Determination of ebrotidine and its metabolites in human urine by reversed-phase ion-pair high-performance liquid chromatography

Journal of Chromatography B: Biomedical Applications

Volumn 688, Issue 1, 1997, Pages 107-115

  Rozman, Elena ^a   Galcerán, M Teresa ^b   Albet, Carlos ^a  

^a Centro de Investigaciones Farmaceuticos Grupo Ferrer   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

4 Bromobenzenesulfonamide; Desthiazolylebrotidine sulfone; Desthiazolylebrotidine sulfoxide; Ebrotidine; Ebrotidine sulfone; Ebrotidine sulfoxide

Indexed keywords

ACETYLSALICYLIC ACID; AMOXICILLIN; CAFFEINE; CIMETIDINE; CODEINE; DIAZEPAM; DRUG METABOLITE; EBROTIDINE; HISTAMINE H2 RECEPTOR ANTAGONIST; IMIPRAMINE; OMEPRAZOLE; PARACETAMOL; RANITIDINE; THEOPHYLLINE;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; HUMAN; HUMAN EXPERIMENT; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; URINALYSIS;

EID: 0031561775     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0378-4347(97)88062-0     Document Type: Article

References (24)

1. Anglada L., Márquez M., Sacristán A., Ortiz J.A. Eur. J. Med. Chem. 23:1988;97.
2. Konturek S.J., Brzozowski T., Drozdowicz S., Majka J. Eur. J. Gastroenterol. Hepatol. 3:1991;941.
3. Slomiany B.L., Piotrowski J., Murty V.L.N., Slomiany A. Gen. Pharmacol. 23:1992;719.
4. Piotrowski J., Yamaki K., Morita M., Slomiany A., Slomiany B.L. Biochem. Int. 26:1992;659.
5. Konturek S.J., Maczka K., Kaminski K., Sito E., Torres J., Oleksy J. Scand. J. Gastroenterol. 27:1992;438.
6. Konturek S.J., Kwiecien N., Sito E., Obtulowicz W., Kaminski K., Oleksy J. Scand. J. Gastroenterol. 28:1993;1047.
7. Slomiany B.L., Piotrowski K., Mojtahed H., Slomiany A. Gen. Pharmacol. 23:1992;203.
8. Piotrowski J., Morita M., Slomiany A., Slomiany B.L. Biochem. Int. 27:1992;131.
9. Lin J.H. Clin. Pharmacokinet. 20:(3):1991;218.
10. Albet C., Perez J.A., Marquez M., Rozman E., Herrero E., Sacristan A., Ortiz J.A. Methods Find. Exp. Clin. Pharmacol. 16:(1):1994;124.
11. Carey P.F., Martin L.E., Owen P. J. Chromatogr. 225:1981;161.
12. Mitchell S.C., Idle J.R., Smith R.L. Xenobiotica. 12:1982;283.
13. Kawai R., Imasaki H., Kawamura S. Oyo Yakuri. 26:1983;927.
14. Chem. Abstr. 100:1984;203040.
15. Lee R.M., McDowall R.D. J. Chromatogr. 273:1983;335.
16. Rozman E., Galcerán M.T., Anglada L., Albet C. J. Pharm. Sci. 83:1994;252.
17. Rozman E., Galcerán M.T., Anglada L., Albet C. Drug. Metab. Dispos. 23:1995;976.
18. Prueksaritanont T., Sittichai N., Prueksaritanont S., Vongsaroj R. J. Chromatogr. 490:1989;175.
19. Strong H.A., Spino M. J. Chromatogr. 422:1987;301.
20. Ziemniak J.A., Chiarmonte D.A., Schentag J.J. Clin. Chem. 27:(2):1981;272.
21. Rozman E., Galcerán M.T., Albet C. Rapid Commun. Mass Spectrom. 9:1995;1492.
22. Snyder L.R., Kirkland J.J. 2nd ed. Introduction to Modern Liquid Chromatography. 1979;459 John Wiley and Sons, New York.
23. Snyder L.R., Kirkland J.J. 2nd ed. Introduction to Modern Liquid Chromatography. 1979;462 John Wiley and Sons, New York.
24. Fleitman J., Torosian G., Perrin J.H. J. Chromatogr. 229:1982;255.