Inhibitory Activity of IL-1 Receptor Antagonist Depends on the Balance between Binding Capacity for IL-1 Receptor Type 1 and IL-1 Receptor Type II

Journal of Immunology

Volumn 158, Issue 8, 1997, Pages 3881-3887

  Ruggiero, Paolo ^a   Bossù, Paola ^a   Macchia, Giovanni ^a   Del Grosso, Egidio ^b   Sabbatini, Vilma ^a   Bertini, Riccardo ^a   Colagrande, Antonella ^b   Bizzarri, Cinzia ^b   Maurizi, Giovanni ^b   Di Cioccio, Vito ^c   D'Andrea, Gabriele ^d   Di Giulio, Antonio ^d   Frigerio, Francesco ^e   Grifantini, Renata ^e,f   Grandi, Guido ^e,f   Tagliabue, Aldo ^a   Boraschi, Diana ^a  

^a Chemistry Section   (Italy)

^b Biolaq Consortium   (Italy)

^c NIRECO Consortium   (Italy)

^d UNIVERSITY OF L'AQUILA   (Italy)

^e Eniricerche SpA   (Italy)

^f CHIRON VACCINES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IL1RN PROTEIN, HUMAN; IL1RN PROTEIN, MOUSE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RECOMBINANT PROTEIN; SIALOGLYCOPROTEIN;

ANIMAL; ARTICLE; C3H MOUSE; CELL LINE; DRUG ANTAGONISM; FEMALE; GENETICS; HUMAN; METABOLISM; MOUSE; MUTATION; PROTEIN BINDING;

ANIMALS; CELL LINE; FEMALE; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; MICE; MICE, INBRED C3H; MUTATION; PROTEIN BINDING; RECEPTORS, INTERLEUKIN-1; RECOMBINANT PROTEINS; SIALOGLYCOPROTEINS;

