Constitutive Tyrosine Phosphorylation of the vav Proto-Oncogene Product in MRL/Mp-lpr/lpr Mice

Journal of Immunology

Volumn 158, Issue 6, 1997, Pages 2977-2983

  Mimura, Toshihide ^a   Minota, Seiji ^c   Nojima, Yoshihisa ^b   Morino, Noritsugu ^a   Hamasaki, Ken ^a   Furuya, Hiroko ^a   Yazaki, Yoshio ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; ONCOPROTEIN; PHOSPHOTYROSINE; TYROSINE; VAV PROTEIN; VAV1 PROTEIN, MOUSE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CYTOLOGY; FEMALE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; PHOSPHORYLATION; SPECIES DIFFERENCE; SPLEEN; T LYMPHOCYTE;

ANIMALS; CELL CYCLE PROTEINS; FEMALE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED MRL LPR; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-VAV; SPECIES SPECIFICITY; SPLEEN; T-LYMPHOCYTES; TYROSINE;

EID: 0031569224     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Cohen, P. L., and R. A. Eisenberg. 1992. The lpr and gld genes in systemic autoimmunity: life and death in Fas lane. Immunol. Today 13:427.
2. Watanabe, F. R., C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
3. Adachi, M., F. R. Watanabe, and S. Nagata. 1993. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc. Natl. Acad. Sci. USA 90:1756.
4. Sobel, E. S., V. N. Kakkanaiah, R. G. Rapoport, R. A. Eisenberg, and P. L. Cohen. 1995. The abnormal lpr double-negative T cell fails to proliferate in vivo. Clin. Immunol. Immunopathol. 74:177.
5. Samelson, L., W. F. Davidson, H. Morse, and R. D. Klausner. 1986. Abnormal tyrosine phosphorylation on T-cell receptor in lymphoproliferative disorders. Nature 324:674.
6. Schlz, W., N. Isakov, M. I. Mally, A. N. Theofilopoulos, and A. Altman. 1988. lpr T cell hyporesponsiveness to mitogen linked to deficient receptor-stimulated phosphoinositide hydrolysis. J. Immunol. 263:3626.
7. - T lymphocytes from lpr/lpr mice. Mol. Cell. Biol. 9:4914.
8. Katzav, S., Z. D. Martin, and M. Barbacid. 1989. vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 8:2283.
9. Galland, F., S. Katzav, and D. Birnbaum. 1992. The products of the mcf-2 and vav proto-oncogenes and of the yeast gene cdc-24 share sequence similarities. Oncogene 7:585.
10. Adams, J. M., H. Houston, J. Allen, T. Lints, and R. Harvey. 1992. The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. Oncogene 7:611.
11. Bustelo, X. R., J. A. Ledbetter, and M. Barbacid. 1992. Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature 356: 68.
12. Margolis, B., P. Hu, S. Katzav, W. Li, J. M. Oliver, A. Ullrich, A. Weiss, and J. Schlessinger. 1992. Tyrosine phosphorylation of rat proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 356:71.
13. Bustelo, X. R., and M. Barbacid. 1992. Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells. Science 256:1196.
14. Evans, G. A., O. M. Howard, R. Erwin and W. L. Farrar. 1993. Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells: lack of requirement for the tyrosine kinase lck. Biochem. J. 294:339.
15. August, A., S. Gibson, Y. Kawakami, T. Kawakami, G. B. Mills, and B. Dupont. 1994. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line. Proc. Natl. Acad. Sci. USA 91:9347.
16. Miura, O., Y. Miura, N. Nakamura, F. W. Quelle, B. A. Witthuhn, J. N. Ihle, and N. Aoki. 1994. Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor. Blood 84:4135.
17. vav, in human hemopoietic cells. J. Biol. Chem. 267:18021.
18. Dosil, M., S. Wang, and I. R. Lemischka. 1993. Mitogenic signaling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells. Mol. Cell. Biol. 13:6572.
19. vav, in platelets. J. Biol. Chem. 271:7544.
20. ras through tyrosine phosphorylation of the protooncogene product Vav. Proc. Natl. Acad. Sci. USA 93:8431.
21. Gulbins, E., K. M. Coggeshall, G. Baier, S. Katzav, P. Burn, and A. Altman. 1993. Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. Science 260:822.
22. Zhang, R., F. W. Alt, L. Davidson, S. H. Orkin, and W. Swat. 1995. Defective signaling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374:470.
23. + thymocytes. Nature 374:474.
24. Ceredig, R., J. W. Lowenthal, M. Nabholz, and H. R. MacDonald. 1985. Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells. Nature 314:98.
25. Sarimiento, M., A. L. Glasebrook, and F. W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt-2 antigen block T cell-mediated cytolysis in the absence of compliment. J. Immunol. 125:2665.
26. Sobel, E. S., P. L. Cohen, and R. A. Eisenberg. 1993. lpr T cells are necessary for autoantibody production in lpr mice. J. Immunol. 150:4160.
27. Mimura, T., P. Fernsten, W. N. Jarjour, and J. B. Winfield. 1990. Autoantibodies specific for different isoforms of CD45 in systemic lupus erythematosus. J. Exp. Med. 172:653.
28. erk-2. J. Biol. Chem. 270:269.
29. + double-negative T cells express CD28 and respond to costimulation with phorbol myristate acetate and antibodies to CD28 and the TCR. J. Immunol. 151:597.
30. Machida, M., H. Mano, and Todokoro, K. 1995. Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. Oncogene 11:619.
31. Huby, R. D., G. W. Carlile, and S. C. Ley. 1995. Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells. J. Biol. Chem. 270:30241.
32. Kon-Kozlowski, M., G. Pani, T. Pawson, and K. A. Siminovitch. 1996. The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells. J. Biol. Chem. 271:3856.
33. Smit, L., G. van der Horst, and J. Borst. 1996. Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors. J. Biol. Chem. 271:8564.
34. Wu, J., D. G. Motto, G. A. Koretzky, and A. Weiss. 1996. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity 4:593.
35. Sakai, R., A. Iwamatsu, N. Hirano, S. Ogawa, T. Tanaka, H. Mano, Y. Yazaki, and H. Hirai. 1994. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 13:3748.