Membrane toxicity of opioids measured by protozoan motility

Toxicology

Volumn 117, Issue 1, 1997, Pages 35-44

  Wu, Changhao ^a,b   Fry, Christopher H ^b   Henry, John A ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b INSTITUTE OF UROLOGY AND NEPHROLOGY   (United Kingdom)

Author keywords

Anaesthetic like; Hydrophobicity; Opioids; Partition coefficient; Tetrahymean pyriformis; Toxicity

Indexed keywords

CODEINE; DEXTROPROPOXYPHENE; DIAMORPHINE; MEPTAZINOL; METHADONE; MORPHINE; NALBUPHINE; NALOXONE; NORPROPOXYPHENE; OPIATE; OPIATE ANTAGONIST; PENTAZOCINE; PETHIDINE;

ACUTE TOXICITY; ANESTHESIA; ARTICLE; CARDIOTOXICITY; HYDROPHOBICITY; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROTOZOON; TETRAHYMENA PYRIFORMIS;

ANIMALS; CELL MEMBRANE; CELL MOVEMENT; NALOXONE; NARCOTICS; TETRAHYMENA PYRIFORMIS;

PROTOZOA; TETRAHYMENA PYRIFORMIS;

EID: 0031566994     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(96)03547-0     Document Type: Article

References (73)

