawara, M. Maeda, T. Uchiyama, J. Yodoi, and T. Honjo. 1984. Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature 311:631.
15. Nishi, M., Y. Ishida, and T. Honjo. 1988. Expression of functional interleukin-2 receptors in human light chain/Tac transgenic mice. Nature 331:267.
16. Fujita, K., N. Miki, M. P. Mojika, S. Takao, J. Phuchareon, S. Nishikawa, T. Sudo, and T. Tokuhisa. 1993. B cell development is perturbed in bone marrow from c-fos/v-jun doubly transgenic mice. Int. Immunol. 5:227.
17. Waterston, R., C. Martin, M. Craxton, C. Huynh, A. Coulson, L. Hillier, R. Durbin, P. Green, R. Shownkeen, N. Halloran, M. Metzstein, T. Hawkins, R. Wilson, M. Berks, Z. Du, K. Thomas, J. Thierry-Mieg, and J. Sulston. 1992. A survey of expressed genes in Caenorhabditis elegans. Nat. Genet. 1:114.
18. Wright, M. D., and M. D. Tomlinson. 1994. The ins and outs of the transmembrane 4 superfamily. Immunol. Today 15:588.
19. Boismenu, R., M. Rhein, W. H. Fischer, and W. L. Havran. 1996. A role for CD81 in early T cell development. Science 271:198.
20. Ruther, U., W. Muller, T. Sumida, T. Tokuhisa, K. Rajewsky, and E. F. Wagner. 1988. c-fos expression interferes with thymus development in transgenic mice. Cell 53:847.
21. Borgulya, P., H. Kishi, U. Muller, J. Kirberg, and H. von Boehmer. 1991. Development of the CD4 and CD8 lineage of T cells: instruction versus selection. EMBO J. 10:913.
22. Kisielow, P., and A. Miazek. 1995. Positive selection of T-cells: rescue from programmed cell-death and differentiation require continuous engagement of the T cell receptor. J. Exp. Med. 181:1975.
23. + thymocytes in vitro. J. Exp. Med. 179:2027.
24. Lundberg, K., and K. Shortman. 1994. Small cortical thymocytes are subject to positive selection. J. Exp. Med. 179:1475.