Enhanced immunogenicity of B cell lymphoma genetically engineered to express both B7-1 and interleukin-12

Human Gene Therapy

Volumn 8, Issue 18, 1997, Pages 2217-2228

  Pizzoferrato, Eva ^a   Chu, N Randall ^d   Hawley, Teresa S ^a   Lieu, Francis H L ^a   Barber, Brian H ^a   Hawley, Robert G ^a,b   Watts, Tania H ^a   Berinstein, Neil L ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

^d StressGen Biotechnologies Corp   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B CELL LYMPHOMA; CARCINOGENICITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENETIC ENGINEERING; GENETIC TRANSFECTION; IMMUNOGENICITY; MOUSE; NONHUMAN; SURVIVAL;

ANIMALIA; MURINAE;

EID: 0031564332     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.18-2217     Document Type: Article

References (6)

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2. BRUNDA, M.J., LUISTRO, L., WARRIER, R.R., WRIGHT, R.B., HUBBARD, B.R., MURPHY, M., WOLF, S.F., and GATELY, M.K. (1993). Antitumor and antimetastatic activity of interleukin 12 against murine tumor. J. Exp. Med. 178, 1223-1230.
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4. CHAMBERS, B.J., SALCEDO, M., and LJUNGGREN, H.G. (1996). Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1). Immunity 5, 311-317.
5. CHAN, S.H., PERUSSIA, B., GUPTA, J.W., KOBAYASHI, M., POSPISIL, M., YOUNG, H.A., WOLF, S.F., YOUNG, D., CLARK, S.C., and TRINCHIERI, G. (1991). Induction of interferon-g production by natural killer cells stimulatory factoncharacterization of the responder cells and synergy with other inducers. J. Exp. Med. 173, 869-879.
6. CHEN, L., ASHE, S., BRADY, W.A., HELLSTROM, I., HELLSTROM, K.E., LEDBETTER, J.A., MCGOWAN, P., and LINSLEY, G.A., (1992). Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 71, 1093-1102.