1. Acalovschi, I., Ene, V., Lorinezi, E. and Nicolaus, F. (1986) Saddle block with pethidine for perineal operations. Br. J. Anaesth. 58, 1012-1016.
2. Allen, R.D. (1967) Fine structure, construction and possible functions of components of the cortex of Tetrahymena pyriformis. J. Protozool. 14, 553-565.
3. Al-Saadi, D. and Sneader, W.E. (1991) Pharmacological and microbiological evaluations of potential new long-acting local anaesthetics. Arzneim.-Forsch. 41, 1098-1100.
4. Al-Saadi, D., Baillie, A.J., Farrell, W., Sneader, W.E. and Waton, N.G. (1981) Inhibition of protozoan motility by local anaesthetics. J. Pharm. Pharmacol. 33 (Suppl.), 93.
5. Albert, A. (1985) Selective Toxicity: The Physico-chemical Basis of Therapy, 7th edn. Chapman and Hall, London, pp. 612-624.
6. Andrivet, P., Ekherian, J.M., Lienhart, A. and Viars, P. (1987) Motor block induced by spinal injection of pethidine: quantification and comparison with lidocaine. Ann. Fr. Anesth. Reanim. 6, 419-422.
7. Barraclough, C.J. and Lowe, R.A. (1982) Failure of naloxone to reverse the cardiotoxicity of Distalgesic overdose. Postgrad. Med. J. 58, 667-668.
8. Bowman, W.C. and Rand, M.J. (1980) Textbook of Pharmacology. 2nd edn. Blackwell, Oxford, pp. 22.56-22.57.
9. Brodin, P. and Skoglund, L.A. (1990) Dose-response inhibition of rat compound nerve action potential by dextropropoxyphene and codeine compared to morphine and cocaine in vitro. Gen. Pharmacol. 21. 551-553.
10. Cassidy, S.L., Henry, J.A. and Roberts, A.M. (1989) Determination of membrane-stabilizing potency of drugs by video analysis of protozoan motility. Toxicol. Vitro 3. 181-187.
11. Cassidy, S.L., Lympany, P.A. and Henry, J.A. (1988) Lipid solubility of a series of drugs and its relevance to fatal poisoning. J. Pharm. Pharmacol. 40, 130-132.
12. Committee on Safety of Medicines (1985) Current Problems: Death with Dextropropoxyphene (No. 14).
13. Connoly, J.G. and Kerkut, G.A. (1983) Ion regulation and membrane potential in Tetrahymena and Paramecium. Comp. Biochem. Physiol. 76A, 1-16.
14. Dearden, J.C. (1985) Partitioning and lipophilicity in quantitative structure-activity relationships. Environ. Health Perspect. 61, 203-228.
15. De Souza, E.B., Schmidt, W.K. and Kuhar, M.J. (1988) Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic. J. Pharmacol. Exp. Ther. 244, 391-402.
16. Drummer, O.H., Opeskin, K., Syrjanen, M. and Cordner, S. (1992) Methadone toxicity causing death in ten subjects starting on a methadone maintenance program. Am. J. Forensic Med. Pathol. 13, 346-350.
17. Finkle, B.S. (1984) Self-poisoning with dextropropoxyphene and dextropropoxyphene compounds: the USA experience. Hum. Toxicol. 3, 115S-134S.
18. Goldfrank, L., Bresnitz, E. and Weisman, R. (1983) Opioids and opiates. Heart Lung 12, 114-122.
19. Hansch, C. and Dunn, W. (1972) Linear relationships between lipophilic character and biological activity of drugs. J. Pharm. Sci. 61, 1-19.
20. Hassan, H.G., Pilcher, C.W., Akerman, B. and Renck, H. (1989) Antinociceptive effects of localized administration of opioids compared with lidocaine. Reg. Anesth. 14, 138-144.
21. Hayes, W.J., Jr. (1975) Toxicology of Pesticides. Williams and Wilkins, Baltimore.
22. Heaney, R.M. (1983) Left bundle branch block associated with propoxyphene hydrochloride poisoning. Ann. Emerg. Med. 12, 780-782.
23. Hellenbrecht, D., Lemmer, B., Wiethold, G. and Grobecker, H. (1973) Measurement of hydrophobicity, surface activity, local anaesthesia, myocardial velocity as quantitative parameters of the non-specific membrane affinity of nine β-adrenergic blocking agents. Naunyn-Schmiedeberg's Arch. Pharmacol. 227, 221-226.
24. Henry, J.A. and Cassidy, S.L. (1986) Membrane stabilising activity: a major cause of fatal poisoning. Lancet 1, 1414-1417.
25. Hong, C.Y., Yang, W.C. and Chiang, B.N. (1983) Importance of membrane stabilising effect in massive overdose of propranolol: plasma level study in a fatal case. Hum. Toxicol. 2. 511-517.
