Cobalt catalyzed multiple component condensation route to β-acetamido carbonyl compound libraries

Tetrahedron Letters

Volumn 38, Issue 6, 1997, Pages 1083-1086

  Mukhopadhyay, Manoj ^a   Bhatia, Beena ^a   Iqbal, Javed ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE DERIVATIVE;

ARTICLE; CATALYSIS; DIASTEREOISOMER; DRUG SYNTHESIS; IN VITRO STUDY; METHODOLOGY; REACTION ANALYSIS;

EID: 0031562069     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(96)02474-4     Document Type: Article

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19. 7. In a typical experimental procedure, 1,3-dicarbonyl compound / ketone (5 mmol) and aldehyde (5.5 mmol) were taken in acetonitrile (30 mL) and the mixture was heated under nitrogen balloon at 80°C in the presence of catalytic amount of cobalt(II) chloride (10 mg) and acetyl chloride (10 mmol). The progress of the reaction was monitered by TLC. Removal of acetonitrile followed by bicarbonate workup afforded a residue which on column chromatography yielded the product β-acetamido ketone.