Deviated Overexpression of TCR-β, TCR-γ, CD4, and CD8 on Thymic Lymphomas Induced by 1-Propyl-1-Nitrosourea: Destruction of the Allelic Exclusion of TCR-β and Expression of Functional TCR-βγ Heterodimer on a Lymphoma, cFTL53

Journal of Immunology

Volumn 159, Issue 2, 1997, Pages 748-756

  Kinebuchi, Miyuki ^a   Matsuura, Akihiro ^a   Ogiu, Toshiaki ^b   Kikuchi, Kokichi ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; NITROSOUREA DERIVATIVE; PROPYLNITROSOUREA;

ALLELE; AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; DIMERIZATION; FISCHER 344 RAT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LYMPHOMA; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RAT; THYMOMA;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; BASE SEQUENCE; DIMERIZATION; GENE EXPRESSION REGULATION, NEOPLASTIC; LYMPHOMA; MOLECULAR SEQUENCE DATA; NITROSOUREA COMPOUNDS; RATS; RATS, INBRED F344; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; THYMUS NEOPLASMS;

EID: 0031570838     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Mombaterts, P., A. Clark, M. Rudnicki, J. Iacomini, S. Itohara, J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M. Hooper, and S. Tonegawa. 1992. Mutations in T-cell antigen receptor genes a and β block thymocyte development at different stages. Nature 360:225.
2. Philpott, K., J. Viney, G. Kay, S. Rastan, E. Gardiner, S. Chae, A. Hayday, and M. Owen. 1992. Lymphoid development in mice congenitally lacking T cell receptor αβ-expressing cells. Science 256:1448.
3. Itohara, S., P. Mombaerts, J. Lafaille, J. Iacomini, A. Nelson, A. Clarke, M. Hooper, A. Farr, and S. Tonegawa. 1993. T cell receptor δ gene mutant mice: independent generation of αβ T cells and programmed rearrangements of γδ TCR genes. Cell 72:337.
4. Raulet, D., R. Garman, H. Saito, and S. Tonegawa. 1985. Developmental regulation of T-cell receptor gene expression. Nature 314:103.
5. Harvan, W., and J. Allison. 1988. Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors. Nature 335:443.
6. Umematsu, Y., S. Ryser, Z. Dembic, P. Borgulya, P. Krimpenfort, A. Berns, H. Boehmer, and M. Steinmetz. 1988. In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes. Cell 52:831.
7. Krimpenfort, P., F. Ossendorp, F. Borst, C. Melief, and A. Berns. 1989. T cell depletion in transgenic mice carrying a mutant gene for TCR-β. Nature 341:742.
8. Yeung, R., J. Penninger, and W. T. Mak. 1994. T-cell development and function in gene-knockout mice. Curr. Opin. Immunol. 6:298.
9. Snodgrass, H., Z. Dembic, M. Steinmetz, and H. von Boehmer. 1985. Expression of T-cell antigen receptor genes during fetal development in the thymus. Nature 315:232.
10. Snodgrass, H. R., P. Kisielow, M. Kiefer, M. Steinmetz, and H. von Boehmer. 1985. Ontogeny of the T-cell antigen receptor within the thymus. Nature 313: 592.
11. Suzuki, Y., M. Matsuyama, and T. Ogiu. 1984. Morphologic characteristics of thymic lymphoma induced by N-nitroso-N-propylurea in F344 rats. J. Natl. Cancer Inst. 72:367.
12. Uede, T., Y. Ishii, A. Matsuura, and K. Kikuchi. 1982. Thy-1 antigen on rat bone marrow cells: immunochemical and fine morphological studies. Tohoku J. Exp. Med. 136:391.
13. Ishii, Y., A. Matsuura, H. Iwaki, T. Takami, and K. Kikuchi. 1984. Two closely related antigens expressed on granulocytes, macrophages and some reticular elements in rat lymphoid tissues: characterization by monoclonal antibodies. Immunology 51:477.
14. Matsuura, A., Y. Ishii, H. Yuasa, H. Narita, S. Kon, T. Takami, and K. Kikuchi. 1984. Rat T lymphocyte antigens comparable with mouse Lyt-1 and Lyt-2,3 antigenic systems: characterization by monoclonal antibodies. J. Immunol. 132: 316.
15. Matsuura, A., T. Murakami, D. Kozutsumi, M. Kinebuchi, K. Onodera, S. Kon, and K. Kikuchi. 1993. Molecular cloning of cDNA encoding rat homologue of CD5 and CD8α: evidence that R1-3B3 and R1-10B5 monoclonal antibodies detect rat CD5 and CD8 antigens, respectively. Transplant. Proc. 25:2793.
