A model for quantifying the contribution of extracellularly-derived peptides to milk protein synthesis in the ruminant mammary gland

Journal of Theoretical Biology

Volumn 185, Issue 3, 1997, Pages 379-388

  France, J ^a   Hanigan, M D ^b   Bequette, B J ^c   Metcalf, J A ^d   Beever, D E ^d   Lobley, G E ^c   MacRae, J C ^c   Backwell, F R C ^c  

^a ABERYSTWYTH UNIVERSITY   (United Kingdom)

^b Purina Mills LLC   (United States)

^c ROWETT RESEARCH INSTITUTE   (United Kingdom)

^d UNIVERSITY OF READING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; MILK PROTEIN; PEPTIDE; TRACER;

ARTERIAL BLOOD; ARTICLE; BLOOD FLOWMETRY; BOVIDS; MAMMARY GLAND; MATHEMATICAL MODEL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS;

EID: 0031557648     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.1996.0317     Document Type: Article

References (26)

1. ADIBI, S. A. & JOHNS, B. A. (1984). Partial substitution of amino acids of a parenteral solution with tripeptides: effects on parameters of protein nutrition in baboons. Metabolism 33, 420-424.
2. BACKWELL, F. R. C. (1994). Peptide utilisation by tissues: current status and applications of stable isotope procedures. Proc. Nutr. Soc. 53, 457-464.
3. BACKWELL, F. R. C., BEQUETTE, B. J., WILSON, D., CALDER, A. G., METCALF, J. A., WRAY-CAHEN, D. et al. (1994). The utilisation of dipeptides by the caprine mammary gland for milk protein synthesis. Am. J. Physiol. 267, R1-R6.
4. BEQUETTE, B. J., BACKWELL, F. R. C., DHANOA, M. S., WALKER, A., CALDER, A. G., WRAY-CAHEN, D. et al. (1994). Kinetics of blood free and milk casein-amino acid labelling in the dairy goat at two stages of lactation. Br. J. Nutr. 72, 211-220.
5. BEQUETTE, B. J., BACKWELL, F. R. C., MACRAE, J. C., LOBLEY, G. E., CROMPTON, L. A., METCALF, J. A., et al. (1996a). Effect of intravenous amino acid infusion on leucine oxidation across the mammary gland of the lactating goat. J. Dairy Sci. 79, 2217-2224.
6. BEQUETTE, B. J., METCALF, J. A., WRAY-CAHEN, D., BACKWELL, F. R. C., SUTTON, J. D., LOMAX, M. A. et al. (1996b). Leucine and protein metabolism in the lactating dairy cow mammary gland: responses to supplemental dietary crude protein intake. J. Dairy Res. 63, 209-222.
7. FRANCE, J., BEQUETTE, B. J., LOBLEY, G. E., METCALF, J. A., WRAY-CAHEN, D., DHANOA, M. S. et al. (1995). An isotope dilution model for partitioning leucine uptake by the mammary gland. J. theor. Biol. 172, 369-377.
8. HANIGAN, M. D. & BALDWIN, R. L. (1994). A mechanistic model of mammary gland metabolism in the lactating cow. Agricultural Systems 45, 369-419.
9. HARRIS, P. M., SKENE, P. A., BUCHAN, V., MILNE, E., CALDER, A. G., ANDERSON, S. E. et al. (1992). Effect of food intake on hind-limb and whole-body protein metabolism in young growing sheep: chronic studies based on artetio-venous techniques. Br. J. Nutr. 68, 389-407.
10. KRZYSIK, B. A. & ADIBI, S. A. (1977). Cytoplasmic dipeptidase activities of kidney, ileum, jejunum, liver, muscle and blood. Am. J. Physiol. 233, E450-456.
11. LOCHS, H., MORSE, E. L. & ADIBI, S. A. (1986). Mechanism of hepatic assimilation of dipeptides - transport versus hydrolysis. J. Biol. Chem. 261, 4976-4981.