26. Inturrisi, C.E. (1984) Role of opioid analgesics. Am. J. Med. 77, 27-37.
27. Kaa. E. and Dalgaard, J.B. (1989) Fatal dextropropoxyphene poisonings in Jutland. Denmark. Z. Rechtsmed. 102, 107-115.
28. Kennedy, B.L. and West. T.C. (1967) Effect of morphine on electrically-induced release of autonomic mediators in the rabbit sinoatrial node. J. Pharmacol. Exp. Ther. 157, 149-158.
29. King, L.A. (1985) Ferguson's principle and the prediction of fatal drug levels in blood. Hum. Toxicol. 4, 273-278.
30. Könemann, H. (1981) Fish toxicity test with mixtures of more than two chemicals: a proposal for a quantitative approach and experimental results. Toxicology 19, 229-238.
31. Kosterlitz, H.W., Lees, G.M. and Watt, A.J. (1969) Non-specific effects of morphine-like drugs. Pharmacol. Res. Commun. 1, 42-48.
32. Krantz, T., Thisted, B., Strøm, J., Angelo, H. and Sørensen, M.B. (1985) Severe, acute propoxyphene overdose treated with dopamine. Clin. Toxicol. 23, 347-352.
33. Lader, M. (1983) Abuse of weak opioid analgesics. Hum. Toxicol. 3, 229S-236S.
34. Larpin, R., Vinceut, A. and Perret, C. (1990) Hospital morbidity and mortality of acute opiate intoxication. Presse Med. 19, 1403-1406.
35. Lawson, A.A. and Northridge, D.B. (1987) Dextropropoxyphene overdose, epidemiology, clinical presentation and management. Med. Toxicol. Adverse Drug Exp. 2, 430-444.
36. Leo, A., Hansch, C. and Elkins, D. (1971) Partition coefficients and their uses. Chem. Rev. 71, 525-616.
37. Madsen, P.S., Strøm, J., Reiz, S. and Sørensen, M.B. (1984) Acute self-poisoning in 222 consecutive patients. Acta Anaesthesiol. Scand. 28, 661-665.
38. Marti. A.G., Reig, B.R., Sanz, G.P., Garrido, M.P., Font, R.G. and Corbella, C.J. (1992) Deaths from poisoning in Barcelona (Spain). 1986-1989. Rev. Epidemiol. Sante Publique 40, 102-107.
39. Machemer, H. (1988) Motor control of cilia. In: H.-D. Görtz (Ed), Paramecium. Springer, Berlin, pp. 216-235.
40. Magnan, J., Paterson, S.J., Tavani, A. and Kosterlitz, H.W. (1982) The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties. Naunyn-Schmiedeberg's Arch. Pharmacol. 319, 197-205.
41. Naitoh, Y. and Eckert. R. (1969) Ionic mechanisms controlling behavioural responses of Paramicium to mechanical stimulation. Science 164, 963-965.
42. Neil, A. and Terenius, L. (1981) D-Propoxyphene acts differently from morphine on opioid receptor-effector mechanisms. Eur. J. Pharmacol. 69. 33-39.
43. Nickander, R.C., Emmerson, J.L., Hynes, M.D., Steinberg, M.I. and Sullivan, H.R. (1984) Pharmacological and toxic effects in animals of dextropropoxyphene and its metabolite. norpropoxyphene: a review. Hum. Toxicol. 3, 13S-36S.
44. Nickander, R., Smits, S.E. and Steinberg. M.I. (1977) Propoxyphene and norpropoxyphene: pharmacologic and toxic effects in animals. J. Pharmacol. Exp. Ther. 200, 245-253.
45. Nunn, J.F., Sturrock, J.E., Wills, E.J., Richmond, J.E. and McPherson, C.K. (1974) The effects of inhalational anesthetics on the swimming velocity of Tetrahymena pyriformis. J. Cell Sci. 15, 537-554.
46. 2+. Biophys. J. 54, 407-410.
47. Ott, P., Dalhoff, K., Hansen, P.B., Loft, S. and Poulsen, H.E. (1990) Consumption, overdose and death from analgesics during a period of over-the-counter availability of paracetamol in Denmark. J. Intern. Med. 227, 423-428.
48. Roth, S.H. (1986) Is drug-induced membrane stabilization a selective or a non-specific phenomenon? Drugs Exp. Clin. Res. 12, 719-722.
49. Schultz, T.W. (1989) Non-polar narcosis: a review of the mechanism of action for baseline aquatic toxicity. In: U.N. Cowgill and L.R. Willian (Eds), Aquatic Toxicology and Hazard Assessment, American Society for Testing and Materials, Philadelphia, PA, pp. 104-109.
50. +-conductance. FEBS Lett. 356, 322-326.