16. Kinebuchi, M., T. Ide, D. Lupin, T. Tamatani, M. Miyasaka, A. Matsuura, Y. Nagai, K. Kikuchi, and T. Uede. 1991. A novel cell surface antigen involved in thymocyte and thymic epithelial cell adhesion. J. Immunol. 146:3721.
17. Torimoto, Y., M. Kinebuchi, A. Matsuura, K. Kikuchi, and T. Uede. 1990. A monoclonal antibody (8H3) that binds to rat T lineage cells and augments in vitro proliferative responses. J. Exp. Med. 172:1315.
18. Matsuura, A., Y. Ishii, H. Iwaki, and K. Kikuchi. 1985. A novel cell-surface antigen expressed on most leukocytes and a minor cortisone-resistant population of thymocytes in rats: characterization by monoclonal antibodies. Microbiol. Immunol. 29:873.
19. Tanaka, T., T. Masuko, H. Yagita, T. Tamura, and Y. Hashimoto. 1989. Characterization of a CD3-like rat T cell surface antigen recognized by a monoclonal antibody. J. Immunol. 142:2791.
20. Hünig, T., J. Wallny, K. Hartley, A. Lawetzky, and G. Tiefenthhaler. 1989. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation: differential reactivity with subsets of immature and mature T lymphocytes. J. Exp. Med. 169:73.
21. Kinebuchi, M., K. Kikuchi, and A. Matsuura. 1995. The determinant of R73 MAb exists on the constant domain of rat T-cell receptor β-chain. Transplant. Proc. 27:1511.
22. Iwamoto, I., P. Ohashi, H. Pircher, L. C. Walker., E. E. Michalopoulos, F. Rupp, H. Hengartner, and W. T. Mak. 1987. T cell receptor variable gene usage in a specific cytotoxic T cell response. J. Exp. Med. 165:591.
23. Kishihara, K., Y. Yoshikai, G. Matsuzaki, S. Tomooka, and K. Nomoto. 1988. Radioresistant intrathymic T cell precursors express T cell receptor Cγ4- and Cδ-specific gene messages. Eur. J. Immunol. 18:841.
24. Kinebuchi, M., K. Kikuchi, and A. Matsuura. 1994. Rat T-cell receptor gamma chain sequences: identification of conserved gene segments and a unique chimeric constant region gene. C4L. Immunogenetics 40:449.
25. Carrey, E. A. 1989. Peptide mapping. In Protein Structure. T. E. Creighton, ed. IRL Press, Oxford, U.K., p. 119.
26. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440.
27. Davis, S., and P. A. van der Merwe. 1996. The structure and ligand interactions of CD2: implications for T-cell function. Immunol. Today 17:177.
28. Tarakhovsky, A., S. B. Kanner, J. Hombach, J. A. Ledbetter, W. Muller, N. Killeen, and K. Rajewsky. 1995. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269:535.
29. Manjunath, N., M. Correa, M. Ardman, and B. Ardman. 1995. Negative regulation of T-cell adhesion and activation by CD43. Nature 377:535.
30. Ogiu, T., K. Utsumi, H. Fukami, and M. Matsuyama. 1988. Cytogenetic studies of rat thymic lymphomas induced by N-propyl-N-nitrosourea. Leukemia Res. 12:607.
31. Shisa, H., and H. Hiai. 1985. Genetically determined susceptibility of Fisher 344 rats to propylnitrosourea-induced thymic lymphomas. Cancer Res. 45:1483.
32. Ogiu, T., and H. Fukami. 1987. Existence of N-nitroso-N-propylurea target cells in the thymus of F344 rats in thymic lymphomagenesis. J. Natl. Cancer Inst. 79:179.
33. Groettrup, M., K. Ungewiss, O. Azogui, R. Palacios, M. Owen, A. Hayday, and H. von Boehmer. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein. Cell 75:283.
34. Saint-Ruf, C., K. Ungewiss, M. Groettrup, L. Bruno, H. J. Fehling, and H. von Boehmer. 1994. Analysis and expression of cloned pre-T cell receptor gene. Science 266:1208.
35. Bonneville, M., I. Ishida, P. Mombaerts, M. Katsuki, S. Verbeek, A. Berns, and S. Tonegawa. 1989. Blockage of αβ T-cell development by TCR-γδ transgenes. Nature 342:931.
36. Ishida, I., S. Verbeek, M. Bonneville, S. Itohara, A. Berns, and S. Tonegawa. 1990. T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells. Proc. Natl. Acad. Sci. USA 87:3067.