12. LOCHS, H., WILLIAMS, P. E., MORSE, E. L., ABUMRAD, N. N. & ADIBI, S. A. (1988). Metabolism of dipeptides and their constituent amino acids by liver, gut, kidney, and muscle. Am. J. Physiol. 254, E588-E594.
13. MCCORMICK, M. E. & WEBB, K. E., JR. (1982). Plasma free, erythrocyte free and plasma peptide amino acid exchange of calves in steady state and fasting metabolism. J. Nutr. 112, 276-282.
14. METCALF, J. A., BEEVER, D. E., SUTTON, J. D., WRAY-CAHEN, D., EVANS, R. T., HUMPHRIES, D. J. et al. (1994). The effect of supplementary protein on in vivo metabolism of the mammary gland in lactating dairy cows. J. Dairy Sci. 77, 1816-1827.
15. ODDY, V. H. & LINDSAY, D. B. (1986). Determination of the rates of protein synthesis, gain and degradation in intact hind-limb muscle of lambs. Biochem. J. 233, 417-425.
16. ODDY, V. H., LINDSAY, D. B. & FLEET, I. R. (1988). Protein synthesis and degradation in the mammary gland of goats. J. Dairy Res. 55, 143-154.
17. PIEZ, K. A., OYAMA, V. I., LEVOMTOW, L. & EAGLE, H. (1960). Proteolysis in stored serum and its possible significance in cell culture. Nature 188, 59-60.
18. RAZOOKI HASAN, H., WHITE, D. A. & MAYER, R. J. (1982). Extensive destruction of newly synthesized casein in mammary explants in organ culture. Biochem. J. 202, 133-138.
19. ROTH, E., KARNER, J., OLLENSCHLAGER, G., KARNER, J., SIMMEL, A., FURST, P. & FUNOVICS, J. (1988). Alanylglutamine reduces muscle loss of alanine and glutamine in postoperative anethetized dogs. Clin. Sci. 75, 641-648.
20. SEAL, C. J. & PARKER, D. S. (1991). Isolation and characterization of circulating low molecular weight peptides in steer, sheep and rat portal and peripheral blood. Comp. Biochem. Physiol. 99B, 679-685.
21. STEHLE P., ALBERS, S. & FURST, P. (1988). Stress-induced depletion of the intracellular glutamine pool: The potential use of glutamine-containing peptides in parenteral nutrition. Aktuelle-Ernahrungsmedizin 13, 183-189.
22. STEINHARDT, H. J., PALEOS, G. A., BRANDL, M., FEKL, W. L. & ADIBI, S. A. (1984). Efficacy of a synthetic dipeptide mixture as the source of amino acids for total parenteral nutrition in a subhuman primate (baboon): plasma concentration, metabolic clearance, and urinary excretion of a series of dipeptides. Gastroenterology 86, 1562-1569.
23. VASQUEZ, J. A., PALEOS, G. A., STEINHARDT, H. J., LANGER, K., BRANDL, M., FEKL, W. L. & ADIBI, S. A. (1986). Protein nutrition and amino acid metabolism after 4 weeks of total parenteral nutrition with a mixture of 14 dipeptides: serendipitous observations on effects of sepsis in baboons. Am. J. Clin. Nutr. 44, 24-32.
24. WAGHORN, G. C. & BALDWIN, R. L. (1984). Model of metabolite flux within mammary gland of the lactating cow. J. Dairy Sci. 67, 531-544.
25. WEBB, K. E., JR., MATTHEWS, J. C. & DIRIENZO, D.B. (1992). Peptide absorption: a review of current concepts and future perspectives. J. Anim. Sci. 70, 3248-3257.
26. ZIERLER, K. L. (1961). Theory of the use of arteriovenous concentration differences for measuring metabolism in steady and non-steady state. J. Clin. Invest. 40, 2111-2125.