The oral administration of Polysorbate 80 to the immature female rat does not increase uterine weight

Toxicology Letters

Volumn 91, Issue 1, 1997, Pages 19-24

  Williams, J ^a   Odum, J ^a   Lewis, R W ^a   Brady, A M ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Estrogenicity; Polysorbate 80; Uterotrophic assay

Indexed keywords

ESTRADIOL BENZOATE; POLYSORBATE 80;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ESTROGEN ACTIVITY; FEMALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; UTERUS WEIGHT;

ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; INJECTIONS, SUBCUTANEOUS; ORGAN SIZE; POLYSORBATES; RATS; RATS, WISTAR; SURFACE-ACTIVE AGENTS; UTERUS;

ANIMALIA; MAMMALIA;

EID: 0031567098     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(96)03863-5     Document Type: Article

References (11)

1. [1] Gajdova, M., Jakubovsky, J. and Valky, J. (1993) Delayed effects of neonatal exposure to Tween 80 on female reproductive organs in rats. Food Chem. Toxicol. 31, 183-190.
2. [2] Jobling, S., Reynolds, T., White, R., Parker, M.G. and Sumpter, J.P. (1995) A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ. Health Perspect. 103, 582-587.
3. [3] Vilialobos, M., Olea, O., Brotons, J.A., Olea-Serrano, M.F., Ruiz de Almodovar, J.M. and Pedraza, V. (1995) The E-screen assay: Comparison of different MCF7 cell stocks. Environ, Health Perspect. 103, 844-850.
4. [4] Jansen, H.T., Cooke, P.S., Porcelli, J., Liu, T-C. and Hansen, L.G. (1993) Estrogenic and anti estrogenic actions of PCB's in the female rat: in vitro and in vivo studies. Reprod. Toxicol. 7, 237-248.
5. [5] Bulger, W.H. and Kupfer, D. (1985) Estrogenic activity of pesticides and other xenobiotics on the uterus and male reproductive tract. In: J.A. Thomas, K.S. Korach and J.A. McLachlan (Eds.), Endocrine Toxicology, Raven Press, New York, pp. 1-33.
6. [6] Robison, A.K., Mukku, V.R. and Stancel, G.M. (1985) Analysis and characterisation of estrogenic xenobiotics and natural products. In: J.A. McLachlan (Ed.). Estrogens in the Environment II. Influences in Development, Elsevier/North Holland, New York, pp. 107-115.
7. [7] Safe, S.H. (1994) Dietary and environmental estrogens and anti estrogens and their possible role in human disease. Environ. Sci. Pollut. Res. 1, 29-33.
8. [8] Sharpe, R.M. (1994) Could environmental, estrogenic chemicals be responsible for some disorders of human male reproductive development? Curr. Opin. Urol. 4, 295-301.
9. [9] Hammond, B., Katzenellen Bogen, B.S., Krauthammer, N. and McConnell, J. (1979) Estrogenic activity of the insecticide chlordecone (Kepone) and interaction with uterine estrogen receptors. Proc. Natl. Acad. Sci. USA 76, 6641-6645.
10. [10] Heywood, R. and Wadsworth, P.F. (1980) Experimental toxicology of estrogens. Pharmacol. Ther. 8, 125-142.
11. [11] Wakeling, A.E. (1995) Use of pure anti-estrogens to elucidate the mode of action of estrogens. Biochem. Pharmacol. 49, 1545-1549.