EID: 0031569584     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Dinarello, C. A. 1991. Interleukin-1 and interleukin-1 antagonism. Blood 77:1627.
2. Arend, W. P. 1991. Interleukin 1 receptor antagonist. A new member of the interleukin 1 family. J. Clin. Invest. 88:1445.
3. Dinarello, C. A. 1996. Biological basis for interleukin-1 in disease. Blood 87:2095.
4. Ohlsson, K., P. Björk, M. Bergenfeldt, R. Hageman, and R. C. Thompson. 1990. Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature 348:550.
5. Wakabayashi, G., J. A. Gelfand, J. F. Burke, R. C. Thompson, and C. A. Dinarello. 1991. A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits. FASEB J. 5:338.
6. Alexander, H. R., G. M. Doherty, C. M. Buresh, D. J. Venzon, and J. A. Norton. 1991. A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice. J. Exp. Med. 173:1029.
7. Fisher, C. J., J.-F. Dhainaut, S. M. Opal, J. P. Pribble, R. A. Balk, G. J. Slotman, T. J. Iberti, E. C. Rackow, M. J. Shapiro, R. L. Greenman, H. D. Reines, M. P. Shelly, B. W. Thompson, J. F. LaBrecque, M. A. Catalano, W. A. Knaus, and J. C. Sadoff. 1994. Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. JAMA 271:1836.
8. Sims, J. E., C. J. March, D. Cosman, M. B. Widmer, H. R. MacDonald, C. J. McMahan, C. E. Grubin, J. M. Wignall, J. L. Jackson, S. M. Call, D. Friend, A. R. Alpert, S. Gillis, D. L. Urdal, and S. K. Dower. 1988. cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 241:585.
9. Hannum, C. H., C. J. Wilcox, W. P. Arend, F. G. Joslin, D. J. Dripps, P. L. Heimdal, L. G. Armes, A. Sommer, S. P. Eisenberg, and R. C. Thompson. 1990. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343:336.
10. Slack, J., C. J. McMahan, S. Waugh, K. Schooley, M. K. Spriggs, J. E. Sims, and S. K. Dower. 1993. Independent binding of interleukin-1α and interleukin-1β to type I and type II receptors. J. Biol. Chem. 268:2513.
11. Scapigliati, G., P. Ghiara, M. Bartalini, A. Tagliabue, and D. Boraschi. 1989. Differential binding of IL-1α and IL-1β to receptors on B and T cells. FEBS Lett. 243:394.
12. Greenfeder, S. A., P. Nunes, L. Kwee, M. Labow, R. A. Chizzonite, and G. Ju. 1995. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J. Biol. Chem. 270:13757.
13. McMahan, C. J., J. L. Slack, B. Mosley, D. Cosman, S. D. Lupton, L. L. Brunton, C. E. Grubin, J. M. Wignall, N. A. Jenkins, C. I. Brannan, N. G. Copeland, K. Hübner, C. M. Croce, L. A. Cannizzaro, D. Benjamin, S. K. Dower, M. K. Spriggs, and J. E. Sims. 1991. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 10:2821.
14. Symons, J. A., J. A. Eastgate, and G. W. Duff. 1990. A soluble binding protein specific for IL-1β is produced by activated mononuclear cells. Cytokine 2:190.
15. Giri, J. G., R. C. Newton, and R. Horuk. 1990. Identification of soluble interleukin-1 binding protein in cell-free supernatants: evidence for soluble interleukin-1 receptor. J. Biol. Chem. 265:17416.
16. Colotta, F., F. Re, M. Muzio, R. Bertini, N. Polentarutti, M. Sironi, J. G. Giri, S. K. Dower, J. E. Sims, and A. Mantovani. 1993. Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 261:472.
17. Bossù, P., U. Visconti, P. Ruggiero, G. Macchia, M. Muda, R. Bertini, C. Bizzarri, A. Colagrande, V. Sabbatini, G. Maurizi, E. Del Grosso, A. Tagliabue, and D. Boraschi. 1995. Transfected type II interleukin-1 receptor impairs responsiveness of human keratinocytes to interleukin-1. Am. J. Pathol. 147:1852.
18. Symons, J. A., P. R. Young, and G. W. Duff. 1995. Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1β precursor and loses affinity for IL-1 receptor antagonist. Proc. Natl. Acad. Sci. USA 92:1714.
19. Granowitz, E. V., B. D. Clark, J. Mancilla, and C. A. Dinarello. 1991. Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor. J. Biol. Chem. 266:14147.
20. Dripps, D. J., E. Verderber, R. K. Ng, R. C. Thompson, and S. P. Eisenberg. 1991. Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils. J. Biol. Chem. 266:20311.
21. Arend, W. P., M. Malyak, M. F. Smith, Jr., T. D. Whisenand, J. L. Slack, J. E. Sims, J. G. Giri, and S. K. Dower. 1994. Binding of IL-1α, IL-1β, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. J. Immunol. 153:4766.
22. Burger, D., R. Chicheportiche, J. G. Giri, and J.-M. Dayer. 1995. The inhibitory activity of interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble receptor. J. Clin. Invest. 96:38.
23. Ju, G., E. Labriola-Tompkins, C. A. Campen, W. R. Benjamin, J. Karas, J. Plocinski, D. Biondi, K. L. Kaffka, P. L. Kilian, S. P. Eisenberg, and R. J. Evans. 1991. Conversion of the interleukin 1 receptor antagonist into an agonist by site-specific mutagenesis. Proc. Natl. Acad. Sci. USA 88:2658.
24. Labriola-Tompkins, E., C. Chandran, K. L. Kaffka, D. Biondi, B. J. Graves, M. Hatada, V. S. Madison, J. Karas, P. L. Kilian, and G. Ju. 1991. Identification of the discontinuous binding site in human interleukin 1β for the type I interleukin 1 receptor. Proc. Natl. Acad. Sci. USA 88:11182.
25. Veerapandian, B., G. L. Gilliland, R. Raag, A. L. Svensson, Y. Masui, Y. Hirai, and T. L. Poulos. 1992. Functional implications of interfeukin-1β based on the three-dimensional structure. Proteins Struct. Funct. Genet. 12:10.