51. Schultz, T.W., Wyatt, N.L. and Lin, D.T. (1990) Structure-toxicity relationships for nonpolar narcotics: a comparison of data from the Tetrahymena, photobacterium and pimephales systems. Bull. Environ. Contam. Toxicol. 44, 67-72.
52. Seeman, P. (1972) The membrane actions of anesthetics and tranquilizers. Pharmacol. Rev. 24, 583-655.
53. Segest, E. (1987) Poisoning with dextropropoxyphene in Denmark. Hum. Toxicol. 6, 203-207.
54. Siegel. C., Sunshine, A., Richman, H., Olson, N.Z., Robissa, N., Cordone, R., Estrada, N. and Laska, E. (1989) Mepazinol and morphine in postoperative pain assessed with a new method for onset and duration. J. Clin. Pharmacol. 29, 1017-1025.
55. Sørensen, M.B., Häggmark, S., Nyhman, P., Madsen, P.S., Ström, J. and Reiz, S. (1985) Circulatory shock following intravenous propoxyphene poisoning: An experimental study of cardiac function and metabolism in pentobarbital-anesthetized pigs. Acta Anaesthesiol. Scand. 29, 130-136.
56. Sørensen, M.B., Ström, J., Madsen, P.S., Angelo, H.R. and Reiz, S. (1984) Haemodynamic, electrocardiographic and cardiometabolic changes after overdose of propoxyphene: An experimental study in pentabarbitone-anaesthetized pigs. Hum. Toxicol. 3, 53S-59S.
57. Smyth, H.F.J., Weil, C.S., West, J.S. and Carpenter, C.P. (1969) An exploration of joint toxic action: Twenty seven industrial chemicals intubated in rats in all possible pairs. Toxicol. Appl. Pharmacol. 14. 340-347.
58. Spiegel, K. and Pasternak, G.W. (1984) Meptazinol: a novel Mu-1 selective opioid analgesic. J. Pharmacol. Exp. Ther. 228, 414-419.
59. Stahl, S.M. and Kasser, I.S. (1983) Pentazocine overdose. Ann. Emerg. Med. 12, 28-31.
60. Staiman, A. and Seeman, P. (1974) The impulse-blocking concentrations of anaesthetics, alcohols, anticonvulsants, barbiturates, and narcotics on phrenic and sciatic nerves. Can. J. Physiol. Pharmacol. 52, 535-550.
61. Stead, A.H. and Moffat, A.C. (1983) A collection of therapeutic, toxic and fatal blood concentrations in man. Hum. Toxicol. 3, 437-464.
62. Steentoft. A., Kaa, E. and Worm, K. (1989) Fatal intoxications in the age groups of 15-34 years in Denmark in 1984 and 1985. A forensic study with special reference to drug addicts. Z. Rechtsmed. 103, 93-100.
63. Strøm, J. (1989) Acute propoxyphene self-poisoning - with special reference to propoxyphene cardiotoxicity and treatment. Dan. Med. Bull. 36, 316-336.
64. Tanabe, H., Kurihara, K. and Kobatake, Y. (1980) Changes in membrane potential and membrane fluidity in Tetrahymena pyriformis in association with chemoreception of hydrophobic stimuli: fluorescence studies. Biochemistry 19, 5339-5344.
65. Veith, G.D., Call, D.J. and Brooke, L.T. (1983) Structure-toxicity relationships for the fathead minnow, Pimephales promelas: narcotic industrial chemicals. Can. J. Fish Aquat. Sci. 40, 743-748.
66. Woods, P.B. and Robinson, M.L. (1981) An investigation of the comparative liposolubilities of β-adrenoceptor blocking agents. J. Pharm. Pharmacol. 33, 172-173.
67. Wu, C. and Henry, J.A. (1990) Deaths of heroin addicts starting on methadone maintenance. Lancet 1, 424.
68. Wu, C. and Henry, J.A. (1994) Interaction between ethanol and opioids in a protozoan assay. Hum. Exp. Toxicol. 13, 145-148.
69. Wu, C., Fry, C.H. and Henry, J.A. (1992a) Cardiotoxicity of methadone: effects on the electromechanical properties of guinea-pig ventricular myocardium. Toxicol. Lett. S201-S202.
70. Wu, C., Fry, C.H. and Henry, J.A. (1992b) Cardiotoxicity of pentazocine: effect on electromechanical properties of guinea-pig myocardium. Hum. Exp. Toxicol. 11, 573-574.
71. 2+ transient - an insight into their negative inotropic effects. Hum. Exp. Toxicol. 12, 432.
72. Young, R.J. (1983) Dextropropoxyphene overdosage: pharmacological considerations and clinical management. Drugs 26, 70-79.
73. Zaman, S., Lamb, J.M., Esberger, D.A. and Pearson, R.M. (1984) Inhibition of sperm motility by opiate drugs. Br. J. Clin. Pharmacol. 18. 302.