26. Simon, P. L., V. Kumar, J. S. Lillquist, P. Bhatnagar, R. Einstein, J. Lee, T. Porter, D. Green, G. Sathe, and P. R. Young. 1993. Mapping of neutralizing epitopes and the receptor binding site of human interleukin 1β. J. Biol. Chem. 268:9771.
27. Grütter, M. G., J. van Oestrum, J. P. Priestle, E. Edelmann, U. Joss, U. Feige, K. Vosbeck, and A. Schmitz. 1994. A mutational analysis of receptor binding sites of interleukin-1β: differences in binding of human interleukin-1β muteins to human and mouse receptors. Protein Eng. 7:663.
28. Evans, R. J., J. Bray, J. D. Childs, G. P. A. Vigers, B. J. Brandhuber, J. J. Skalicky, R. C. Thompson, and S. E. Eisenberg. 1995. Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1β by site-directed mutagenesis: identification of a single site in IL-1ra and two sites in IL-1β. J. Biol. Chem. 270:11477.
29. Boraschi, D., P. Bossù, P. Ruggiero, A. Tagliabue, R. Bertini, G. Macchia, C. Gasbarro, L. Pellegrini, G. Melillo, E. Ulisse, U. Visconti, C. Bizzarri, E. Del Grosso, A. R. Mackay, G. Frascotti, F. Frigerio, R. Grifantini, and G. Grandi. 1995. Mapping of receptor binding sites on IL-1β by reconstruction of IL-1ra-like domains. J. Immunol. 155:4719.
30. Velati Bellini, A., G. Galli, E. Fascetti, G. Frascotti, P. Branduzzi, G. Lucchese, and G. Grandi. 1991. Production processes of recombinant IL-1β from Bacillus subtilis: comparison between intracellular and exocellular expression. J. Biotechnol. 18:177.
31. Maurizi, G., P. Bossù, D. Boraschi, E. Ulisse, A. Tagliabue, D. Boraschi, and P. Ruggiero. 1995. Sporulation: an alternative way to recover recombinant proteins from Bacillus subtilis. Biotechnol. Bioeng. 48:197.
32. Boukamp, P., R. T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham, and N. E. Fusenig. 1988. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106:761.
33. Stoppacciaro, A., P. Bossù, P. Ghiara, L. P. Ruco, S. Censini, G. Scapigliati, S. Nuti, A. Tagliabue, C. D. Baroni, and D. Boraschi. 1991. Binding of IL-1β to IL-1R type II at single cell level. J. Immunol. 147:1561.
34. Munson, P. J., and D. Rodbard. 1980. LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107:220.
35. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:3099.
36. Eftink, M. R. 1991. Fluorescence quenching reactions: probing biological macromolecular structures. In Biophysical and Biochemical Aspects of Fluorescence Spectroscopy. T. G. Dewey, ed. Plenum Press, New York, p. 1.
37. Vigers, G. P. A., P. Caffes, R. J. Evans, R. C. Thompson, S. P. Eisenberg, and B. J. Brandhuber. 1994. X-ray structure of interleukin-1 receptor antagonist at 2.0-Å resolution. J. Biol. Chem. 269:12874.
38. Folliard, F., N. Touchet, and B. Terlain. 1990. Comparison of the binding of IL-1 and mutants on lymphocytes and chondrocytes and their effects on some biological activities: discovery of an IL-1β mutant with dissociated properties. J. Leukocyte Biol. S1:51.
39. Palla, E., G. Bensi, E. Solito, D. Tornese Buonamassa, G. Fassina, G. Raugei, F. Spano, C. Galeotti, M. Mora, M. Domenighini, M. Rossini, E. Gallo, V. Carinci, M. Bugnoli, F. Bertini, L. Parente, and M. Melli. 1993. Loop substitution as a tool to identify active sites of interleukin-1β. J. Biol. Chem. 268:13486.
40. Schreuder, H. A., J. M. Rondeau, C. Tardif, A. Soffientini, E. Sarubbi, A. Akeson, T. L. Bowlin, S. Yanofsky, and R. W. Barrett. 1995. Refined crystal structure of the interleukin-1 receptor antagonist: presence of a disulfide link and a cis-proline. Eur. J. Biochem. 227:838.
41. Kamogashira, T., M. Sakaguchi, Y. Ohmoto, K. Mizuno, R. Shimizu, K. Nagamura, S. Nakai, and Y. Hirai. 1988. Site specific mutagenesis of the human interleukin-1β gene: the role of arginine residue at the N-terminal region. J. Biochem. 104:837.
42. Chang, J.-Y., P. K. Nagai, J. P. Priestle, U. Joss, K. D. Vosbeck, and J. van Oostrum. 1992. Identification of a reactive lysyl residue (Lys103) of recombinant human interleukin 1β: mechanism of its reactivity and implication of its functional role in receptor binding. Biochemistry 31:2874.
43. Stockman, B. J., T. A. Scahill, N. A. Strakalaitis, D. P. Brunner, A. W. Yem, and M. R. Deibel, Jr. 1994. Solution structure of human interleukin-1 receptor antagonist protein. FEBS Lett. 349:79.
44. Finzel, B. C., L. L. Clancy, D. R. Holland, S. W. Muchmore, K. D. Watenpaugh, and H. M. Einspahr. 1989. Crystal structure of recombinant human interleukin-1β at 2.0 Å resolution. J. Mol. Biol. 209:779.
45. Auron, P. E., G. J. Quigley, L. J. Rosenwasser, and L. Gehrke. 1992. Multiple amino acid substitutions suggest a structural basis for the separation of biological activity and receptor binding in a mutant interleukin-1β protein. Biochemistry 31:6632.
46. Eisenberg, S. P., M. T. Brewer, E. Verderber, P. Heimdal, B. J. Brandhuber, and R. C. Thompson. 1991. Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Proc. Natl. Acad. Sci. USA 88:5232.
47. Stockman, B. J., T. A. Scahill, M. Roy, E. L. Ulrich, N. A. Strakalaitis, D. P. Brunner, A. W. Yem, and M. R. Deibel, Jr. 1992. Secondary structure and topology of interleukin-1 receptor antagonist determined by heteronuclear three-dimensional NMR spectroscopy. Biochemistry 31:5237.